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The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Neuroactive steroids may affect the risk and treatment of alcohol use disorders.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

Postpartum depression is linked to changes in brain chemicals, inflammation, stress, and certain genes, and can potentially be identified by markers like specific steroids, serotonin levels, and vitamin D levels.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

The protein StAR is found in 17 different organs and can affect hair loss and brain functions, but its full role is not yet fully understood.

Progesterone boosts alcohol's effect on brain, finasteride counters it.

PFS and PSSD are similar conditions with persistent sexual dysfunction after stopping medication.

5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.

Some hormone-related drugs may protect brain cells in Parkinson's disease differently in men and women.

Neuroactive steroids could become safe, effective treatments with more understanding of their complex brain actions and metabolism.

Finasteride blocks progesterone's effect on absence seizures in rats.

Finasteride slows down motherly behavior in first-time pregnant rats.

Finasteride may cause lasting sexual, mental, and physical symptoms; use with caution.

Blocking 5α-reductase can harm memory and brain structure, and increase harmful brain changes in male mice used for Alzheimer's disease research.

Finasteride helps reduce pain and inflammation in animals.

Finasteride affects SRD5A2 gene pattern, possibly causing lasting side effects.

Finasteride can cause lasting sexual dysfunction, depression, and other side effects, needing more research for treatment.

Finasteride may increase suicide risk; more research needed.

Paeoniflorin protects brain cells by involving a specific protein and neurosteroids.

Finasteride helps treat eyelid spasms.

Female rats showed more panic-related behavior than males, influenced by hormonal cycles and certain drugs.

Early NAS level changes affect alcohol consumption vulnerability.

The research identified and described a gene important for hormone conversion in endangered catfish, which varies in activity during different reproductive stages and after hormone treatment.

Finasteride might affect memory by impacting cholinergic system.

Finasteride, a drug used for certain conditions, can cause serious side effects like sexual dysfunction, suicidal thoughts, and increased diabetes risk, and there's a need for more awareness and research about these effects.

5-alpha reductase inhibitors, like finasteride and dutasteride, may cause depression, but more research is needed to understand why.

Dutasteride may help protect neurons and reduce inflammation in Parkinson's disease.