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The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

The document concludes that treating female hair loss should target reducing excess androgen and blocking its effects on hair follicles, with the best treatments being hormonal therapy, adrenal suppression, and topical minoxidil.

Young women in West Bengal, India, with PCOS often have estrogen resistance, leptin receptor issues, folate deficiency, T2DM, and acanthosis, commonly linked to obesity.

Flutamide, an antiandrogen, has minimal impact on female rat endocrine systems and does not significantly change their reproductive cycles.

Spironolactone is a safe and effective treatment for reducing excessive hair growth in women.

Oestrogens help maintain healthy skin, heal wounds, and may protect against skin aging and cancer.

Vitamin D receptor binds similarly to natural and synthetic ligands, affecting gene regulation.

The study created a test that found hormonal and toxic effects in plant and fungal extracts using prostate cancer cells.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

These drugs cause hair growth without affecting testosterone or adrenal hormones.

Most hirsutism cases are due to PCOS, and treatment focuses on lowering testosterone and blocking its effects.

Plant-based remedies may treat hair loss by reducing inflammation and improving insulin resistance.

Excessive sun protection might cause frontal fibrosing alopecia by disrupting skin immune balance.

Eating alfalfa sprouts every day can raise testosterone levels in middle-aged men, but broccoli sprouts don't have this effect.

Human prostate cells produce more WISP1/CCN4 when there's not enough oxygen.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

BLIMP1 is essential for skin maintenance but not for defining sebaceous gland progenitors.

Sex hormones affect brain injury differently in males and females.

Common Black hair care products may affect hormone levels and potentially impact health, especially in reproductive and metabolic areas.

Certain Chinese herbs, especially Cacumen platycladi, can promote hair regrowth and reduce hair loss-related hormone levels in mice.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

The document concludes that various drugs can manage symptoms and metabolic issues in women with PCOS.

Researchers created five new human scalp cell lines that could be useful for hair growth and loss research.

Parathyroid hormones are important for hair growth, but their use in treating hair loss from chemotherapy is still uncertain.

Hair loss in women can be slowed with treatment, but more research needed for better solutions.

Androgen deprivation therapy doesn't lower the risk of death from COVID-19 in prostate cancer patients.

Blocking the mineralocorticoid receptor can help treat skin thinning caused by steroids.