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PPAR agonists show promise for skin conditions but need more research before being a main treatment.

Tattooing helps treat skin conditions, reconstruct nipple-areola, mark radiation fields, and locate lesions.

The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.

5α-reductase inhibitors increase the risk of sexual dysfunction, especially in men with enlarged prostate.

Minoxidil and pyrithione zinc combo most effectively increases hair density.

Finasteride reduces hair loss and treats BPH without major hormone changes, but may cause sexual dysfunction.

Some drugs may reduce prostatitis symptoms short-term with few side effects.

Stem cells help repair tissue mainly by releasing beneficial substances, not by replacing damaged cells.

5α-reductase inhibitors and alpha-1 adrenergic antagonists together effectively treat benign prostatic hyperplasia, with long-term benefits.

Dupilumab is being tested for many new skin, respiratory, and gastrointestinal conditions.

Using finasteride or dutasteride may cause long-lasting erectile dysfunction.

Finasteride improves hidradenitis suppurativa but not for child-bearing women.

Finasteride might lower the risk of low-grade prostate cancer but not high-grade cancer, while alpha-blockers might reduce high-grade cancer risk.

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

Different treatments for alopecia areata have varying success rates and side effects; intralesional steroids are most effective.

Ice-skating athletes often have skin problems due to cold, infections, and inflammation, needing careful treatment and prevention.

Men are more likely to get infectious skin diseases, while women are more prone to autoimmune and pigment-related skin conditions, influenced by biological and environmental factors.

Jojoba oil is highly valued for its diverse medicinal and industrial uses.

Scientists have created a new hair loss treatment using ultrasound to deliver gene-editing particles, which resulted in up to 90% hair regrowth in mice.

Surface-modified nanoparticles mainly use non-follicular pathways to enhance skin permeation of ibuprofen and could improve treatment for inflammatory skin diseases.

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

Dutasteride effectively treats enlarged prostate, reduces prostate cancer risk, and promotes hair regrowth with few side effects.

5-α-reductase inhibitors reduce prostate cancer risk but may cause sexual dysfunction and don't affect high-grade tumor or death rates.

Microneedle arrays with nanotechnology show promise for painless drug delivery through the skin but need more research on safety and effectiveness.

Surface Plasmon Resonance is a useful tool for studying protein interactions and has potential for future technological advancements.

Eph/ephrin signaling is important for skin cell behavior and could be targeted to treat skin diseases.

The document suggests creating a validated score to diagnose Cushing's Syndrome and considers plasma steroid profiling as a simpler diagnostic method.

Finasteride may cause suicidal thoughts and mental side effects, especially in young people with hair loss.

Some alternative treatments for hair loss might work, but more research is needed.

PFS and PSSD are similar conditions with persistent sexual dysfunction after stopping medication.