February 2024 in “Curēus” In this study, researchers found that using regional nerve blocks (STN and SON blocks) for anesthesia in platelet-rich plasma treatment for hair regrowth resulted in significantly less pain and better analgesia compared to the more common ring block technique.
This study found that follicular unit extraction can be safely performed without bupivacaine and nerve blocks, using lignocaine with adrenaline as an effective anesthetic for patients with certain grades of androgenetic alopecia.
1 citations
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September 2017 in “Dermatologic Surgery” The cephalic approach for nerve blocks is less painful than the anterior approach during hair restoration surgery.
March 2025 in “Pain Physician” This retrospective study found that applying local skin precooling before scalp nerve block significantly reduced injection site pain during PRP mesotherapy for patients with androgenetic alopecia, compared to those who did not receive precooling, thus improving patient comfort and compliance.
January 2019 in “Headache” This source discusses the use of nerve blocks as potential treatments for head and neck neuralgias and primary headaches, highlighting their effectiveness and various applications, including during intervals between onabotulinum toxin A injections.
November 2017 in “The Philippine journal of veterinary medicine/Philippine Journal of Veterinary Medicine” This study found that aquapuncture analgesia using chili pepper decoction resulted in more complete wound healing and increased hair growth compared to distal paravertebral nerve block in goats after exploratory laparotomy.
December 2024 in “African Journal of Biomedical Research” This study reported that the combined use of dexmedetomidine and ketamine, along with peripheral nerve blocks, provided adequate sedation and analgesia with maintained hemodynamic stability in patients undergoing minor surgical procedures like split skin grafting.
39 citations
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October 2012 in “Headache The Journal of Head and Face Pain” This study reports cutaneous atrophy and alopecia in four patients following greater occipital nerve blockade with triamcinolone and lidocaine, suggesting that alternative steroids may reduce these side effects.
1 citations
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January 2010 in “Elsevier eBooks” The document concludes that local flaps are effective for reconstructive surgery in the head and neck, offering good skin match and function.
April 2024 in “Asian Journal of Medical Sciences” This study found that ring block anesthesia was the most acceptable method for reducing pain during platelet-rich plasma injections for hair loss.
March 2024 in “Asian journal of medical sciences” In this study, researchers found that a ring block technique was the most accepted anesthesia modality for platelet-rich plasma injections in hair loss treatment, with the least post-procedural pain compared to other methods like vibration anesthesia and nerve blocks.
December 2023 in “Facial Plastic Surgery” This research outlined techniques for local anesthesia in follicular unit excision hair transplantation, highlighting that using ring blocks can significantly reduce pain and enhance patient comfort, making it the preferred method over nerve blocks unless ring blocks are insufficient.
October 2023 in “Facial Plastic Surgery” This article reviews local anesthesia techniques for Follicular Unit Excision (FUE) hair transplantation, noting that ring blocks are preferred due to their simplicity, effectiveness, and safety, while nerve blocks are used when additional anesthesia is needed.
In this study, researchers found that adding zygomaticotemporal nerve blocks to supratrochlear and supraorbital nerve blocks in mesotherapy lowered pain significantly during and after the procedure for hair regrowth in alopecia patients.
April 2023 in “IntechOpen eBooks” This review discusses neuropathic pruritus, detailing its clinical presentations and management strategies, but reports no new clinical results.
The man's scalp tightness after hair surgery affects his life and work, and it's unclear if it's due to the surgery or a mental health issue.
October 2022 in “Hair Transplantation” This source emphasizes the importance of understanding scalp anatomy for surgeons performing aesthetic and reconstructive procedures, as such knowledge aids in planning, predicting challenges, and avoiding complications during surgery.
1 citations
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February 2025 in “Scientific Reports” In this study, researchers developed a three-dimensional ultrastructural analysis tool using serial block-face scanning electron microscopy to reveal detailed nerve networks and muscle structures in human skin tissues, demonstrating the technique's potential to study structural changes in aging or disease.
April 2021 in “Indian Journal of Animal Research” This study examined the age-related changes in the dermal structure of goat skin, providing baseline data on its histomorphology, histochemistry, and histoenzymology.
March 2022 in “Research Square (Research Square)” This study found that 4-aminopyridine significantly improved skin wound healing by enhancing wound closure, tissue regeneration, and cellular interactions involved in repair processes.
November 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that 4-aminopyridine, a potassium channel blocker, greatly improves skin wound healing by accelerating wound closure, enhancing tissue regeneration, and promoting hair follicle neogenesis.
November 2021 in “Research Square (Research Square)” This study found that 4-aminopyridine significantly improves skin wound healing by enhancing various cellular and molecular processes, suggesting its potential for rapid translational development in wound treatment.
March 2024 in “Likarska sprava” This source reviewed contemporary methods of local anesthesia for hair transplantation, highlighting current innovations and identifying key areas for improvement and the integration of various techniques within practical trichology and plastic surgery.
March 2018 in “Journal of Pakistan Association of Dermatology” This study found that using vibration during supraorbital/supratrochlear nerve blocks in hair restoration surgery significantly reduced pain levels compared to not using vibration, with patients reporting lower Wong-Baker Faces Pain scores when vibration was applied.
83 citations
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September 2021 in “Advanced functional materials” This study introduced a multifunctional DNA hydrogel dressing that may enhance wound healing by promoting tissue regeneration, nerve repair, and immune response in diabetic infectious wounds.
May 2026 in “Nature Communications” In this study, researchers identified that keloid fibroblasts respond to neurotransmitters from catecholaminergic nerves by producing bone matrix proteins, mediated by β1-adrenergic receptor activation, leading to fibro-osseous reprogramming; blocking this signaling in a rodent model prevented the development of keloid-like pathology.
9 citations
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June 2009 in “Cell Proliferation” This study found that Cream 1 effectively prevented UV radiation-induced nerve ending damage in human skin samples, unlike placebo and SPF15 creams.
260 citations
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January 2020 in “Nature” Stress can cause hair to turn gray by depleting stem cells.
7 citations
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January 2017 in “Biological & Pharmaceutical Bulletin” This study found that polyacetylene compounds in Panax ginseng extracts may inhibit neurotrophin receptor binding, suggesting potential therapeutic benefits for alopecia and other hair growth disorders.
December 2023 in “Frontiers in pharmacology” In this study, intrathecal progesterone administration initially worsened mechanical allodynia in mice after nerve injury, but later reduced pain when applied during the maintenance phase, highlighting distinct roles for cytochrome P450c17 and 5α-reductase in neuropathic pain modulation.