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    Glossary Neural Crest Stem Cells

    originate from the neural crest and can become various cell types

    Neural Crest Stem Cells (NCSCs) are a type of multipotent stem cell that originate from the neural crest, a transient structure in vertebrate embryos. These cells have the remarkable ability to differentiate into a diverse range of cell types, including neurons, glial cells, melanocytes, and even some types of connective tissue. This versatility makes them crucial for the development of various tissues and organs, and they are a significant focus in regenerative medicine and developmental biology research.

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    1. Convergent Genesis of an Adult Neural Crest-Like Dermal Stem Cell from Distinct Developmental Origins Stem cells · 2010 · 106 citations
    2. Canine Epidermal Neural Crest Stem Cells: Characterization and Potential as Therapy Candidate for a Large Animal Model of Spinal Cord Injury Stem Cells Translational Medicine · 2014 · 17 citations
    3. Comparative Analysis of Biological Properties of Large-Scale Expanded Adult Neural Crest-Derived Stem Cells Isolated from Human Hair Follicle and Skin Dermis Stem cells international · 2019 · 11 citations
    4. Multipotent Neural Crest Stem Cell-Like Cells from Rat Vibrissa Dermal Papilla Induce Neuronal Differentiation of PC12 Cells BioMed research international · 2014 · 10 citations
    5. Generation of Induced Pluripotent Stem Cells from Hair Follicle Bulge Neural Crest Stem Cells Cellular reprogramming · 2014 · 3 citations
    6. The Role of miR-214-3p in Hair Follicle Neural Crest Stem Cell-derived Exosomes in the Repair of Peripheral Nerve Injury 2025
    7. Induction of osteoblastic differentiation of neural crest-derived stem cells from hair follicles PLoS ONE · 2017 · 17 citations
    8. EGF–FGF2 stimulates the proliferation and improves the neuronal commitment of mouse epidermal neural crest stem cells (EPI-NCSCs) Experimental Cell Research · 2014 · 29 citations
    9. Human Epidermal Neural Crest Stem Cells (hEPI-NCSC)—Characterization and Directed Differentiation into Osteocytes and Melanocytes Stem Cell Reviews and Reports · 2011 · 91 citations
    10. Mouse Epidermal Neural Crest Stem Cell (EPI-NCSC) Cultures Journal of Visualized Experiments · 2008 · 14 citations
    11. Human epidermal neural crest stem cells as candidates for cell-based therapies, disease modeling, and drug discovery Birth defects research · 2014 · 13 citations
    12. Investigating the synergic effects of valproic acid and crocin on BDNF and GDNF expression in epidermal neural crest stem cells Acta Neurobiologiae Experimentalis · 2020 · 10 citations
    13. Prenatal transplantation of epidermal neural crest stem cells in malformation of cortical development mouse model Microscopy Research and Technique · 2016 · 5 citations
    14. Mouse Epidermal Neural Crest Stem Cell (EPI-NCSC) Cultures Journal of Visualized Experiments · 2008 · 3 citations
    15. [Transplanted epidermal neural crest stem cell in a peripheral nerve gap]. PubMed · 2014 · 2 citations
    16. Olig2 positive cells derived from hair follicle neural crest stem cells in rats Journal of chemical neuroanatomy · 2020
    17. Exosomes from Hair Follicle Epidermal Neural Crest Stem Cells Promote Acellular Nerve Allografts to Bridge Rat Facial Nerve Defects Stem Cells and Development · 2022
    18. The Suppression Effects of Fat Mass and Obesity Associated Gene on the Hair Follicle-Derived Neural Crest Stem Cells Differentiating into Melanocyte by N6-Methyladenosine Modifying Microphthalmia-Associated Transcription Factor International Journal of Stem Cells · 2023 · 4 citations
    19. Differentiation of cultured hair follicle neural crest stem cells into functional melanocytes Heliyon · 2024 · 1 citations
    20. Human epidermal neural crest stem cells as a source of Schwann cells Development · 2015 · 44 citations
    21. Pluripotent Hair Follicle Neural Crest Stem-Cell-Derived Neurons and Schwann Cells Functionally Repair Sciatic Nerves in Rats Molecular Neurobiology · 2009 · 36 citations
    22. Construction of Tissue-Engineered Nerve Conduits Seeded with Neurons Derived from Hair-Follicle Neural Crest Stem Cells Methods in molecular biology · 2016 · 7 citations
    23. Experimental dataset for: Hair follicle neural crest stem cell-derived exosomes promote peripheral nerve regeneration via miR-214-3p Mendeley Data · 2026
    24. Dataset of figures and summary tables supporting the review: "The Role and Mechanism of Hair Follicle Neural Crest Stem Cells and Their Exosomes in Repair of Peripheral Nerve Injury" Mendeley Data · 2026
    25. Dataset of figures and summary tables supporting the review: "The Role and Mechanism of Hair Follicle Neural Crest Stem Cells and Their Exosomes in Repair of Peripheral Nerve Injury" Mendeley Data · 2026
    26. Dataset of figures and summary tables supporting the review: "The Role and Mechanism of Hair Follicle Neural Crest Stem Cells and Their Exosomes in Repair of Peripheral Nerve Injury" Mendeley Data · 2026
    27. Experimental dataset for: Hair follicle neural crest stem cell-derived exosomes promote peripheral nerve regeneration via miR-214-3p Mendeley Data · 2026
    28. Dataset of figures and summary tables supporting the review: "The Role and Mechanism of Hair Follicle Neural Crest Stem Cells and Their Exosomes in Repair of Peripheral Nerve Injury" Mendeley Data · 2026
    29. Inhibition of the Hippo pathway by verteporfin reduces the proliferation and stemness of rat hair follicle neural crest stem cells under hypoxia FASEB BioAdvances · 2025
    30. The Role of miR-214-3p in Hair Follicle Neural Crest Stem Cell-derived Exosomes in the Repair of Peripheral Nerve Injury 2025