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Certain changes to the B-ring of androgen receptor ligands can increase their effectiveness for potential treatments of muscle and bone conditions.

The protein ARA70/ELE1 is involved in male pattern baldness, and lower levels of its short form may lead to hair thinning.

Megestrol acetate helps fat-derived stem cells grow, move, and turn into fat cells through a specific receptor.

We need better ways to test and understand SARMs to make safer and more effective treatments.

Certain genetic variants in the androgen receptor are linked to higher PSA levels, potentially affecting prostate cancer screening outcomes.

Certain gene variations might be linked to severe acne in women but not in men.

A genetic variant in the androgen receptor gene increases heart disease risk in women but not in men.

Melatonin receptors, found in many body parts, can help treat various diseases like depression and diabetes due to their effects on inflammation, tumor progression, sleep disorders, and body mass regulation.

Glucocorticoids and sex hormones affect skin health, with potential for targeted treatments to minimize side effects and treat skin conditions.

A new mutation linked to partial Androgen Insensitivity Syndrome and prostate cancer was found in a patient unhappy with their female gender assignment.

The vitamin D receptor helps maintain hair and bone health even without binding vitamin D.

Vitamin D3 and its receptor are important for hair growth, and understanding receptors could help treat hair graying and skin cancer.

Newer retinoid drugs are effective for skin conditions but have significant side effects.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.

Removing part of the vitamin D receptor stops vitamin D from working properly.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.

PPAR agonists show promise for skin conditions but need more research before being a main treatment.

Reduced AR gene methylation may cause early pubic hair growth in girls.

Most Hairless gene mutations reduce its ability to work with the Vitamin D Receptor, which might explain a certain type of hair loss.

Hairless protein can both repress and activate vitamin D receptor functions, affecting gene regulation.

Four patients with a type of rickets and hair loss had different mutations in their vitamin D receptor gene, causing it to not work properly.

Scientists have developed a new method to detect steroid abuse in athletes using cell-based tests, which could be the future of anti-doping methods.

The androgen receptor is a promising target for breast cancer treatment, especially in triple-negative cases, but more research is needed for personalized therapies.

Selective Androgen Receptor Modulators (SARMs) are drugs that can control the effects of androgens in different tissues, potentially having fewer side effects and promising for treating various conditions.

New treatments for prostate cancer are less toxic and show promise, but more research is needed to enhance their effectiveness and reduce side effects.

Finasteride side effects in young men may be linked to specific gene variations.