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Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

The enzyme 5α-reductase type 1 is important for blood vessel development and fertility in the uterus.

5-alpha reductase inhibitors can cause sexual side effects like erectile dysfunction and reduced sexual desire, sometimes lasting after stopping the drug.

The review suggests younger men taking 1 mg finasteride report more side effects, including sexual, skin, metabolic, and psychological issues.

Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.

5α-reductase inhibitors may worsen sexual drive and spontaneous erections but don't worsen existing erectile or ejaculatory problems.

Medicines for enlarged prostate may raise the risk of breast growth and tenderness but not breast cancer.

Both drugs lower DHT levels, with GI198745 being more effective.

Using 5-alpha reductase inhibitors may increase the risk of mild depression.

The document concludes that sexual and psychiatric side effects from 5-alpha-reductase inhibitors are reported, but more high-quality research is needed to understand how often they occur.

Blocking the enzyme 5α-reductase can shrink the prostate and help treat enlarged prostate issues.

Dutasteride and finasteride do not significantly affect bone density, blood fats, or blood production, but slightly lower PSA levels and minimally impact sexual function in healthy young men.

Dutasteride more effective for hair growth, but has more side effects than finasteride.

Exercise improves insulin sensitivity and hormone regulation in PCOS rats.

The enzyme type 1 5α-reductase is more active in the hair follicle's lower part than in the skin's outer layer.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Some treatments like intralesional steroids and 5α-reductase inhibitors are effective for frontal fibrosing alopecia, but more research is needed.

High testosterone to epitestosterone ratio in hair could predict male-pattern baldness.

New pregnane derivatives are effective at inhibiting an enzyme linked to hair loss and reducing oil gland activity.

Sex hormones affect reproduction, sexual development, and oral health, and it's important for dental practitioners to understand their effects and interactions.

The enzyme 5α-reductase is key in causing psychotic-like effects from sleep deprivation.

Finasteride and dutasteride are effective in treating male hair loss but can cause sexual side effects and birth defects.

Camellia oleifera seed shell polyphenols and 1,3,6-tri-O-galloylglucose can help treat hair loss by reducing certain hormones and promoting hair growth.

Some common medications can harm male fertility, but many effects can be reversed.

Finasteride effectively treats male hair loss, increasing length and thickness.

Hormones and metabolism play a complex role in prostate enlargement, and more research is needed to improve diagnosis and treatment.

The current understanding of frontal fibrosing alopecia involves immune, genetic, hormonal factors, and possibly environmental triggers, but more research is needed for effective treatments.

The composition with carnitine, thioctic acid, and saw palmetto extract may effectively reduce inflammation in hair follicle cells.

Some medications for bladder problems can cause memory issues or mood changes, and doctors should monitor these side effects.

Early diagnosis and combination therapy, especially with finasteride and dutasteride, are key to managing Frontal Fibrosing Alopecia effectively.