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Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

Targeting the IL-23/IL-17 pathway effectively treats several inflammatory skin diseases.

Some viruses can cause cancer by changing cell processes and avoiding the immune system; vaccines and targeted treatments help reduce these cancers.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Antibiotics can reduce acne but may lead to resistant bacteria, and understanding the skin's bacteria is important for treatment.

Cepharanthine is a well-tolerated drug with multiple medical uses, including anti-inflammatory and anti-cancer properties.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.

Blocking the virus's entry into cells by targeting certain pathways could lead to early COVID-19 treatments.

Both vitiligo and alopecia areata involve an immune response triggered by stress and specific genes, with treatments targeting this pathway showing potential.

Short-chain fatty acids from *Cutibacterium acnes* cause skin inflammation, contributing to acne.

Cyclosporine A may help treat hair loss by blocking a protein that inhibits hair growth.

Advanced nanocarrier and microneedle drug delivery methods are more effective, safer, and less invasive for treating skin diseases.

Using CRISPR for gene editing in the body is promising but needs better delivery methods to be more efficient and specific.

There are still challenges in diagnosing and treating chronic skin diseases, but there is hope for future improvements.

The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.

Skin bacteria, specifically Staphylococcus aureus, help in wound healing and hair growth by using IL-1β signaling. Using antibiotics on skin wounds can slow down this natural healing process.

Ice-skating athletes often have skin problems due to cold, infections, and inflammation, needing careful treatment and prevention.

A new mutation in the STING protein causes a range of symptoms and its severity may be affected by other genetic variations; treatment with a specific inhibitor showed improvement in one patient.

Changes in skin microbes play a role in some skin diseases and could lead to new treatments.

New genes found linked to balding, may help develop future treatments.

RACB in barley is crucial for cell polarity and nucleus positioning, aiding fungal infection.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

The research suggests that Tourette syndrome is linked to both brain signaling and immune system pathways.

Immune cells help regulate hair growth, and better understanding this can improve hair loss treatments.

Women with PCOS have higher xanthine oxidase activity linked to inflammation and heart disease risks.

Rapamycin treatment helps with mitochondrial disease by reducing PKC levels.

The document concludes that certain mutations may contribute to the inflammation in hidradenitis suppurativa and suggests that targeting TNFα could be a treatment strategy.

Chitosan/LiCl composite scaffolds help heal deep skin wounds better.