3 citations
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February 2023 in “International Journal of Molecular Sciences” This review discusses the composition, preparation, and applications of autologous platelet and extracellular vesicle-rich plasma, highlighting its potential benefits and the need for further research, but it reports no new clinical findings.
March 2024 in “Agriculture” The researchers reviewed the status, challenges, and future prospects of CRISPR/Cas9-mediated gene-editing technology in livestock breeding, noting its benefits and highlighting concerns about low efficiency in inserting foreign genes and off-target effects.
35 citations
,
May 2019 in “Frontiers in genetics” This study reported that specific non-coding RNAs may regulate the hair follicle cycle in Angora rabbits by acting as competitive endogenous RNAs, enhancing understanding of ncRNA roles in hair growth.
22 citations
,
April 2017 in “Journal of Investigative Dermatology” This review highlights recent advances in understanding how non-coding RNAs, particularly miRNAs and lncRNAs, regulate skin development and homeostasis, but reports no new clinical results.
16 citations
,
November 2022 in “eLife” This study found that specific genetic changes in both coding and noncoding regions may have independently driven the evolution of hairlessness in various mammalian species through accelerated evolution.
11 citations
,
October 2021 in “Frontiers in Cell and Developmental Biology” This review summarizes the role of non-coding RNAs in hair follicle regeneration and highlights potential therapeutic strategies, though it reports no new experimental results.
7 citations
,
October 2023 in “BMC Genomics” In this study, researchers used transcriptome sequencing to identify various noncoding RNAs in the skin tissues of Jiangnan cashmere goats and found that certain long noncoding RNAs may play a role in regulating cashmere fiber fineness, offering new insights for breeding programs.
3 citations
,
September 2023 in “Skin research and technology” This review article highlights the potential of mesenchymal stem cells, their exosomes, and non-coding RNAs in repairing aging skin tissues due to their ability to secrete beneficial compounds, suggesting their promising role in photoaging treatment without causing immune rejection or granuloma formation.
2 citations
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March 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, researchers used an evolutionary-rate-based method to identify genetic elements associated with reduced hair in mammals, finding a dichotomy between accelerated coding sequences and noncoding regulatory elements influencing hair growth.
This research identified genetic sequences that evolved at different rates in hairless versus hairy mammals, suggesting specific genetic changes contributed to the convergent evolution of hairlessness across various mammalian species.
This study identified genetic regions evolving at different rates in hairless mammals, suggesting that specific genomic changes may contribute to the evolution of hairlessness across various species.
117 citations
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May 2017 in “Human Reproduction Update” This review examines the epidemiology, pathophysiology, diagnosis, and management strategies for non-classic congenital hyperplasia due to 21-hydroxylase deficiency, and provides evidence-based recommendations for its treatment and genetic counseling.
23 citations
,
January 2022 in “Biomaterials Science” Non-viral vectors show promise for safe and effective CRISPR/Cas9 gene editing in treating diseases.
April 2024 in “Journal of pharmacy & pharmacognosy research” This study used in silico analysis to identify 4-[2-(4-nitrophenyl)ethylcarbamoyl]benzenesulfonyl as a potential inhibitor of the EGFR mutant associated with NSCLC, highlighting the need for further in vitro and in vivo validation.
247 citations
,
June 2021 in “Frontiers in Cell and Developmental Biology” This review discusses the role of lncRNA Xist in cell growth regulation and disease development, particularly cancer, and reports no new experimental results.
129 citations
,
October 2017 in “BMC Genomics” This study identified potential ceRNA regulatory networks in cashmere goat hair follicle cycling, expanding understanding of lncRNA and miRNA biology and annotation of the goat genome.
61 citations
,
June 2019 in “BMC Genomics” This study explored the expression and potential functions of long non-coding RNAs in the skin pigmentation of Koi carp, revealing their involvement in pigmentation and differentiation mechanisms.
37 citations
,
May 2018 in “Frontiers in physiology” This study identified key long non-coding RNAs and mRNAs involved in primary wool follicle induction in carpet wool sheep, emphasizing their roles in hair follicle development and skin processes.
32 citations
,
May 2018 in “Cell Cycle” This study found that melatonin exposure promoted hair follicle fiber growth in Cashmere goat cultures, potentially influencing pathways related to the microvascular system and extracellular matrix.
16 citations
,
January 2021 in “BMC Genomics” This study found that high wool-producing Wan Strain Angora rabbits had higher hair follicle density and identified potential regulatory long noncoding RNAs that may influence this trait.
13 citations
,
October 2020 in “BMC Genomics” This study revealed specific patterns and potential functions of long non-coding RNAs during the hair follicle cycle of yaks, offering insights into their sequence conservation between yaks and cashmere goats.
12 citations
,
September 2018 in “Naturwissenschaften” This study found that melatonin at 0.2 g/L for 72 hours most effectively enhances cashmere growth in Liaoning cashmere goats by upregulating the lncRNA MTC, which activates NF-kB signaling.
11 citations
,
April 2017 in “Journal of The European Academy of Dermatology and Venereology” This study found that long non-coding RNAs are differentially expressed in androgenetic alopecia, suggesting potential roles in its development and novel targets for prevention and treatment.
10 citations
,
February 2019 in “Journal of Cellular Biochemistry” This study reports a complex network of blood lncRNA and associated pathways in alopecia areata but suggests further research is needed for verification and understanding of these findings.
4 citations
,
January 2023 in “Skin Appendage Disorders” This study found that patients with alopecia areata had higher serum levels of miRNA-205 and TGF-β1, but lower levels of lncRNA HOTAIR, suggesting a potential target for therapy.
2 citations
,
September 2022 in “Frontiers in veterinary science” In this study, researchers used high-throughput sequencing to explore lncRNA interactions in cashmere goat hair follicles during embryonic development, finding lncRNAs potentially regulate genes in the Wnt and PI3K-Akt pathways related to hair follicle growth.
1 citations
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January 2024 in “International journal of molecular sciences” This review outlines that in women with PCOS, microRNAs (miRNAs) are abnormally expressed in various tissues compared to those without the condition, suggesting these miRNAs as potential biomarkers and therapeutic targets, given their role in pathways critical to PCOS and potential interactions affecting reproductive outcomes.
January 2025 in “BMC Genomics” This study examined the role of long non-coding RNAs in wool fineness among Gansu alpine fine-wool sheep, identifying specific lncRNAs and target genes that may enhance wool quality.
August 2024 in “Current Issues in Molecular Biology” In this study, researchers analyzed skin tissue from two sheep breeds during the growing period and identified 56 differentially expressed lncRNAs and 616 mRNAs linked to hair follicle development, suggesting potential targets for improving sheep wool quality through genetic and molecular approaches.
This study suggests that specific genetic changes, including mutations in protein-coding genes and noncoding regions, have contributed to the evolution of hairlessness in multiple mammalian species.