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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Researchers identified genes linked to coat color, body size, cashmere production, and high altitude adaptation in goats.

Mutations in certain receptors can cause diseases and offer new treatment options.

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

No clear link between androgen receptor variation and hair loss, but more research needed.

Finasteride helps treat skin issues like acne and baldness by blocking testosterone conversion.

Acne is a common skin condition linked to diet, hormones, and genetics, and early treatment can prevent scarring.

Androgens like testosterone affect skin health and can lead to conditions such as acne and hair loss, with various treatments available.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.

The document concludes that certain genetic mutations and dietary factors are involved in acne development, and treatments like isotretinoin and diet changes can help manage it.

TNF family proteins are crucial for the development of skin features like hair, teeth, and mammary glands.

The document concludes that rapid identification, isolation, and strict infection control are crucial to manage SARS outbreaks.

Topical drugs and near-infrared light therapy show potential for treating alopecia.

Compartmentalized organization might be crucial for stem cells to effectively respond to growth or injury.

The conclusion is that individual differences in COVID-19 severity are influenced by factors like age, sex, race, and genetics, which are important for personalized medicine.

Skin stem cells maintain and repair the outer layer of skin, with some types being essential for healing wounds.

People with PCNT mutations often develop severe insulin resistance and early-onset diabetes during childhood or adolescence.

RACB in barley is crucial for cell polarity and nucleus positioning, aiding fungal infection.

Androgens may block hair growth signals, targeting this could treat hair loss.

Hair proteins have weak spots in their α-helical segments.

Thymic transplantation normalized some T-cells but not others, maintaining immune function.

Mice that can regenerate tissue have cells that pause in the cell cycle, which is important for healing, similar to axolotls.

Mesenchymal stromal cells may help treat severe COVID-19, but more research is needed to confirm their effectiveness.

A certain gene variant may increase the risk of polycystic ovary syndrome in Chinese women.

Rat dermal papilla cells have unique genes crucial for hair growth.

Vitamin D receptor helps control hair growth genes in skin cells.

Melatonin treatment increases a specific RNA in goat cells that boosts cashmere growth.

Skin abnormalities can indicate immunodeficiency due to shared origins with the immune system.