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This study developed and validated a sensitive LC-MS/MS method for quantifying tamsulosin in human serum, achieving high analyte recovery and demonstrating applicability in clinical research for benign prostatic hyperplasia.

This study demonstrated that an LC/MS-MS method could effectively detect and quantify the vitamin B3 vitamer nicotinamide in human hair, suggesting its potential use for long-term deficiency examination.

This study successfully established and validated a method using LC-MS/MS to measure multiple androgens in plasma, finding that individuals with acne had higher levels of certain androgens compared to those with obesity.

This study developed a method to measure local steroid hormone concentrations in hair, providing new insights into hormone dynamics associated with androgenetic alopecia.

The document concludes that using LC-MS/MS for measuring androgens is more accurate than older methods, but it needs careful validation and standardized references to be most effective.

This paper reviews the diagnostic criteria, etiological factors, and treatment approaches for PCOS, highlighting the importance of considering metabolic issues such as insulin resistance and obesity, but reports no new findings.

This review discusses recent advancements in understanding and managing congenital adrenal hyperplasia, including improvements in screening, diagnostics, and potential genetic and cell-based treatments, but reports no new clinical findings.

This review examines the epidemiology, pathophysiology, diagnosis, and management strategies for non-classic congenital hyperplasia due to 21-hydroxylase deficiency, and provides evidence-based recommendations for its treatment and genetic counseling.

This study developed a novel method to simultaneously measure finasteride, dutasteride, and related biomarkers in serum, finding that both drugs lowered DHT levels while increasing substrate concentrations.

This study found that LC-MS/MS is a more reliable method than immunoassays for measuring serum 17OHP and androgen levels in women with hyperandrogenism.

This study suggests that analyzing hair samples with a liquid chromatography-mass spectrometric assay may offer a reliable method to measure average quarterly vitamin D levels, potentially complementing blood tests.

This study developed and validated a label-free assay using LC-MS to screen for S5αR inhibitors, identifying Thai herbal extracts, Impatiens balsamina L. and Curcuma longa L., as promising sources.

This study developed and validated a mass spectrometric method to measure hydroxy-androgens in serum, which aids in understanding androgen synthesis in castration resistant prostate cancer.

A new method was developed to accurately measure enzyme activity related to prostate health.

In this study, researchers found that subjects with clinical alopecia had significantly higher levels of squalene in their hair bulbs compared to controls, suggesting squalene as a potential metabolic and pathogenic marker for certain alopecia conditions.

This study found that co-administration of ketoconazole significantly altered the pharmacokinetics of dutasteride in rats, suggesting an interaction potential between dutasteride and azole antifungal drugs.

This study found that LC-MS/MS assays provided more reliable and precise steroid measurements in human serum compared to traditional immunoassays, particularly at lower concentrations.

This study found that hair samples from chronic tramadol and cannabis users showed positive drug presence for 3-4 months and 6-7 months, respectively, after discontinuation.

This study found that finasteride treatment for androgenic alopecia significantly increased certain plasma polyamine levels over three years, but did not alter polyamine levels in urine.

This study found that benzodiazepine therapy in women with idiopathic hirsutism significantly increased sex hormone binding globulin and decreased dehydroepiandrosterone sulphate, but did not significantly affect hair growth.

This study found that cutaneous pyridoxal 5'-phosphate hydrolase activity may be carried out by an enzyme different from the classical tissue-nonspecific alkaline phosphatase in human and mouse skin.

This study found that diagnosing non-classical 3 beta-hydroxysteroid dehydrogenase deficiency solely based on elevated serum or urinary 5-ene-steroids may not be reliable.

This study suggests that increased putrescine levels may disrupt normal hair follicle development in transgenic mice, leading to hair loss and altered skin structure, yet these mice appear more resistant to skin tumorigenesis.

This study found that elevated serum cortisol levels and other immunological changes are significantly involved in the active phases of psoriasis eruptions.

This study found that a topical hedgehog agonist can stimulate hair growth by promoting the transition from the resting to growth phase of the hair cycle in adult mouse skin.

This study suggests that G. sibiricum has potent aldose reductase inhibitory activity, primarily due to kaempferol rhamnosides, and may be further explored as a natural treatment for diabetes-related complications.

This study determined the broad class and molecular species of glycerophospholipids in Eastern red bat sebum, highlighting differences from previous bat lung surfactant studies.

This study found that measuring specific steroid hormone levels can aid in diagnosing P450 oxidoreductase deficiency, a subtype of congenital adrenal hyperplasia, by distinguishing affected patients from healthy individuals.

In this study, researchers identified two potential urinary biomarkers, testosterone–glucuronide and 11α-hydroxyprogesterone, along with four candidate biomarkers, to help understand and diagnose polycystic ovary syndrome.

This study found that valproic acid may interfere with the leucine metabolic pathway by inhibiting 3-methylcrotonyl-CoA carboxylase and biotinidase, which could contribute to side effects like skin rash and hair loss in patients.