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Skin's epithelial stem cells are crucial for repair and maintenance, and understanding them could improve treatments for skin problems.

Lichen planus is a chronic autoimmune disease that is hard to treat and more common in women.

Hair follicle stem cells in hairpoor mice are disrupted, causing hair loss.

Baricitinib reduces inflammation and improves cell health in premature aging cells.

Follistatin and LIN28B together improve the ability of inner ear cells in mice to regenerate into hearing cells.

Synthetic antioxidants are effective, cheap, and stable, with some like zinc and cholecalciferol reducing child and cancer deaths, but the safety of additives like BHA, BHT, TBHQ, and PEG needs more research.

Disrupted stem cell signals in hairpoor mice cause hair loss.

Chick embryo extract helps rat hair follicle stem cells potentially turn into Schwann cells, important for the nervous system.

PDE inhibitors, especially PDE4 inhibitors like apremilast, are effective for certain inflammatory skin conditions but have side effects and can be costly.

NF-κB is crucial for zebrafish heart repair, affecting heart cell growth and repair processes.

Cepharanthine, a Japanese hair loss drug, shows promise as a COVID-19 treatment but needs more testing.

Hormones during pregnancy and lactation keep skin stem cells inactive, preventing hair growth.

Treatments that reduce oxidative stress and fix mitochondrial problems may help heal chronic wounds.

New markers and pathways have been found in skin tumors, helping better understand and diagnose them.

A defective protein in progeria causes cell death and atherosclerosis, but a treatment targeting cell stress may reduce these effects.

The HIF-2α/ARNT complex is important for hair follicle development by controlling cell growth.

5% minoxidil foam effectively regrows hair in women, with postmenopausal women seeing the most improvement.

Vitamin D receptor interacts with certain dietary components to help prevent diseases and regulate hair growth.

RTA 408 cream protects mice from radiation skin damage.

Hair follicle stem cells are promising for wound healing but require more research for safe clinical use.

Wnt activation shows promise for regenerative medicine but requires selective targeting to minimize risks like cancer.

Human prenatal skin develops an immune network early on that helps with skin formation and healing without scarring.

HO-1 helps skin health and healing but can worsen melanoma; it's a potential treatment target for skin diseases.

The E2 protein affects gene activity in hair follicles of mice.

Sex steroids affect the MafB gene differently in male and female hamsters.

The conclusion is that proper signaling is crucial for hair growth and development, and errors can lead to cancer or hair loss.

Blocking COX, especially COX-2, in the skin can reduce inflammation and pain and may help prevent skin cancer.

Melanocyte development from neural crest cells is complex and influenced by many factors, and better understanding could help treat skin disorders.

Immunosuppressive and anti-TNF therapies in IBD patients can increase the risk of skin cancer and cause various skin issues.

The document concludes that mouse models are crucial for studying hair biology and that all mutant mice may have hair growth abnormalities that require detailed analysis to identify.