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Knuckle darkening can be an early sign of vitamin B12 deficiency.

Extended-release divalproex is better tolerated and more effective for seizures and psychiatric symptoms than delayed-release divalproex, but doesn't reduce hair loss.

Sleep problems and skin issues affect each other; poor sleep can worsen skin conditions, and some skin treatments can improve or harm sleep quality.

Sodium valproate can cause reversible hair loss in some patients.

A specific genetic change is linked to mental disorders, intellectual disability, and possibly autoimmune disease in a family.

Most legal cases about 5α-reductase inhibitors, drugs for hair loss and prostate issues, complain about side effects and delayed cancer diagnosis, with most lawsuits settled out of court.

Valproic acid and carbamazepine do not change biotin or biotinidase levels but may lower zinc levels, still within normal range.

A clinical nutrition program improved sensory and motor function in a 60-year-old with anti-MAG neuropathy.

A 19-year-old male with delayed puberty was successfully treated for a condition that prevents normal hormone production.

Finasteride for hair loss may cause persistent sexual symptoms, depression, anxiety, and lower quality of life.

Monitoring new epilepsy drugs after they're sold is crucial to find rare and long-term side effects that initial tests might miss.

PCOS treatment should address both symptoms and metabolic risks, starting with lifestyle changes and possibly including medication.

Mood stabilizers like lithium and anticonvulsants have side effects that can lead to patients stopping their medication, and managing these effects is important for treatment adherence.

A patient with a larger than usual genetic mutation had a broader range of symptoms for a muscle disease.

Some skin disorders might be linked to H. pylori infection, but more research is needed to confirm this.

The document concludes that accurate diagnosis of hair loss in children is crucial due to limited treatment options and the condition's psychological impact.

Extended-release valproate effectively reduced seizures and improved quality of life in epilepsy patients over 6 months, with some side effects.

Spironolactone might cause painful intercourse and decreased sexual arousal in women.

SLE is rare in Uganda but often has complications and overlaps with rheumatoid arthritis.

Hyaluronic acid filler can safely and effectively improve facial contour in Parry-Romberg Syndrome.

An 11-year-old girl with a rare skin disorder also had cornea issues and dry eye, needing careful management.

A girl with hereditary chorea, likely Huntington's disease, had her condition worsened by lupus.

A 16-year-old boy with lupus had a rare brain artery issue but fully recovered with treatment.

A boy with progeria had eye problems and signs of aging like hair loss and skin wrinkling.

Spironolactone can cause side effects like high potassium levels and breast enlargement, and patients need careful monitoring.

Patients who survive critical illness often face long-lasting physical, mental, and cognitive issues, with many unable to return to work within a year.

Yellow dots look different in various hair loss conditions and can help diagnose them.

The document concludes that detailed clinical descriptions of seven family cases help understand dominant dystrophic epidermolysis bullosa's symptoms and inheritance.

A man with Klinefelter syndrome had a leg ulcer that didn't heal well, even with treatment.

Some people have severe allergic reactions to anthelminthic drugs, but these are often due to the parasites, not the drugs.