research Interferon in the Treatment of Cutaneous T-Cell Lymphoma
Interferon, especially alfa interferon, is an effective treatment for cutaneous T-cell lymphoma with manageable side effects.
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research Pharmacological Activity and Clinical Use of Polydeoxyribonucleotide
PDRN helps repair tissue and improve wound healing with a high safety profile.
research Gene-Wide Association Study Between the Aromatase Gene (CYP19A1) and Female Pattern Hair Loss
Aromatase gene variation may increase female hair loss risk.
research From Neural Crest Cells to Melanocytes: Cellular Plasticity During Development and Beyond
Melanocyte development from neural crest cells is complex and influenced by many factors, and better understanding could help treat skin disorders.
research 5α-Reductase Type 2 Gene Variant Associations with Prostate Cancer Risk, Circulating Hormone Levels, and Androgenetic Alopecia
A49T gene variant linked to higher prostate cancer risk, lower hormone levels, and slightly reduced balding risk.
research Genome-Wide Meta-Analysis Implicates Mediators of Hair Follicle Development and Morphogenesis in Risk for Severe Acne
Genetic variations affecting skin structure play a key role in severe acne.
research Computational Design and Development of a Novel Voltammetric Sensor for Minoxidil Detection Based on Electropolymerized Molecularly Imprinted Polymer
New sensor detects minoxidil accurately and effectively.
research TCL1 Transgenic Mouse Model as a Tool for the Study of Therapeutic Targets and Microenvironment in Human B-Cell Chronic Lymphocytic Leukemia
The TCL1 transgenic mouse model is useful for understanding human B-cell leukemia and testing new treatments.
research LPA3, A Unique G Protein-Coupled Receptor For Lysophosphatidic Acid
LPA3 is crucial for embryo implantation and links LPA to prostaglandin signaling.
research MicroRNA in Skin Diseases
Certain microRNAs are linked to various skin diseases and could be used to diagnose and treat these conditions.
research Drug Repositioning Using In Silico Compound Profiling
Using computers to analyze drugs can find new uses for them, but actual experiments are needed to confirm these uses.
research Retinoid Metabolism Is Altered in Human and Mouse Cicatricial Alopecia
Altered retinoid metabolism in cicatricial alopecia suggests a balanced vitamin A diet may prevent the condition.
research The Effect of Cilostazol, a Phosphodiesterase 3 (PDE3) Inhibitor, on Human Hair Growth with Dual Promoting Mechanisms
Cilostazol helps hair grow by making hair root cells grow faster and changing growth factor levels.
research Defining the Identity of Mouse Embryonic Dermal Fibroblasts
Researchers identified specific genes that are important for mouse skin cell development and healing.
research Recent Advances in the Chemistry and Pharmacological Activity of New Steroidal Antiandrogens and 5α-Reductase Inhibitors
New compounds show promise for treating hair loss, enlarged prostate, and prostate cancer, with some being more effective and having different side effects than current treatments.
research Structural and Biochemical Changes Underlying a Keratoderma-Like Phenotype in Mice Lacking Suprabasal AP1 Transcription Factor Function
Inhibiting AP1 in mice skin causes structural changes and weakens the skin barrier.
research Vitamin D Activates Type A Natriuretic Peptide Receptor Gene Transcription in Inner Medullary Collecting Duct Cells
Vitamin D boosts a specific gene activity in kidney cells that could improve heart and kidney function.
research Ranitidine And Finasteride Inhibit The Synthesis And Release Of Trimethylamine N-Oxide And Mitigate Its Cardiovascular And Renal Damage Through Modulating Gut Microbiota
Ranitidine and finasteride lower TMAO levels, reducing heart and kidney damage by changing gut bacteria.
research In Vivo Investigation in Pigs of Intestinal Absorption, Hepatobiliary Disposition, and Metabolism of the 5α-Reductase Inhibitor Finasteride and the Effects of Coadministered Ketoconazole
Ketoconazole increases finasteride's effectiveness and lifespan in the body.
research Targeted Expression of SV40 T Antigen in the Hair Follicle of Transgenic Mice Produces an Aberrant Hair Phenotype
SV40 T antigen in hair follicles causes abnormal hair and health issues in mice.
research Genome-Wide Target Enrichment-Aided Chip Design: A 66K SNP Chip for Cashmere Goat
Researchers developed a cost-effective 66 K SNP chip for cashmere goats that is accurate and useful for genetic studies.
research Assessment of Vitamin D Level in Patients with Alopecia Areata
Low vitamin D levels are common in people with Alopecia Areata.
research Synthesis and In Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-Oxo-4-Androstene-17β-Carboxamides as 5α-Reductase Inhibitors and Antiandrogens
The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.
research Androgen Regulation of a Specific Gene in Hamster Flank Organs
Male hormones control a specific gene in hamster skin, with different hormones having varying effects.
research The Clock Gene Brain And Muscle Arnt-Like Protein-1 (BMAL1) Is Involved In Hair Growth
A gene called BMAL1 plays a role in controlling hair growth.
research Genetic Variations Associated With Response to Dutasteride in the Treatment of Male Subjects With Androgenetic Alopecia
Genetic variations affect dutasteride treatment response for male pattern hair loss.
research N6-Methyladenosine Modification of circRNA-ZNF638 Contributes to the Induced Activation of SHF Stem Cells Through miR-361-5p/Wnt5a Axis in Cashmere Goats
A specific RNA modification in cashmere goats helps activate hair growth-related stem cells.
research Global Landscapes of Human Phenotypic Variation in Inherited Traits
Different human traits like skin color and hair type vary between populations due to genetic adaptations to the environment.
research Alopecia Areata: Genetic and Immunological Insights
Understanding the immune-related causes of Alopecia Areata has led to potential treatments like JAK inhibitors.
research Sparse Haplotype-Based Fine-Scale Local Ancestry Inference at Scale Reveals Recent Selection on Immune Responses
Recent selection on immune response genes was identified across seven ethnicities.