research Drug Therapy in Polycystic Ovarian Syndrome
This study found that a combination of low-dose flutamide and metformin therapy may reverse insulin resistance and reduce fat mass in nonobese adolescents with PCOS.
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research Androgenetic alopecia: Quality-of-life and associated lifestyle patterns
This study concluded that heredity is associated with hair loss, while lifestyle and stress factors are not significantly related.
research The effect of dietary modulation of sulfur amino acids on cystathionine β synthase–deficient mice
This review discusses dietary manipulation strategies in a mouse model of CBS deficiency and reports no new results; the authors emphasize the importance of understanding gene-diet interactions.
research Minoxidil e óleo essencial de alecrim: proposta de solução tópica para alopecia androgenética
This study developed and evaluated topical formulations containing 5% minoxidil and 1% rosemary essential oil for androgenetic alopecia treatment, finding them physically and chemically suitable, but noted that further stability tests and clinical trials are needed to confirm therapeutic efficacy and safety.
research Killing Two Birds with One Stone: Oral Tofacitinib Reverses Alopecia Universalis in a Patient with Plaque Psoriasis
This case report describes complete hair regrowth in a patient with alopecia universalis and improved psoriasis after treatment with the oral Janus kinase inhibitor, tofacitinib.
research Oxidative Stress–Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia
This study suggests that oxidative stress may contribute to androgenetic alopecia by inducing premature senescence and secretion of hair growth inhibitors in dermal papilla cells from balding scalp.
research The Peripheral Clock Regulates Human Pigmentation
This study found that silencing clock genes BMAL1 or PER1 in human hair follicles increased melanin content and melanocyte activity, suggesting these genes influence pigmentation.
research Dissociated Human Dermal Papilla Cells Induce Hair Follicle Neogenesis in Grafted Dermal–Epidermal Composites
This study demonstrated that cultured human dermal papilla cells can induce full hair follicle formation when combined with neonatal foreskin keratinocytes in a grafted dermal-epidermal construct on mice.
research Neuroactive gonadal drugs for neuroprotection in male and female models of Parkinson's disease
In this study, several compounds, including estrogen and Dutasteride, showed neuroprotective effects on dopaminergic neurons in an MPTP mouse model of Parkinson's disease.
research Fate of Prominin-1 Expressing Dermal Papilla Cells during Homeostasis, Wound Healing and Wnt Activation
In this study using a mouse model, Prom1+ dermal papilla cells were found to regulate the size of the papilla via β-catenin communication but did not aid in dermal repair.
research Lack of Collagen VI Promotes Wound-Induced Hair Growth
This study found that collagen VI influences hair follicle growth and wound-induced regrowth by activating the Wnt/β-catenin signaling pathway in mice, suggesting potential therapeutic targets for hair loss.
research Disrupted Ectodermal Organ Morphogenesis in Mice with a Conditional Histone Deacetylase 1, 2 Deletion in the Epidermis
This study found that reducing HDAC1 activity in the skin of mice led to defects in hair follicle structure and pigmentation, highlighting HDAC's role in skin and hair maintenance.
research Re-Evaluating Cyclosporine A as a Hair Growth–Promoting Agent in Human Scalp Hair Follicles
This study provides evidence that Cyclosporine A inhibits catagen development in human hair follicles, suggesting different underlying mechanisms from those observed in rodent studies.
research Signalling by senescent melanocytes hyperactivates hair growth
In this study using genetic mouse models, researchers discovered that senescent melanocytes in nevi secrete osteopontin, which activates hair stem cells, enhancing hair growth; this process is mirrored in human hairy nevi, suggesting a potential therapeutic target for regenerative disorders.
research 5α-Reductase type 1 inhibition of Oryza sativa bran extract prepared by supercritical carbon dioxide fluid
In this study, fraction No. 3 of Oryza sativa bran extract demonstrated high unsaturated fatty acid content and significant 5α-reductase inhibition, suggesting potential for developing anti-androgenic alopecia products.
