5 citations
,
August 2005 in “Anatomy and Embryology” This study found that concentrated clusters of noradrenergic nerve fibers form a longitudinal linear system in rat skin, particularly innervating arrector pili muscles.
3 citations
,
June 2023 in “MedComm” This study summarizes the role and potential applications of stem cell exosomes in skin and bone healing, highlighting their regenerative capabilities and suggesting innovative delivery methods like nanoliposomes and hydrogels to improve bioavailability and therapeutic outcomes.
3 citations
,
May 2013 in “International journal of molecular sciences” This review discusses the biological characteristics and potential of epidermal stem cells in orthopedic regenerative medicine but reports no new experimental findings.
3 citations
,
January 2017 in “Journal of cardiovascular pharmacology” This article discusses the challenges in hypertension management, emphasizing the need to reconsider the use of minoxidil and address excess dietary sodium and arteriolar hypertrophy, but reports no new clinical results.
1 citations
,
October 2023 in “Heliyon” In this study, the researchers reported a new case of Hutchinson-Gilford progeria syndrome with a novel LMNA mutation and successful surgical intervention for airway obstruction.
April 2026 in “IntechOpen eBooks” This study reviews the complexities of burn-related skin complications, highlighting postburn pruritus, dyspigmentation, and the risk of malignant ulcers, while offering a framework for evidence-based management through various treatment approaches.
June 2025 in “Materials Today Bio” In this study, a silk fibroin hydrogel containing recombinant NT3 was found to promote scar-less wound healing in a mouse skin injury model by enhancing type III collagen expression and inducing hair follicle formation.
48 citations
,
December 2022 in “Biomolecules” This review discusses recent advancements in 3D bioprinting for skin regeneration and describes potential improvements for clinical applications, but it reports no new experimental results.
12 citations
,
January 2011 in “Journal of the Saudi Society of Dermatology & Dermatologic Surgery” This study documented an outbreak of thallium poisoning in Iraq, highlighting its dermatological, neurological, and psychological signs, which are crucial for accurate diagnosis.
9 citations
,
November 2024 in “Biotechnology for Sustainable Materials” This paper critically reviews recent advances in the use of keratin-based biomaterials, highlighting their potential applications in wound healing, drug delivery, and tissue regeneration due to their biocompatibility, biodegradability, and ability to support cell growth.
This study in adult mice found that somatosensory axons innervating Merkel cells in the skin are highly plastic, with significant remodeling in response to epithelial turnover, and that Merkel cells play a role in limiting axonal branching and promoting their maturation.
57 citations
,
October 2021 in “Journal of ethnopharmacology” This review compiled by the authors emphasizes the traditional use of medicinal plants for dermatological disorders in India, highlighting the need for further scientific studies to validate their effectiveness and suggesting potential for drug development based on ethnodermatological practices.
1 citations
,
October 2022 in “Annual review of cell and developmental biology” This review discusses the roles of peripheral nerves in stem cell and immune responses within the skin and hematopoietic system, emphasizing their potential in developing new therapies; it reports no new experimental results.
In this study, rat vibrissa follicles transplanted into mice demonstrated survival, partial sympathetic nerve reinnervation, and increased norepinephrine levels 37 days post-implantation, suggesting potential for hair growth despite not returning to normal nerve function.
45 citations
,
September 2000 in “Archives of dermatology” This study found that 5alpha-reductase type 1 localizes specifically to sebaceous glands in both normal and acne follicles, suggesting its role in sebum regulation.
5 citations
,
February 2015 in “Egyptian Journal of Ear Nose Throat and Allied Sciences” This case report describes an ossifying pilomatrixoma found in a 15-year-old girl, confirmed via histopathological examination after imaging indicated a subcutaneous mass on her cheek.
1 citations
,
April 2025 in “Pigment Cell & Melanoma Research” This article reviews the underlying mechanisms of segmental vitiligo with white hair, focusing on skin and hair follicle melanocytes, and proposes potential targets for treatment, highlighting neuroendocrine factors as possible contributors to the condition.
February 2024 in “Genes to Cells” This study observed that tooth loss in mice led to premature graying of hair in the interbrow region, which was possibly due to reduced stimulation of the trigeminal nerve, suggesting that decreased mastication could cause this type of hair graying.
November 2023 in “Advanced functional materials” This study suggests that inorganic magnesium silicate sprays can improve burn wound repair and promote regeneration of skin appendages, showing superior results compared to commercial wound healing products in animal models.
47 citations
,
November 1982 in “Journal of Cardiovascular Pharmacology” Nitrendipine and nifedipine effectively block muscle contractions, while papaverine relaxes them and minoxidil needs high amounts to work.
January 2012 in “Journal of Investigative Dermatology” The document presented various studies on hair and cutaneous development, revealing insights into hair biology and potential therapeutic targets for hair-related conditions. Key findings included the role of stem cells and their niches in hair regeneration, the impact of TACE/ADAM17 depletion on alopecia, and the expression of somatostatin in hair follicles. Research on genetic factors, such as CYLD mutants and P-cadherin, highlighted their importance in hair growth and pigmentation. Studies on hair aging identified genes involved in hair loss in women over 40. Additionally, the potential of keratinocyte precursors from iPS cells for hair follicle regeneration and the effectiveness of a parathyroid hormone analog in reversing chemotherapy-induced alopecia were explored. The document also discussed the role of cholesterol biosynthesis in cicatricial alopecia, the necessity of Wnt signaling for hair follicle initiation, and the effects of ATP-sensitive potassium channel blockers on hair growth. These findings collectively advanced the understanding of hair growth, alopecia treatment, and skin regeneration.
10 citations
,
June 2007 in “Journal of Oral and Maxillofacial Surgery” A man's rare tumor caused unusual nerve-related symptoms that improved after surgery.
2 citations
,
October 2012 in “Cutaneous and Ocular Toxicology” This study suggests that glaucoma patients may face increased risk of optic nerve injury if prescribed medications that can lower blood pressure.
April 2018 in “Journal of Investigative Dermatology” In this study, the authors identified a role for hair follicles in regulating the formation and sympathetic innervation of arrector pili muscles, influencing hair follicle stem cell activity and potentially explaining hair loss associated with beta-blockers and androgenic alopecia.
1 citations
,
January 2008 in “Springer eBooks” This study found that hair follicle stem cells are multipotent and can enhance nerve regeneration and function in mice, showing potential as an accessible source for treating peripheral nerve injuries.
60 citations
,
January 1989 in “Toxicologic Pathology” This paper discusses the pathogenesis of cardiovascular lesions in dogs associated with minoxidil, noting that lesions were not prevented by adrenergic blockade or neural activity suppression, and highlights the differences in injury progression between coronary arteries and the right atrium.
54 citations
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October 2019 in “Cochrane library” This study found low- to very low-quality evidence suggesting that several pharmacological treatments, including alpha blockers and antibiotics, may reduce prostatitis symptoms without significantly increasing adverse events in the short term, although more rigorous trials are needed.
3 citations
,
January 2003 in “Cell Structure and Function” This study found that Meth-A cells induced alopecia in mice, but this effect was blocked by a protein kinase inhibitor, suggesting immunological mechanisms involving lymphokine-activated killer cells.
This study found that MEIS2 expression in neural crest-derived cells is crucial for whisker and trigeminal nerve development in the mesenchyme, indicating an early role in epithelial placode formation and dermal condensation, independent of sensory innervation or Foxd1 expression.
January 2018 in “The journal of the convergence on culture technology” This study observed that applying astringent persimmon fruit extract may significantly enhance hair growth and lengthen the hair in genetically balding Black mice.