Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

In this study, Allium hookeri extract increased viability and size of dermal papilla cell spheroids and reduced oxidative stress effects, potentially promoting hair growth by regulating specific protein signaling pathways in human cells.

This study found that sulforaphane treatment enhanced hair regeneration in ob/ob mice by increasing DHT-degrading enzyme levels and lowering plasma testosterone and DHT.

This study found that genetic activation of Nrf2 in keratinocytes accelerates wound repair by enhancing cell proliferation and re-epithelialization, suggesting potential use for Nrf2-activating compounds in individuals with impaired healing.

This study observed that dietary intake of glucoraphanin during juvenile and adolescent stages prevented cognitive deficits and abnormal gene expressions in the brain of adult offspring exposed to maternal immune activation, potentially implicating centrosome-related genes in the development of psychosis.

This review compiled evidence suggesting that flavonoids may promote skin wound healing due to their anti-inflammatory, angiogenesis, re-epithelialization, and antioxidant properties, while also discussing current limitations and future prospects for these compounds as wound-healing agents.

This review discusses various nonfollicular scalp conditions causing secondary scarring or permanent alopecia and highlights the importance of specific diagnoses and treatments but reports no new results.

In laboratory experiments, this study found that the topical prodrug SCD-153, a derivative of 4-methyl itaconate, reduced inflammation-related gene expression and induced significant hair growth in mice, suggesting it as a promising treatment candidate for alopecia areata.

This study found that autophagy plays a role in sebaceous gland function and sebum composition control in mice lacking the Atg7 gene in keratinocytes.

This review discusses various forms of ichthyosis, including genetic and acquired types, detailing their characteristics, causes, and potential management strategies, but reports no new clinical results.

This study suggests that hemoglobin α expression in the epidermis is induced by oxidative stress and may function as an antioxidant, contributing to skin barrier function.

This case report details a 27-year-old woman's diagnosis of systemic lupus erythematosus with immune-mediated intravascular haemolysis, which improved with steroid treatment.

This review discusses the essential roles and complex regulation of PP2A in various physiological processes and reports no clinical results; the authors highlight the need for further mouse model research to explore PP2A's therapeutic potential.

This study found that biallelic mutations in the TTC7A gene affect lymphocyte and gut epithelial cell function, thereby contributing to the development of inflammatory bowel disease in patients.

This study found that exogenous melatonin improved cashmere fiber quality and yield in goats by enhancing antioxidant capacity and reducing pro-aging cytokine expression in secondary hair follicles.

This review examines melatonin's potential effects on human skin and hair follicle pigmentation, highlighting the need to confirm findings from cell cultures in physiological tissue contexts.

This study found that MED1 plays a role in maintaining keratinocyte quiescence and hair follicle stem cell populations, as its absence in mice led to increased keratinocyte proliferation and reduced stem cell numbers.

This review discusses melatonin's potential in dermatology, highlighting its antioxidative, immunomodulatory, and DNA repair properties, but reports no new clinical results.

This review summarizes the potential of N-acetyl-cysteine in managing diseases linked to redox imbalance, discussing its effects from cellular mechanisms to clinical applications, though further research is suggested for broader use.

This study found that Mentha suaveolens aqueous extract activated Nrf-2 and increased detoxifying enzyme expression in keratinocytes, providing protection against oxidative stress without cytotoxicity.

This study found that overexpressing Rps14 in supporting cells promoted hair cell regeneration in the organ of Corti by facilitating cell proliferation and differentiation.

This review summarizes current literature associating mitochondrial dysfunction with dermatologic issues like skin aging, hair loss, and poor wound healing, noting potential benefits in targeting mitochondrial components for treatments.

This study found that a melatonin-loaded microemulsion exhibited controlled release and significant stratum corneum deposition in ex vivo permeation tests, suggesting its potential for further evaluation in treating androgenic alopecia.

In this study, NAC was observed to counteract the negative effects of cyclophosphamide on hair follicles in mice, preserving both biochemical parameters and hair structure, suggesting its potential as a therapeutic option for chemotherapy-induced hair loss.

This study found that topical application of triiodothyronine (T3) can induce the transition of hair follicles from the telogen to the anagen phase in mice and stimulate hair shaft growth in vitro.

This chapter reviews the clinical effects of androgens like testosterone and its metabolites on various body systems and life stages, but reports no new results.

In this study, 1'-S-1'-acetoxychavicol acetate (ACA) from Alpinia galanga showed potential in suppressing testosterone-induced hair loss by inhibiting Nox isozymes in a mouse model of androgenetic alopecia.

This study found that erythrocytes can be generated from human hair follicle mesenchymal stem cells with OCT4 expression, potentially serving as an alternative source for transfusions.

This study found that autophagy is impaired in Birt-Hogg-Dubé syndrome-associated renal tumors and identified that the FLCN protein interacts with key autophagy components regulated by ULK1.

This review summarizes the mechanisms by which Plumbagin, a naphthoquinone derived from plants, may impact inflammation and explores its potential biological effects, highlighting areas that require further comprehensive research before considering it for therapeutic use.

This review discusses the phytochemistry and pharmacological activities of Perilla frutescens, detailing its bioactive compounds and their potential health benefits, but reports no new clinical results.