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The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.

LEF1 interacts with Vitamin D Receptor, affecting hair follicle regeneration and this could be linked to hair loss conditions.

The androgen receptor is a promising target for breast cancer treatment, especially in triple-negative cases, but more research is needed for personalized therapies.

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

Sex hormones affect brain injury differently in males and females.

The review suggests thorough evaluation and genetic testing for proper diagnosis and treatment of Chrousos syndrome.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

Mice with human gene experienced hair loss when treated with DHT.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

Sebaceous glands play a key role in skin health, immunity, and various skin diseases.

Dihydrotestosterone (DHT) doesn't affect rat skin cell growth, but it does change cell cycle, protein levels, and other cell functions, potentially shortening hair growth cycle.

The research provides a gene-based framework for hair biology, highlighting the Hippo pathway's importance and suggesting links between hair disorders, cancer pathways, and the immune system.

Hairless protein can block vitamin D activation in skin cells.

Human keratinocytes do not naturally respond to androgens.

Finasteride-treated male rats' offspring had altered glucose metabolism, potentially increasing diabetes risk.

Androgen receptors are active in many tissues of both male and female mice, not just reproductive organs.

Wnt signaling is crucial for skin and hair development and its disruption can cause skin tumors.

As skin cells mature, vitamin D receptor levels decrease while retinoid X receptor α levels increase.

The vitamin D receptor can act without its usual activating molecule, affecting hair growth and skin cancer, but its full range of actions is not well understood.

Mutations in the glucocorticoid receptor gene cause reduced sensitivity to glucocorticoids and may lead to poor response to treatment.

Genetic defects in the glucocorticoid receptor gene can cause conditions with abnormal sensitivity to stress hormones, and other factors may also affect this sensitivity.

Mutations in the NR3C1 gene cause a rare condition that affects hormone signaling and can lead to various symptoms, with dexamethasone as a treatment option.

Scopolin and scopoletin from Merremia peltata leaves may help treat hair loss and showed promising results in rabbit tests.

VDR regulation varies by tissue and is crucial for its biological functions.

Bolandiol, a synthetic steroid, builds muscle and bone without greatly affecting sex glands, and works differently from other hormones.

Metabolic Syndrome is linked to several skin conditions, and stem cell therapy might help treat them.

Combination pharmacotherapy is generally more effective for treating keloids and hypertrophic scars.

Mitochondrial Complex I reduces inflammation and increases bone breakdown by affecting certain immune cells.