research Transfollicular enhancement of gel containing cationic niosomes loaded with unsaturated fatty acids in rice (Oryza sativa) bran semi-purified fraction
This study suggests that gel containing OSF3 loaded in niosomes offers high transfollicular penetration for topical anti-androgenic alopecia treatment with minimal systemic effect.
research Expanding the Clinical and Mutational Spectrum of Recessive AEBP1-Related Classical-Like Ehlers-Danlos Syndrome
This study identifies a likely pathogenic homozygous missense variant in the AEBP1 gene in a patient with symptoms of classical Ehlers-Danlos syndrome, suggesting new perspectives for EDS classification and research.
research Mrp4, A New Mitogen-Regulated Protein/Proliferin Gene; Unique in this Gene Family for its Expression in the Adult Mouse Tail and Ear1
This study identified a new gene, mrp4, in mice, which suggests it may have a unique role in the growth and development of hair follicles in the ears and tails.
research Physico-Chemical Properties of Cationic Niosomes Loaded with Fraction of Rice (Oryza sativa) Bran Extract
In this study, loading niosomes with Oryza sativa bran extract altered their physical properties, suggesting potential for developing formulations aimed at anti-hair loss products.
research Rethinking regeneration: empowerment of stem cells by inflammation
This study found that immune cells, including T cells and macrophages, significantly influence stem cell behavior and tissue regeneration by secreting cytokines and inflammatory factors in mice.
research In vitro–in vivo assessments of apocynin-hybrid nanoparticle-based gel as an effective nanophytomedicine for treatment of rheumatoid arthritis
In this study, researchers developed and tested a gel containing apocynin-loaded nanoparticles that showed promising results in treating rheumatoid arthritis in rats, suggesting potential for novel topical treatments in inflammatory conditions.
research Systems Approach to Human Hair Fibers: Interdependence Between Physical, Mechanical, Biochemical and Geometric Properties of Natural Healthy Hair
This review explores the complex interrelationships among different properties of natural hair fibers and underscores the need for a holistic taxonomy to improve data interpretation across disciplines, but it reports no new experimental results.
research The oestrogen receptor 2 (ESR2) gene in female-pattern hair loss: replication of association with rs10137185 in German patients
This study reports an association between the ESR2 gene variant rs10137185 and female-pattern hair loss in German patients.
research Tendency to underestimate the severity of androgenetic alopecia
People often underestimate hair loss severity, with fewer seeking treatment, and it's more distressing for women.
research Silver nanoparticles in medicine and technology: Synthesis, functionality and future prospects
This review highlighted the potential of silver nanoparticles' antibacterial properties across biomedical, pharmaceutical, and dental applications, and emphasized plant-based biosynthesis methods as eco-friendly alternatives to conventional nanoparticle production despite existing toxicity concerns.
research Surgery of Kerion, a Nightmare for Nondermatologists
This case report described a misdiagnosed kerion in a 10-year-old child initially treated as a bacterial abscess, leading to unnecessary surgery and residual scarring alopecia.
research Edible oil-producing plants in the Sinja Valley, Jumla, Nepal
This study found that Sinja Valley residents possess traditional knowledge of 13 edible oil-producing plant species, yet this knowledge is at risk due to sociocultural changes. Despite its benefits, including treating disorders like gastritis, use of indigenous oils is declining as commercial products become prevalent.
research Infliximab-Associated Psoriasiform Alopecia
This study reported two cases where infliximab-associated psoriasiform alopecia resolved with significant hair regrowth after stopping infliximab and using potent topical steroid treatment.
research Synthesis of Cu 4 O 3 nanoparticles using pumpkin seed extract: Optimization, antimicrobial, and cytotoxicity studies
This study reported a green synthesis method for copper oxide nanoparticles using pumpkin seed extract, achieving significant antibacterial activity against Bacillus subtilis and moderate cytotoxic effects against certain cancer cell lines, indicating potential biomedical applications for these eco-friendly nanomaterials.
research Aplicação da nanotecnologia no tratamento da alopecia
This review critically analyzes recent literature on the use of nanotechnology in alopecia treatment, reporting promising results for improving drug delivery and hair growth, though challenges in maintaining physical stability may limit large-scale commercialization.