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This study observed that acute stress in rats increased neurosteroid levels linked to enhanced GABA(A) receptor function, raising seizure thresholds, while similar effects were seen in mice with deoxycorticosterone administration.

This study demonstrated that stress-derived neurosteroid THDOC shifts from inhibiting to activating the HPA axis under stress, presenting potential therapeutic targets for stress-related disorders.

This review discusses the role of TGF-β signaling in stem cell recruitment and tissue regeneration, indicating that abnormalities in TGF-β activation contribute to various major diseases and suggesting avenues for therapeutic intervention.

This study found that neurosteroids can reorganize GABA A receptors in mice, mimicking ovarian cycle changes, with the process being mediated by neurosteroid levels rather than direct hormone receptor activation.

This review discusses the roles of Eph receptors and ephrins in various diseases, highlighting their potential as therapeutic targets, but it presents no new research findings.

This review discusses various therapeutic strategies targeting platelet-derived growth factor signaling in diseases like cancer and atherosclerosis, and evaluates existing treatments without presenting new clinical data.

This study suggests that apoE4 may contribute to cognitive decline by reducing androgen receptor levels in the brain, but androgen treatment improved memory deficits in female mice expressing human apoE4.

The document concludes that the exact way alcohol causes harm to fetal development is unknown, but it significantly affects nutrient transport to the fetus and a safe level of alcohol during pregnancy is not determined.

This article reviews the scientific exploration of Ayurvedic medicinal plants and discusses their modern applications, such as a drug developed from Commiphora wightti for lipid disorders, without reporting new clinical findings.

This study supports the conclusion that the hormetic dose-response model is the most prevalent and fundamental model in biological and biomedical sciences, applicable to a wide range of clinical conditions.

This review discusses recent strategies targeting the neuroactive steroid biosynthetic pathway to enhance neurosteroidogenesis, highlighting their potential benefits for neurodegenerative and neuropsychiatric diseases, but reports no new clinical findings.

This review discusses the isolation, structure, and bioactivity of lignans and neolignans from 2016 to mid-2018, reporting no new clinical results but highlighting their potential protective properties against diseases such as cancer and neurodegeneration.

This study found that about 80% of known fullerene-binding proteins rank in the top 10% of scorers for C60 docking sites, confirming the accuracy of the predictive model used.

This study found that midazolam, unlike clonazepam, increased neurosteroid levels and affected synaptic inhibition and plasticity in rat hippocampal neurons, suggesting unique actions via dual receptor activation.

This review proposes focusing on relationships between neuroactive steroids and psychiatric disorder symptoms, rather than relying on traditional disorder classifications, and reports no new clinical findings.

This review discusses the potential role of steroid 5α-reductase inhibitors in treating neuropsychiatric disorders related to dopaminergic hyperreactivity but reports no new clinical results.

Acne is caused by genetics, diet, hormones, and bacteria, with treatments not yet curative.

This review summarizes the role of neurosteroids in seizure disorders and highlights the potential of neurosteroid replacement therapy in epilepsy but presents no new clinical findings.

This study suggests that cerebrospinal fluid levels of the neurosteroids allopregnanolone and pregnanolone correlate negatively with PTSD and negative mood symptoms, with potential sex-specific differences in synthesis enzyme blocks.

This review discusses the potential therapeutic effects of targeting the endocannabinoid system for chemotherapy-induced peripheral neuropathy and reports no new clinical results, highlighting the need for ongoing research.

This review discusses pharmacologic treatment options for muscle-related pain conditions and notes that there is strong evidence for the efficacy of tricyclic antidepressants and muscle relaxants in specific myofascial pain syndromes, but not universally.

Human enzymes can detoxify harmful substances but might also increase their cancer risk.

This study found that progesterone pretreatment in rats potentiated the effect of ethanol on mesocortical dopamine levels, suggesting an influence of neuroactive steroids on ethanol's action.

This review summarizes the ethno-medicinal uses, phytochemical constituents, and biological activities of Acorus calamus, highlighting its potential therapeutic benefits and the importance of further scientific work on this plant.

This review discusses post-SSRI sexual dysfunction and post-finasteride syndrome, highlighting unknowns about their true incidence and underlying causes, and reports no new clinical results.

This review discusses the role of δ-subunit-containing GABA A receptors and neurosteroids in temporal lobe epilepsy, highlighting their plasticity and potential pharmacological implications, without reporting new clinical results.

The authors describe drug repurposing as a promising strategy for finding new uses for existing drugs, noting it is efficient, cost-effective, and poses lower risks than traditional drug discovery processes, potentially aiding in the treatment of rare and difficult-to-treat diseases.

This article reviews behavioral dermatology, highlighting the importance of integrating physiological, social, and environmental factors in managing dermatologic conditions with behavioral components, but reports no new clinical results.

In this study, socially defeated mice showed increased alcohol consumption, and CRF-R1 antagonism selectively reduced drinking in these mice, suggesting a potential treatment target for stress-related alcohol use disorders.

This paper discusses the limitations of clinical trials in evaluating combination treatment regimens for Alzheimer's disease and ischemic stroke, highlighting the extensive resources required for such trials.