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The document concludes that sex hormones are crucial for mammalian reproduction, health, and behavior, and require more research for therapeutic use.

Proxalutamide improved blood markers related to inflammation, immune response, and clotting in COVID-19 patients, potentially reducing hospitalizations.

Menstrual disorders are common in adolescents and can be influenced by weight, activity, and health issues, requiring careful evaluation and more research for effective treatment.

The document concludes that early and personalized treatment for PCOS in adolescents is crucial to manage symptoms and prevent long-term health issues.

Inhibitors of the enzyme 5 alpha-reductase could potentially treat disorders like prostate cancer and baldness.

Low-dose flutamide helps reduce excessive hair growth and is even more effective with birth control, without bad effects on blood fats.

Flutamide combined with an LHRH agonist effectively inhibits prostate growth, suggesting it could treat prostate cancer.

Liposomes can make the antiandrogen RU 58841 more effective for skin application by reducing absorption, increasing skin retention, and targeting sebaceous structures.

New pregnane derivatives were more effective than finasteride at inhibiting a key enzyme for male pattern baldness.

Hirsutism is too much hair growth in women like the pattern in men, often caused by high male hormones, and can be treated with hormone control and hair removal methods.

Androgenetic alopecia involves genetics, hormones, and can be treated with medications or surgery.

Using finasteride or dutasteride may cause long-lasting erectile dysfunction.

Endocrine therapies for cancer significantly increase the risk of hair loss.

Thujae occidentalis semen extract may help treat male pattern baldness by blocking a hair loss-related enzyme and reducing hair loss in mice.

Multimodal minoxidil microemulsion is more effective in treating hair loss than minoxidil alone.

Most treatments for hair loss in 1997 were not effective for most people, and maintaining hair growth was difficult.

Flutamide works better than finasteride for hirsutism, and combining both is slightly better but not much.

Menopausal acne is treated with medications and lifestyle changes, but careful choice is needed due to side effects.

Low-dose anti-androgen drugs and certain drug combinations are effective for hirsutism, and insulin sensitizers show promise, especially for those with polycystic ovarian syndrome.

The document concludes that managing PCOS involves treating symptoms and reducing long-term metabolic risks, with lifestyle changes being important.

Finding new uses for existing drugs is promising and can lead to safer, more effective medicines.

Anti-androgens are safe and effective for treating moderate to severe adult female acne.

The right dosage of CPA and TB can work as a safe and reversible male contraceptive in monkeys.

Low-dose flutamide improved hirsutism and satisfaction in women but had common side effects, causing some to stop treatment.

Possible link between COVID-19 and hair loss; more research needed.

PCOS is a complex condition with major health impacts, needing more research for better diagnosis and treatment.

The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

Experts recommend using evidence-based methods to diagnose and treat hirsutism, focusing on symptoms and underlying causes.

The bulletin provides guidelines for diagnosing and managing PCOS, suggesting weight loss, hormonal contraceptives, and diabetes screening, with clomiphene for infertility and various treatments for excess hair.

Blocking the enzyme 5α-reductase can shrink the prostate and help treat enlarged prostate issues.