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The we/we wal/wal mice have defects in hair growth and skin layer formation, causing hair loss, useful for understanding alopecia.

Understanding how androgens work is key for creating new treatments for prostate issues and hair/skin conditions.

Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

Activating β-catenin in mammary cells leads to changes that cause early-stage abnormal growths similar to skin structures.

A type of collagen helps hair grow by boosting cell growth and activating a specific hair growth pathway.

Chrousos Syndrome is caused by mutations that make the body less sensitive to glucocorticoids, leading to various symptoms and requiring high-dose treatment.

Androgens like testosterone affect skin health and can lead to conditions such as acne and hair loss, with various treatments available.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

Treatments that reduce oxidative stress and fix mitochondrial problems may help heal chronic wounds.

Wnt signaling controls whether hair follicle stem cells stay inactive or regenerate hair.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Cepharanthine is a well-tolerated drug with multiple medical uses, including anti-inflammatory and anti-cancer properties.

Notch/CSL signaling controls hair follicle differentiation through Wnt5a and FoxN1.

Costunolide may have multiple health benefits, including promoting hair growth and protecting against cancer and diabetes, but more research is needed.

Androgens slow hair growth by altering Wnt signaling in balding cells.

New findings explain how genetic changes, body clocks, and certain molecules affect tissue response to stress hormones.

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

Activating Nrf2 protects human hair follicles from oxidative stress and helps prevent hair growth inhibition.

Valproic acid may help hair grow and could be a safe treatment for hair loss.

Cyclosporine A promotes hair growth and prolongs the active growth phase in human hair follicles, but may work differently than in rodents.

Proper control of β-catenin activity is crucial for development and preventing diseases like cancer.

Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.

Rumex japonicus Houtt. may be an effective treatment for atopic dermatitis by reducing inflammation.

Dosing time affects finasteride's effectiveness and safety in rats.

Androgens reduce BMP2, which weakens the ability of certain cells to help hair stem cells become different types of cells.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Air pollution worsens skin diseases and aging by causing inflammation and oxidative stress.

The secretome from mesenchymal stem cells is a promising treatment that may repair tissue and avoid side effects of stem cell transplantation.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.