4 citations
,
October 2008 in “International Journal of Dermatology” This case report highlights a rare presentation of hair-thread tourniquet syndrome in a two-year-old child, emphasizing that prompt identification and removal of the constricting fiber is crucial for successful treatment and prevention of tissue damage.
90 citations
,
October 2023 in “Advanced Drug Delivery Reviews” This review highlights that unresolved inflammation is a major issue in diabetic foot ulcers and discusses emerging biomaterials-based strategies to modulate the inflammatory response, potentially aiding in tissue regeneration and healing in these chronic wounds.
11 citations
,
January 2019 in “Dermatologic Surgery” In this study, hair follicle transplantation into nonhealing ulcers promoted rapid wound closure, with differing scar quality and hair growth between the central and peripheral wound areas.
3 citations
,
January 2020 in “Journal of Cutaneous and Aesthetic Surgery” This review highlighted that despite existing treatments, chronic nonhealing leg ulcers remain a significant therapeutic challenge, necessitating the development of new methods that are effective, safe, and affordable for patients.
April 2026 in “Frontiers in Bioengineering and Biotechnology” This study found that a cellulose membrane significantly shortened the healing time and reduced the ulcer area in patients with chronic venous leg ulcers compared to a standard antimicrobial dressing.
September 2017 in “Journal of Investigative Dermatology Symposium Proceedings” This report highlights four cases where squamous cell carcinoma was misdiagnosed in individuals with darker skin, emphasizing the challenges in accurate diagnosis for this population.
112 citations
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October 2008 in “Wound Repair and Regeneration” This study demonstrated that disrupting sonic hedgehog signaling, using cyclopamine, significantly impaired wound healing in a mouse model, suggesting its crucial role in postnatal tissue repair.
3 citations
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January 2012 in “Journal of cosmetics, dermatological sciences and applications” This descriptive study reported that cutaneous issues, particularly anesthesia and neuropathy dermatitis, were common at saphenous vein harvesting sites in Iraqi patients who underwent coronary artery bypass surgery.
June 2026 in “Frontiers in Pharmacology” This review highlights the potential of stem cell-derived secretome as a promising cell-free approach for wound healing, offering advantages over live cell therapies in terms of safety, scalability, and storage.
November 2024 in “Journal of Investigative Dermatology” This study identified PTEN as a key regulator in non-healing venous leg ulcers, suppressing immune responses and lymphangiogenesis, suggesting its potential as a therapeutic target for promoting VLU healing.
25 citations
,
January 2018 in “Acta Clinica Croatica” This study found that allogeneic platelet gel significantly improved healing in non-healing chronic lower leg ulcers compared to hydrogel treatment.
2 citations
,
November 2018 in “Cell Stem Cell” This study reported that wound-resident mesenchymal cells can be reprogrammed to generate epithelial tissues, aiding in the closure of large, non-healing ulcers without signs of malignant transformation.
May 2026 in “Indian Dermatology Online Journal” In this case report, a 66-year-old woman with rheumatoid arthritis developed cutaneous ulceration attributed to leflunomide treatment, which significantly healed after discontinuing the drug and administering cholestyramine, underscoring the need for careful monitoring of leflunomide's adverse effects.
February 2009 in “Journal of The American Academy of Dermatology” A man with Klinefelter syndrome had a leg ulcer that didn't heal well, even with treatment.
January 2023 in “Odisha Journal of Psychiatry” This case study describes a patient initially misdiagnosed with pediculosis capitis, later identified as having trichotillomania, highlighting the importance of thorough behavioral inquiries by physicians in such cases.
15 citations
,
January 2016 in “Journal of cell science & therapy” This study found that autologous micro-grafts improved wound healing and reduced pain in leg ulcers unresponsive to routine treatments within one week, lasting up to a month.
63 citations
,
October 2012 in “Wound Repair and Regeneration” This study found that transplanting autologous scalp follicular grafts into chronic leg ulcers led to a greater reduction in ulcer size compared to non-grafted areas, suggesting a promising therapeutic alternative.
July 2026 in “Frontiers in Immunology” This research proposes a comprehensive "four-dimensional technology toolbox" for reprogramming wound-repair cells, aiming to treat chronic non-healing wounds like diabetic foot ulcers by altering fibroblasts, keratinocytes, and macrophages to regenerative phenotypes, and addressing clinical translation challenges.
March 2024 in “International Journal of Rheumatic Diseases” This case report describes successful wound healing in a patient with chronic gout and tophaceous ulcers following platelet-rich plasma therapy, highlighting its potential effectiveness in treating non-healing wounds.
7 citations
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November 2020 in “Journal of Tissue Viability” In this study, follicular unit extraction grafting using a patient's own scalp follicles showed promise in healing chronic ulcers in a woman with recessive dystrophic epidermolysis bullosa.
This study found that human placental extract significantly improved melasma, chronic ulcers, and alopecia areata without major adverse effects, suggesting its effectiveness and safety for these conditions.
In this study, autologous platelet-rich plasma treatment improved androgenic alopecia outcomes in men and women and significantly reduced the area and volume of chronic ulcers.
8 citations
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September 2016 in “The American Journal of Dermatopathology” This study found that eccrine duct dilation is significantly more frequent in cicatricial alopecias compared to noncicatricial alopecias, possibly due to the scarring process.
2 citations
,
January 2018 in “Recent clinical techniques, results, and research in wounds” This review discusses the effects of low-level laser therapy in various biological processes for wound healing and tissue repair and reports no new results.
6 citations
,
October 2020 in “Endocrine journal” This case report identifies two specific mutations in the WRN gene in a 40-year-old female with Werner syndrome, highlighting the need for awareness of its early manifestations and treatment options.
4 citations
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May 2020 in “Cureus” This case report describes an adult male from India with Werner's syndrome due to a novel homozygous mutation in the WRN gene, characterized by several premature aging symptoms.
September 1998 in “Journal of The European Academy of Dermatology and Venereology” Phototrichogram helps assess hair loss severity.
April 2015 in “Reactions Weekly” Some elderly men had healing problems after using imiquimod and diclofenac for skin conditions on their scalps.
12 citations
,
March 2018 in “Bioengineering” This review discusses the use of non-transfusional hemocomponents in surgical procedures for tissue regeneration and reports no new empirical findings.
56 citations
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March 2016 in “International Wound Journal” This review concludes that autologous split-thickness skin grafting remains the gold standard for safety and efficacy in treating chronic leg ulcers, with greater success in venous ulcers.