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This study reports that miR-302 promotes pluripotency by inhibiting NR2F2 and indirectly regulating OCT4 in stem cells, enhancing reprogramming efficiency when added to traditional factors.

This study found that prolonged Nrf2 activation in mouse keratinocytes led to enlarged sebaceous glands, hair loss, and cysts, suggesting a role for Nrf2 in conditions like MADISH.

This study found that activating Nrf2 in human hair follicles significantly reduced oxidative stress, lipid peroxidation, and protected against hair growth inhibition, suggesting a protective role for Nrf2 against redox insult in this context.

This review discusses the potential benefits of activating NRF2 for treating hair follicle disorders linked to oxidative stress and reports no new clinical results.

This study provides evidence that Fernblock® upregulates antioxidant pathways in cultured keratinocytes, potentially protecting against damage from fine pollutant particles.

This review discusses the role of Nrf2 in hearing loss and its potential as a target for developing hearing protection drugs, but reports no new clinical results.

This study found that ferulic acid promotes wound healing by inhibiting β-catenin in keratinocytes and activating Nrf2 to reduce inflammation at the wound edge.

This study found that genetic activation of Nrf2 in keratinocytes accelerates wound repair by enhancing cell proliferation and re-epithelialization, suggesting potential use for Nrf2-activating compounds in individuals with impaired healing.

This study found that TAp63 and ΔNp63 isoforms in the p63 family interact with different transcription factors to regulate distinct transcriptional programs, affecting various biological functions like metabolic pathways, oxidative stress response, and epithelial morphogenesis in mouse epidermal cells.

This study demonstrated that Forsythiaside A protected against oxidative stress in both cell models and a mouse model of liver damage, suggesting its potential as a liver-protective agent.

Melatonin may protect inner ear cells from damage by reducing cell death and oxidative stress, potentially treating sudden hearing loss.

This study found that α-ketoglutarate protected dermal papilla cells from oxidative stress by enhancing the Nrf2 pathway and mitigating cell damage through the ERK/Nrf2 axis.

This study found that in noise-exposed FVB/NJ mice and cell models, ivacaftor reduced oxidative stress and hearing damage by maintaining CFTR function and increasing Nrf2 expression, suggesting its potential for treating noise-induced hearing loss.

In this study on a mouse model of vitiligo, NB-UVB/ADSC combination therapy improved oxidative stress and calcium homeostasis, but the protective effect was reversed by inhibiting Nr2 signaling.

In this study, Nrf-2-expressing hair follicle mesenchymal stem cells showed the most significant therapeutic effect in a rat model of ulcerative colitis, suggesting a new potential treatment for the disease.

This study found that estradiol significantly reduces cisplatin-induced cochlear hair cell death in mice, likely by activating Nrf2 and phase II detoxification enzymes.

In this study, yellow Chinese chive extract was observed to protect against acetaminophen-induced liver toxicity in mice by enhancing antioxidant pathways and reducing liver injury markers.

In this study, researchers found that 4-Octyl itaconate (4-OI) inhibited cisplatin-induced ferroptosis and protected auditory cells by activating the NRF2/HO-1 signaling pathway, suggesting a potential therapeutic approach for reducing hearing loss associated with cisplatin treatment.

This study found that kukui nut oil (AMS oil) promotes hair growth in human hair follicle cultures by increasing PGF2α levels and activating Nrf2 signaling, and a human trial confirmed its efficacy in enhancing eyelash growth.

This study found that exosomes derived from human umbilical cord mesenchymal stem cells helped preserve melanocyte function and mitigate stress-induced hair depigmentation in mice by activating the Nrf2-ARE antioxidant pathway under acute neurogenic oxidative stress.

This study demonstrates that Bazi Bushen capsules may have therapeutic potential against skin photoaging in mice by enhancing NRF2 expression and targeting the KEAP1-NRF2 pathway.

This study found that exosomes from human umbilical cord mesenchymal stem cells reduced oxidative stress and inflammation in UVB-induced skin injury in cell and mouse models, suggesting their potential for treating UV-damaged skin by influencing Nrf2 and NF-κB pathways.

In this study, a 75% ethanol extract of Fructus Psoraleae was found to significantly inhibit 5-α reductase and promote hair growth in mice, indicating its potential as a treatment for androgenetic alopecia through modulation of the Nrf2-Keap1 pathway.

In this study, preconditioning hair follicle-derived stem cells with valproic acid and/or rapamycin was shown to protect against damage caused by oxygen glucose and serum deprivation, potentially enhancing stem cell therapy efficacy for ischemic stroke by improving cell adaptation to oxidative stress.

This case report highlights a novel NR5A1 gene variant associated with a severe 46,XY disorder of sex development, stressing the importance of genetic screening in similar cases.

This study suggests that impaired Nrf2 signaling and its relationship with keratin 16 may contribute to follicular hyperkeratinization and occlusion in hidradenitis suppurativa, opening new therapeutic avenues.

This study found that a 532 nm laser at 15 J/cm² enhanced the proliferation and differentiation of tendon-derived stem cells in rats, potentially accelerating tendon healing through the up-regulation of Nr4a1.

In laboratory models of human skin, this study found that treating with resveratrol significantly increased glutathione levels, potentially enhancing the skin's antioxidant defenses.

This study found that Mentha suaveolens aqueous extract activated Nrf-2 and increased detoxifying enzyme expression in keratinocytes, providing protection against oxidative stress without cytotoxicity.