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Anti-IL-12/IL-23 antibody therapy effectively treats psoriasiform skin lesions in IBD patients.

The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

Melatonin in the skin helps protect against damage from stress and UV rays, and could be used to treat certain skin conditions.

Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.

Human skin can make serotonin and melatonin.

PCOS is caused by both genetics and environmental factors like diet and obesity.

AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.

Melatonin is important for skin health and protection, and can be made by the skin or applied to it.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.

Melatonin may benefit skin health and could be a promising treatment in dermatology.

Hair loss needs more research for better treatments.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.

Congenital Adrenal Hyperplasia is a genetic disorder with two forms, causing symptoms like early puberty and severe acne, but can be identified through screening and treated with glucocorticoids.

Women with PCOS have a higher risk of diabetes and heart problems, especially when they get older.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

Vitamin D is important for skin health and may affect conditions like psoriasis and hair loss, but more research is needed to understand its role fully.

Human dermal fibroblasts are the main cells targeted by a virus that can cause a deadly skin cancer, and a certain inhibitor can effectively block this infection.

Inflammation may be linked to hair loss, and targeting specific enzymes could help treat it.

Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.

Different PIN proteins affect plant root hair growth by changing how auxin is transported.

Olive oil compounds may help prevent cancer in animals, but human results are mixed.

A genetic region near the PAX1 gene is linked to a higher risk of scoliosis in females.

Both genes and environmental factors like chemicals may contribute to the increase in hypospadias, but the exact causes are still unclear.

Nerves and chemicals in the body can affect hair growth and loss.

Hair ages due to genetics and environmental factors, leading to graying and thinning, with treatments available for some conditions.

Finasteride effectively blocks rat enzymes, but with varying methods and strength.

Researchers identified genes linked to coat color, body size, cashmere production, and high altitude adaptation in goats.

Lower SHBG levels may increase the risk of PCOS.