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Normal skin cell renewal doesn't need RAR signaling, but vitamin A-related skin thickening does.

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

Coffee silverskin may be a beneficial and safe ingredient for cosmetics, offering hydration, firmness, and potential hair growth benefits.

Topical L-thyroxine may help with wound healing and hair growth but should be used short-term due to potential risks.

Different drugs can treat high male hormone levels in women, but they have various effects and some may harm a fetus.

Hair ages and thins due to factors like inflammation and stress, and treatments like antioxidants and hormones might improve hair health.

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.

Surface Plasmon Resonance is a useful tool for studying protein interactions and has potential for future technological advancements.

Thyroid diseases may contribute to autoimmune skin diseases, and more research is needed on their relationship.

Keratin 18 helps diagnose and predict cancer progression and affects cancer growth and spread.

Androgens and androgen receptors are important for metabolic health, affecting how the body uses glucose and fats through mitochondrial function.

VDR regulation varies by tissue and is crucial for its biological functions.

DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.

The nucleus is key in controlling skin growth and repair by coordinating signals, gene regulators, and epigenetic changes.

The conclusion is that the nuclear lamina and LINC complex in skin cells respond to mechanical signals, affecting gene expression and cell differentiation, which is important for skin health and can impact skin diseases.

KLF4 is important for maintaining skin stem cells and helps heal wounds.

The we/we wal/wal mice have defects in hair growth and skin layer formation, causing hair loss, useful for understanding alopecia.

Air pollution (PM10) increases skin inflammation and aging by reducing collagen and may trigger a repair response in skin cells.

Stem cells help remove dead cells to keep tissues healthy by balancing cell replacement and clearance.

Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.

Androgen receptor activity blocks Wnt/β-catenin signaling, affecting hair growth and skin cell balance.

Fat cells are important for tissue repair and stem cell support in various body parts.

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

African American men with prostate cancer have more androgen receptor mutations, which may lead to more aggressive cancer compared to Caucasian American men.

The document concludes that the development of certain tumors is influenced by genetic background and that a specific gene modification can lead to tumor regression and reduced growth.

TLR3 signaling enhances the immunosuppressive properties of human periodontal ligament stem cells.

Phosphorylation controls TFEB's location in the cell, affecting cell metabolism and stress response.

The Wnt signaling pathway is not a major factor in the development of keratoacanthoma, a type of skin tumor.

Chinese domestic goats have unique genetic traits due to domestication and geographic isolation.