research The Relevance of Collagen XVII Expression in Epidermal Differentiation and Proliferation
Collagen XVII is crucial for skin cell growth and nail health.
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30-60 / 1000+ results research Study of New Candidate Substances for Treating Hair Loss Related to Cell Damage Caused by Intermittent Fever
Ibuprofen, menthol, and cetirizine may help prevent or slow hair loss.
research PSAT327 Can Cannabis Use Lead to Central Hypothyroidism
Marijuana use may be linked to lower TSH levels, but the exact cause is unclear.
research Bendamustine: An Old Drug in the New Era for Patients with Non-Hodgkin Lymphomas and Chronic Lymphocytic Leukemia
Bendamustine, often combined with other drugs, is effective and less toxic for certain blood cancers, but less effective for young, fit patients with CLL.
research Water Distribution in Human Hair Microstructure Elucidated by Spin Contrast Variation Small-Angle Neutron Scattering
The technique showed that human hair has two main parts, with 68% being rigid and the rest flexible, and water swelling affects its structure.
research A Peptide Derivative with Known Anti-Wrinkle Properties Identified as Potent Dipeptidylpeptidase-4 Inhibitor
A peptide known for reducing wrinkles also effectively inhibits an enzyme linked to skin inflammation and acne.
research Nonhuman Primate Dermatology: A Literature Review
The document concludes that veterinary dermatologists need more experience and a better approach to treating skin diseases in nonhuman primates.
research Long-Term COVID-19 Complications: A Multidisciplinary Clinic Follow-Up Approach
A team of different healthcare experts is good for treating long-term COVID-19 issues.
research Plain Language Summaries of Dermatology Studies
Most clinicians follow discharge guidelines, many lupus patients don't use sunscreen regularly, dithranol is effective for psoriasis, biopsy methods should be based on lesion type, voriconazole may raise skin cancer risk, a new scale can help diagnose female hair loss early, and most melanomas may develop from existing moles.
research The Only Way Is Ethics? Applying for National Health Service Ethical Approval and Governance for Research with Children
Getting ethical approval for research with children is important but can be complex and time-consuming, sometimes leading to the exclusion of certain age groups.
research Laser Treatment for Female Facial Hirsutism: Are Quality-of-Life Benefits Sustainable?
Laser hair removal improves quality of life but emotional benefits decrease over time, suggesting more treatments are needed for lasting effects.
research Influence of TRPV3 Mutation on Hair Growth Cycle in Mice
The TRPV3 gene mutation affects hair growth by keeping mice in the growth phase longer, which could help treat hair loss.
research A Primary Adrenal Non-Hodgkin's Lymphoma Presenting as an Incidental Adrenal Mass
A woman's small, unnoticed adrenal mass turned out to be a rare non-Hodgkin's lymphoma, treated successfully with surgery and therapy.
research Male Balding as a Major Risk Factor for Severe COVID-19: A Possible Role for Targeting Androgens and Transmembrane Protease Serine 2 to Protect Vulnerable Individuals
Severe male balding may increase the risk of serious COVID-19, and treatments that reduce androgens or block a specific enzyme might help protect these individuals.
research The Arabidopsis Receptor-Like Kinase CAP1 Promotes Shoot Growth Under Ammonium Stress
CAP1 helps Arabidopsis plants grow better under ammonium stress.
research Naked Hair Shafts as a Marker of Cicatricial Alopecia
Naked hair shafts are significantly associated with scarring hair loss and may help diagnose it, especially when multiple are found.
research Treatment of Corticosteroid-Refractory Alopecia Totalis with Oral Tacrolimus
Oral tacrolimus may be a potential treatment for hair loss that doesn't respond to corticosteroids.
research Low Serum Biotinidase Activity in Children with Valproic Acid Monotherapy
Children taking higher doses of valproic acid had lower biotinidase activity, which may lead to biotin deficiency, but biotin supplements could help.
research Biphasic Effects of Minoxidil on the Proliferation and Differentiation of Normal Human Keratinocytes
Minoxidil affects cell growth in two ways: low doses increase growth, while high doses slow it down and can be toxic.
research Bendamustine in Indolent Non-Hodgkin's Lymphoma: A Practice Guide for Patient Management
Bendamustine combined with rituximab is an effective and well-tolerated treatment for certain types of lymphoma.
research Enrichment and Characterization of Human Dermal Stem/Progenitor Cells Using Collagen Type IV
Scientists identified a group of human skin cells with high growth and regeneration potential.
research Human Keratinocytes Derived from the Bulge Region of Hair Follicles Are Refractory to Differentiation
Hair follicle cells resist turning into skin cells.
research Protective Effect of Iris Germanica L. Rhizome-Derived Exosome Against Oxidative-Stress-Induced Cellular Senescence in Human Epidermal Keratinocytes
Iris germanica rhizome-derived exosomes help protect skin cells from oxidative stress and aging.
research Abstract 2474: The Mechanistic Role of Polyamines in DNA Double-Strand Break Repair
The study explored the role of polyamines in DNA double-strand break (DSB) repair, particularly focusing on their involvement in the homologous recombination (HR) repair pathway rather than non-homologous end joining (NHEJ). It was found that polyamines enhance the RAD51-mediated DNA strand exchange reaction by improving duplex DNA capture, which is crucial for the repair process. The research utilized biochemical analyses, cell-based experiments, and an animal model using mouse hair follicles to demonstrate the physiological significance of polyamines in DNA repair. These findings provided valuable insights into the mechanistic role of polyamines in DNA repair, highlighting their potential impact on tumorigenesis due to their increased levels in many cancers.
research Incidence of Type 2 Diabetes Mellitus in Men Receiving Steroid 5α-Reductase Inhibitors: Population-Based Cohort Study
Men taking dutasteride or finasteride have a slightly higher risk of developing type 2 diabetes.
research Alopecia Areata Is Associated With Increased Expression of Heart Disease Biomarker Cardiac Troponin I
People with alopecia areata have higher levels of a heart disease marker than those without hair loss.
research Uncharted Waters: The Impact of NGS and Machine Learning on Forensic Science
New DNA analysis and machine learning are advancing forensic science, improving accuracy and expanding into non-human applications.
research P4 Outcome Following Switch Between Brand Name And Generic Tacrolimus In Paediatric Population
Switching to generic tacrolimus was safe, effective, and saved money.
research Antizyme Release Is an Early Event in Ornithine Decarboxylase Induction by Hair Plucking
Hair plucking in rats led to a rapid decrease in ornithine decarboxylase (ODC) activity, while other skin enzymes remained unaffected. The study suggested the presence of an inhibitor, known as antizyme, which was released early during the induction of ODC by hair plucking. Treatment with 10% (NH4)2SO4 increased ODC activity by approximately 75% in enzyme preparations, indicating that antizyme levels increased in plucked skin extracts after such treatment.
research Finasteride Delays Atherosclerosis Progression in Mice and Is Associated With a Reduction in Plasma Cholesterol in Men
Finasteride may lower cholesterol and slow heart disease progression.