June 2023 in “Frontiers in Bioengineering and Biotechnology” The conclusion is that accurately replicating the complexity of the extracellular matrix in the lab is crucial for creating realistic human tissue models.
This study examined the effects of neurosteroids on oxytocin (OT) secretion in 36 luteal-phase and pregnant sheep under basal and stress conditions. Allopregnanolone (AL) was found to inhibit stress-induced OT secretion in non-pregnant sheep, while blocking neurosteroid synthesis with finasteride increased both basal and stress-induced OT secretion in pregnant sheep. The results suggest that neurosteroids play a crucial role in regulating OT secretion, particularly under stress and pregnancy conditions, potentially protecting the fetus from premature labor.
April 2011 in “한국생물공학회 학술대회” Lotion with fucoidan from brown seaweed improved skin and reduced allergy symptoms in mice with dermatitis.
March 2023 in “International Journal of Molecular Sciences” ADSC-Exos with miR-122-5p can help treat hair loss by promoting hair growth.
December 2022 in “Nature Communications” The study introduces a bead-jet printing system for sparse mesenchymal stem cell (MSC) patterning, significantly enhancing skeletal muscle and hair follicle regeneration. Using Matrigel beads to encapsulate MSCs, the system improves cell retention, proliferation, and migration compared to traditional methods. High-density MSCs in sparse patterns among acellular beads provide superior therapeutic outcomes, reducing the number of MSCs needed for effective treatment. The method activates the PI3K-Akt and Wnt/β-CATENIN signaling pathways, leading to better muscle regeneration with less fibrosis and improved skin healing with increased hair follicle formation. The findings suggest that bead-jet printing of MSCs in high-density patterns can significantly enhance tissue regeneration outcomes, making it a promising approach for large-scale traumatic injury therapy.
November 2022 in “Journal of Nanobiotechnology” The developed system could effectively treat hair loss and promote hair growth.
January 2015 in “American journal of medical and biological research” December 2022 in “Regenerative Therapy” 5 citations,
June 2019 in “Journal of lipid research” New probes were created to effectively measure specific enzymes involved in fat metabolism, which could help develop new drugs.
11 citations,
August 2018 in “Asian-Australasian journal of animal sciences” Short daily photoperiods improve cashmere production in Inner Mongolia white cashmere goats.
9 citations,
August 2018 in “Acta biomaterialia” Eyelash curvature is linked to the thickness of the cuticle layer at the root.
36 citations,
March 2011 in “Nature Communications” Cells from a skin condition can create new hair follicles and similar growths in mice, and a specific treatment can reduce these effects.
9 citations,
July 2002 in “Journal of the European Academy of Dermatology and Venereology” The document concludes that fexofenadine reduces inflammation in chronic hives, cholestyramine helps half of pregnant women with itchy rashes, and relaxing incisions are a good alternative in facial surgery for the elderly.
40 citations,
May 1987 in “The Lancet” Minoxidil helps some bald men, but most lose hair again when stopping.
20 citations,
June 2022 in “Molecules” Thiazole, a sulfur and nitrogen chemical, is useful in creating potential drugs for conditions like seizures, cancer, bacterial infections, tuberculosis, inflammation, malaria, viruses, Alzheimer's, diabetes, and A1-receptor issues.
81 citations,
July 2007 in “Fertility and Sterility” Testosterone therapy seems safe for postmenopausal women for a few years, but more research is needed for long-term effects.
66 citations,
February 2010 in “CrystEngComm” Made 8 minoxidil samples; 1 cocrystal, 7 salts formed.
4 citations,
June 2013 in “The Journal of Rheumatology” The document concludes that various findings in rheumatology offer insights into disease severity, treatment responses, and potential risks in medication, with some limitations due to unspecified participant numbers.
1 citations,
February 2021 in “Animal feed science and technology” Organic selenium may offer better retention and less waste in puppies.
June 2022 in “International Journal for Research in Applied Science and Engineering Technology” The herbal shampoo made from Piper Betel and Psidium Guajava leaves was safe, promoted hair growth, and reduced hair fall.
March 2010 in “Anti-inflammatory & anti-allergy agents in medicinal chemistry” Biologic agents can be effective for rheumatic diseases but have risks like infections and require careful monitoring and patient information.
1 citations,
December 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” Choosing the right method to separate skin layers is key for good skin cell research.
9 citations,
June 2008 in “Journal of Clinical Oncology” A woman's ovarian tumor causing high testosterone was successfully removed, and her symptoms improved.
20 citations,
December 2021 in “Plants” Tamarix aphylla may be effective for various medical conditions, but more research is needed to confirm its safety and effectiveness.
March 2024 in “Animal nutrition” Adding both soluble and insoluble fibers, especially beet pulp, to the diet of pregnant sows helps improve their health and the growth of their piglets in hot weather.
The review highlights the potential of natural products in treating hair loss by activating the Wnt/β-catenin signaling pathway, which is crucial for hair follicle development, hair cycle regulation, and hair regeneration. Traditional treatments like finasteride and minoxidil have limitations, prompting research into natural compounds such as polyphenols, which show promise in promoting hair growth with fewer side effects. Key natural products identified include extracts from Aconitie Ciliare Tuber, Centipeda minima, Ginkgo biloba, Malva verticillata, and Prunus mira, which enhance β-catenin activity and other growth factors in dermal papilla cells. These findings suggest that natural products could offer safer and effective alternatives for hair loss treatment, with future research needed to explore clinical applications and potential combinations with existing drugs.
January 2024 in “Journal der Deutschen Dermatologischen Gesellschaft” Non-biologic immunosuppressive drugs are crucial for treating autoimmune and chronic inflammatory skin diseases.
70 citations,
June 1993 in “Biochemistry” Finasteride slowly binds to 5-alpha-reductase, affecting enzyme stability and inhibitor potency.
32 citations,
January 2021 in “Molecules” Some Middle Eastern plants may help treat diabetes and could be alternatives to current drugs, but more research is needed.
14 citations,
May 2021 in “Marine Drugs” PDRN, derived from salmon sperm, shows promise in healing wounds, reducing inflammation, and regenerating tissues, but more research is needed to understand its mechanisms and improve its use.