6 citations
,
March 2020 in “Electronic Journal of Biotechnology” This study found that lncRNA-599554 contributes to the inductive ability of dermal papilla cells in cashmere goats by sponging miR-15a-5p, promoting Wnt3a expression, and potentially influencing hair follicle regeneration.
4 citations
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April 2021 in “Frontiers in Immunology” This study found that clusters of mRNAs and lncRNAs in the peripheral blood of PCOS patients were aberrantly expressed, and certain lncRNA-mRNA pairs in the chemokine signaling pathway may be genetically related to PCOS.
Developing microRNA-based treatments is hard but has potential.
70 citations
,
September 2008 in “PubMed” This article reviews the role of microRNAs in skin-related conditions like psoriasis and wound healing and highlights their potential as therapeutic targets and diagnostic biomarkers, without reporting new experimental results.
April 2026 in “Current Opinion in Genetics & Development” This mini-review explores how both endogenous and damage-released RNAs serve as instructional signals that influence cell identity and plasticity during tissue maintenance and repair, highlighting RNA's role as a regulator of cellular flexibility in various regenerative contexts.
39 citations
,
May 2015 in “Advanced drug delivery reviews” This review discusses skin tissue engineering and highlights the potential role of microRNAs in improving bioengineered skin equivalents, concluding that further exploration of microRNA targets could address unmet clinical needs.
June 2026 in “Frontiers in Immunology” This review synthesizes both traditional and emerging molecular mechanisms of tissue remodeling across different organs, aiming to establish a theoretical basis for precision interventions in pathological conditions, according to the authors.
November 2023 in “Elsevier eBooks” In this chapter, researchers discuss how microRNAs (miRNAs) interact with vitamin D signaling, highlighting their emerging role as mediators in vitamin D-regulated disorders and their potential for developing miRNA-based clinical applications.
3 citations
,
January 2023 in “Physiological Research” This review suggests that mesenchymal stem cells' therapeutic effects might be due to bioactive substances they release, rather than the cells themselves, highlighting the potential of the MSC secretome as a novel, cell-free therapeutic approach.
1 citations
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May 2025 in “Scientific Reports” In this study, researchers found no significant differences in serum levels of DHEAs, DHT, and testosterone between female patients with oral lichen planus and healthy controls, suggesting no neuroendocrine etiology linked to the condition.
November 2025 in “Journal of Investigative Dermatology” AMP-303 injections can increase hair growth in androgenetic alopecia with minimal side effects.
In this study, researchers found no significant differences in the serum levels of DHEAs, DHT, and testosterone between female patients with oral lichen planus and healthy controls, suggesting no neuroendocrine etiology is associated with this condition.
January 2020 in “Columbia Academic Commons (Columbia University)” This study utilized targeted genomic sequencing and whole exome sequencing to identify novel common and rare genetic variants in Alopecia Areata, revealing potential mechanisms contributing to disease susceptibility.
19 citations
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November 2020 in “Animal Genetics” This review discusses rabbit domestication and genetics, focusing on factors influencing hair coat development, and reports no new findings; the authors highlight the potential for genetic insights to enhance rabbit breeding.
20 citations
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May 2023 in “Non-coding RNA Research” This review discusses recent advancements in developing delivery systems for small interfering RNA (siRNA) to treat skin conditions, highlighting innovations like liposomes, dendrimers, cell-penetrating peptides, and spherical nucleic acid nanoparticles designed to overcome challenges of skin permeability and degradation.
4 citations
,
August 2024 in “Non-coding RNA Research” January 2026 in “Non-coding RNA Research” This study found that low-passage exosomes from dermal papilla cells enhance hair follicle stem cell proliferation and that miR-218-5p may serve as a potential biomarker and therapeutic target for hair growth.
277 citations
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July 2002 in “Molecular Endocrinology” In this study, homozygous VDR null mutant mice exhibited nonfunctional vitamin D receptors, leading to growth abnormalities and revealing the limited physiological importance of vitamin D pathways outside the classical receptor.
2 citations
,
September 2023 in “Aging” In this study, researchers found that Elastic Net DNA methylation clocks are not accurate for distinguishing between individuals or identifying health markers, but measuring biological "noise" in stable cytosines may serve as a potential biomarker of aging and disease.
8 citations
,
March 2007 in “The journal of investigative dermatology/Journal of investigative dermatology” This study reports that the near-naked hairless mutation in mice is not an allele of the Hairless gene but may involve a mutation in a linked gene or a regulatory mutation.
12 citations
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January 2000 in “Biochemical and Biophysical Research Communications” This study characterized the intron-exon organization of human keratin 15 and keratin 19 genes to aid future mutation detection analyses related to potential genetic disorders of keratinization.
This chapter reviews recent developments in vitiligo research, highlighting the role of melanocyte stem cell differentiation and oxidative stress in its management, but reports no new clinical results.
6 citations
,
May 2003 in “PubMed” This study found that DNA is present at low levels in human hair shafts, with higher amounts near the root, and that its levels decrease after surfactant washing and colorant treatments.
6 citations
,
June 2018 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that human centromeric regions exhibit large-scale haplotypes with significant diversity, including entire Neanderthal haplotypes, which may affect chromosome transmission.
27 citations
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January 2000 in “Developmental Dynamics” This study reports that a new nude allele, nu(StL), encodes a truncated Whn transcription factor affecting T-cell development and keratin gene expression, with notable differences from the original Whn(nu) mutation.
7 citations
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July 2018 in “Journal of Investigative Dermatology” This article reviews the genetic research on male androgenetic alopecia, highlighting that over 300 associated risk variants have been identified, with unclear mechanisms of action.
April 2018 in “Journal of Investigative Dermatology” In this study, the authors identified a role for hair follicles in regulating the formation and sympathetic innervation of arrector pili muscles, influencing hair follicle stem cell activity and potentially explaining hair loss associated with beta-blockers and androgenic alopecia.
178 citations
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October 2001 in “Genes & Development” This study found that the mammalian hairless gene encodes a corepressor protein that interacts with thyroid hormone receptors, providing insights into hair loss syndromes in humans and mice.
5 citations
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December 2022 in “Molecular Biology” This review examines structural elements and delivery methods for nonviral DNA- and RNA-based vectors used in gene editing, but reports no new experimental results.
August 2024 in “Journal of Animal Science and Technology” This study identified specific keratin-associated protein genes that are highly expressed in different varieties and sexes of Angora goats, providing insights for improving mohair development through targeted breeding strategies.