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This study found that Mentha suaveolens aqueous extract activated Nrf-2 and increased detoxifying enzyme expression in keratinocytes, providing protection against oxidative stress without cytotoxicity.

This study demonstrates that Bazi Bushen capsules may have therapeutic potential against skin photoaging in mice by enhancing NRF2 expression and targeting the KEAP1-NRF2 pathway.

In this study, a 75% ethanol extract of Fructus Psoraleae was found to significantly inhibit 5-α reductase and promote hair growth in mice, indicating its potential as a treatment for androgenetic alopecia through modulation of the Nrf2-Keap1 pathway.

This study found that exosomes derived from human umbilical cord mesenchymal stem cells helped preserve melanocyte function and mitigate stress-induced hair depigmentation in mice by activating the Nrf2-ARE antioxidant pathway under acute neurogenic oxidative stress.

This study found that Kyoh®, a flavonol-rich extract from rocket leaves, may promote hair growth by enhancing the expression of hair growth-related genes in laboratory conditions.

In this study, Nrf-2-expressing hair follicle mesenchymal stem cells showed the most significant therapeutic effect in a rat model of ulcerative colitis, suggesting a new potential treatment for the disease.

This study found that in noise-exposed FVB/NJ mice and cell models, ivacaftor reduced oxidative stress and hearing damage by maintaining CFTR function and increasing Nrf2 expression, suggesting its potential for treating noise-induced hearing loss.

This study found that exogenous melatonin improved cashmere fiber quality and yield in goats by enhancing antioxidant capacity and reducing pro-aging cytokine expression in secondary hair follicles.

This study suggests that altered levels of NRF2 may be important in the development of androgenetic alopecia in men.

Melatonin may protect inner ear cells from damage by reducing cell death and oxidative stress, potentially treating sudden hearing loss.

This study found that kukui nut oil (AMS oil) promotes hair growth in human hair follicle cultures by increasing PGF2α levels and activating Nrf2 signaling, and a human trial confirmed its efficacy in enhancing eyelash growth.

This study found that Nrf2 activation protected keratinocytes from UVB damage but also caused thickening, inflammation, and cysts, limiting its therapeutic potential for skin protection.

In this pilot study, minoxidil-treated scalp skin grafts from hair loss patients on mice showed increased expression of key anti-aging biomarkers and hair regrowth, suggesting minoxidil as a potential anti-aging agent by boosting VEGF-A production in hair follicles.

This study found that prolonged Nrf2 activation in mouse keratinocytes led to enlarged sebaceous glands, hair loss, and cysts, suggesting a role for Nrf2 in conditions like MADISH.

This study found that estradiol significantly reduces cisplatin-induced cochlear hair cell death in mice, likely by activating Nrf2 and phase II detoxification enzymes.

This study found that exosomes from human umbilical cord mesenchymal stem cells reduced oxidative stress and inflammation in UVB-induced skin injury in cell and mouse models, suggesting their potential for treating UV-damaged skin by influencing Nrf2 and NF-κB pathways.

In this study, preconditioning hair follicle-derived stem cells with valproic acid and/or rapamycin was shown to protect against damage caused by oxygen glucose and serum deprivation, potentially enhancing stem cell therapy efficacy for ischemic stroke by improving cell adaptation to oxidative stress.

This study provides evidence that Fernblock® upregulates antioxidant pathways in cultured keratinocytes, potentially protecting against damage from fine pollutant particles.

In this study, yellow Chinese chive extract was observed to protect against acetaminophen-induced liver toxicity in mice by enhancing antioxidant pathways and reducing liver injury markers.

This study found that ferulic acid promotes wound healing by inhibiting β-catenin in keratinocytes and activating Nrf2 to reduce inflammation at the wound edge.

This study demonstrated that Forsythiaside A improved survival and reduced neurological deficits in rats with cerebral ischemic injury, potentially through activating Nrf2 and reducing ER stress pathways.

This study found that cepharanthine can inhibit gastric cancer cell activity by inducing oxidative stress and altering energy metabolism, suggesting its potential for gastric cancer treatment.

This study found that cephalanthine inhibited the growth of gastric cancer cells in vitro and in vivo by inducing oxidative stress and altering energy metabolism, suggesting its potential as a treatment for gastric cancer.

This study found that cepharanthine significantly inhibits EqHV-8 infection in vitro and improves lung tissue pathology in infected mice by reducing oxidative stress through specific signaling pathways, suggesting its potential as a treatment for equid herpesvirus type 8.

This study found that altered Nrf2 levels may play a significant role in the development of androgenetic alopecia in men.

This study reported that fermented yeast complex extract may promote hair regrowth by modulating antioxidative and anti-inflammatory pathways in dermal papilla cells and increasing hair follicle numbers in an animal model.

This study found that sinapic acid demonstrated antioxidant and anti-inflammatory effects against UVB-induced damage in human keratinocytes, suggesting its potential as an anti-aging cosmetic ingredient.

This study found that essential oils boost hair growth activity in dermal papilla cells by scavenging reactive oxygen species and upregulating growth factor biomarkers.

This study found that the ashwagandha extracts ASH-Ext1 and ASH-Ext2 show different pharmacological activities in cell models due to their distinct withanolide proportions, highlighting the need for standardized extraction protocols to ensure consistent therapeutic efficacy.

This study found that activating the Nrf2 pathway in human mast cells effectively suppresses degranulation and inflammation induced by substance P.