13 citations,
December 2014 in “Stem Cells” Hair and skin can regenerate without bulge stem cells due to other compensating cells.
10 citations,
November 2022 in “Protein & Cell” Quercetin significantly helps hair growth by activating hair follicles and improving blood vessel formation around them.
10 citations,
October 2020 in “Frontiers in Cell and Developmental Biology” Wounds can regenerate hair in young mice, but this ability declines with age, offering insights for improving tissue regeneration in the elderly.
10 citations,
May 2020 in “Journal of Dermatological Treatment” Microneedling with 5% minoxidil improves hair loss in Chinese men by activating Wnt/ß-catenin pathway.
10 citations,
September 2018 in “Regenerative Medicine” New hair can grow from large wounds in mice, but less so as they age, involving reprogramming of skin cells and specific molecular pathways.
10 citations,
January 2013 in “Journal of skin cancer” PKC ε increases hair follicle stem cell turnover and may raise skin cancer risk.
9 citations,
November 2019 in “Cell calcium” The STIM1 R304W mutation in mice leads to bone changes and teeth hair growth.
9 citations,
January 2017 in “Elsevier eBooks” Skin's epithelial stem cells are crucial for repair and maintenance, and understanding them could improve treatments for skin problems.
7 citations,
August 2022 in “Nature communications” A specific group of slow-growing stem cells marked by Thy1 is crucial for skin maintenance and healing in mice.
7 citations,
July 2020 in “Pigment cell & melanoma research” RT1640 treatment reverses gray hair and promotes hair growth in mice.
7 citations,
October 2018 in “BMC genomics” Key genes can rewire networks, changing skin appendage types.
6 citations,
July 2023 in “Nature cell biology” SOX9 helps determine stem cell roles by interacting with DNA and proteins that control gene activity.
6 citations,
December 2021 in “PLoS Genetics” Polycomb Repressive Complex 2 is not needed for hair regeneration.
6 citations,
January 2017 in “Advances in Experimental Medicine and Biology” Runx genes are important for stem cell regulation and their roles in aging and disease need more research.
6 citations,
October 2012 in “Journal of Heredity” The Itpr3 gene causes a specific hair pattern in mice.
5 citations,
May 2020 in “Life science alliance” Removing integrin α3β1 from hair stem cells lowers skin tumor growth by affecting CCN2 protein levels.
5 citations,
October 2014 in “Methods” The document explains how to create detailed biological pathways using genomic data and tools, with examples of hair and breast development.
4 citations,
January 2020 in “Cells” The research found that the gene activity in mouse skin stem cells changes significantly as they age.
4 citations,
July 2014 in “Journal of Investigative Dermatology” Old people have less hair because their hair follicles don't regenerate as well, not because of fewer stem cells, and a protein called follistatin might help reactivate hair growth.
3 citations,
January 2024 in “Signal transduction and targeted therapy” Lymphatic vessels are essential for health and can be targeted to treat various diseases.
3 citations,
January 2023 in “Physiological Research” Conditioned media from mesenchymal stem cells show promise for tissue repair and disease treatment, but more research is needed on their safety and effectiveness.
3 citations,
August 2013 in “Stem cells” Certain inhibitors applied to the skin can promote hair growth by maintaining a key hair growth signal.
2 citations,
May 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” Stem cells help remove dead cells to keep tissues healthy by balancing cell replacement and clearance.
2 citations,
March 2020 in “Cell” Elaine Fuchs' research shows how skin stem cells maintain health, aid in healing, and are involved in cancer.
1 citations,
March 2024 in “Signal transduction and targeted therapy” NF-κB signaling is crucial in many diseases and can be targeted for new treatments.
1 citations,
September 2023 in “eLife” TLR2 is important for hair growth and can be targeted to treat hair loss.
1 citations,
August 2023 in “Nature communications” Hdac1 and Hdac2 help maintain and protect the cells that control hair growth.
1 citations,
April 2021 in “Current Stem Cell Reports” Eating less can improve stem cell function and increase lifespan.
1 citations,
January 2021 CD4+ skin cells may be precursors to basal cell carcinoma.
1 citations,
January 2018 in “Stem cell biology and regenerative medicine” DNA methylation is essential for skin and hair follicle development, and could be a target for treating skin diseases.