June 2026 in “Frontiers in Cell and Developmental Biology” In this review, researchers examined how needle gauge and length impact the viability of human stem cells during injections, emphasizing the balance between minimizing tissue trauma and preserving cell viability to optimize clinical protocols.
January 2021 in “Advanced Biomedical Engineering” This study found that hair implant needles with longer point lengths and smaller bevel angles required less total work for insertion, which corresponded with surgeons' perceptions of insertion force differences.
June 2020 in “Applied sciences” This study introduced a semi-automatic hair follicle implanter that can reduce surgery time and fatigue for both patients and surgeons, with effectiveness demonstrated in animal and clinical trials.
August 2019 in “Journal of The American Academy of Dermatology” This article discusses the premade slit method in hair restoration surgery, emphasizing the importance of a tailored depth control instrument for optimal follicle implantation, but provides no new clinical results.
9 citations
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August 2014 in “The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology” This case study found that pharmacopuncture and needle-embedding therapy improved hair loss and physical condition in a woman with androgenetic alopecia, but further clinical studies are needed.
July 2026 in “Vestnik dermatologii i venerologii” Among women with androgenetic alopecia, this study observed that using Jet Peel™ with JetCare® serum led to significant trichoscopic changes, high satisfaction, and good safety after five weeks, suggesting it as a viable additional treatment option.
July 2026 in “European Journal of Plastic Surgery” This study found that combining needle-free intradermal minoxidil delivery with standard topical minoxidil therapy improved early hair growth parameters and satisfaction in women with early-stage female pattern hair loss compared to topical therapy alone, with no serious adverse events reported over the 10-week period.
February 2026 in “Humanities & Social Sciences Reviews” This study reviewed existing literature on mesotherapy as a treatment for androgenetic alopecia, finding that it may improve hair density and thickness with generally mild side effects, but emphasized variability in study designs limits the strength of these conclusions.
August 2025 in “Journal of Medical and Biological Engineering” In this study, a needle-free supersonic atomizer delivering Bacopa monnieri extract with hyaluronan was found to enhance hair growth in mice more effectively than the traditional smear method and minoxidil.
January 2014 in “The Journal of Korean Medicine Ophthalmology&Otorhinolaryngology&Dermatology” In this study, a woman's hair loss and physical condition reportedly improved with pharmacopuncture and needle-embedding therapy, but further research is suggested to validate these findings.
4 citations
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December 2022 in “Infection and Drug Resistance” In this study, four cases of neck carbuncle were treated, revealing that fire needle therapy combined with topical drugs offers less trauma, smaller scars, and faster recovery compared to surgery in early stages, but surgical debridement is essential for more advanced cases.
3 citations
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May 2011 in “International Journal of Dermatology” In this study, using a 16G epidural needle for preparing the recipient area in hair implantation minimized grafts popping out and resulted in a natural-looking hairline with satisfactory graft survival.
2 citations
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November 2020 in “Scientific Reports” This study reported that metallic-glass-coated tattoo needles reduced trauma and improved tattoo quality in pig skin experiments compared to uncoated needles.
1 citations
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May 2013 in “Polymer-korea” This study found that using dissolving micro-needles with minoxidil promoted more hair growth in an animal model compared to minoxidil treatment alone or no treatment.
January 2026 in “MEDS Clinical Medicine” This review discusses the combined use of plum-blossom and Daoma needle therapy for androgenic alopecia, emphasizing its potential benefits and the need for further clinical research, but reports no new results.
September 2025 in “Journal of Cosmetic Dermatology” Single-needle radiofrequency is effective and safe for treating facial sebaceous hyperplasia.
January 2024 in “Dermatologic therapy” This study reported that fire needle therapy improved skin lesions, increased melanocyte numbers, and boosted melanin levels in a vitiligo mouse model by upregulating the Wnt/β-catenin signalling pathway, suggesting its potential role in treating vitiligo through promoting pigmentation.
January 2024 in “Journal of Cutaneous and Aesthetic Surgery” This study describes a method to safely guard needles used in comedone extraction and scalp procedures during hair transplantation, aiming to prevent deep injuries and reduce patient fear.
August 2023 in “Journal of Chromatographic Science” This study developed a reliable UHPLC-MS/MS method to measure flavonoids from Pinus massoniana needles in rat plasma for pharmacokinetics, aiding further research on their potential use in external preparations to prevent hair loss.
November 2025 in “Journal of Multidisciplinary Healthcare” This study found that combining fire needle therapy with DHT treatment over eight weeks improved lesion severity, scar symptoms, quality of life, and reduced serum inflammatory cytokine levels in patients with moderate-to-severe acne vulgaris compared to using DHT alone.
January 2025 in “中医药研究与应用(Research and application of traditional Chinese medicine)” In this study involving acne patients, researchers compared the effects of combined fire needle and salicylic acid therapy with conventional treatment, measuring improvements in skin lesion severity, skin barrier function, and microbiota diversity; results are not reported in the abstract.
January 2024 in “Diagnostic cytopathology” In this case report, the authors observed that understanding the cytological features of trichilemmal carcinoma is crucial for accurate FNAC diagnosis of its metastases in head and neck regions.
May 2022 in “Journal of clinical and nursing research” This review article found that fire needle acupuncture has shown promise in treating alopecia areata by acting directly on skin lesions and regulating Qi and blood, aiming to offer diagnostic and treatment insights for managing the condition.
This study reviewed evidence suggesting that fire needle therapy may be a potential treatment for alopecia areata; however, it concluded that more evidence-based trials are needed to confirm its efficacy and safety.
September 2021 in “Farmacja Polska” In this summary of needle mesotherapy's role in treating alopecia, the researchers highlight its use in delivering beneficial substances directly to the skin or hair follicles, showing hair loss reduction after one treatment and hair regrowth after several sessions, although contraindications exist for certain populations.
January 2018 in “Institutional Repository of Utenos kolegija Higher Education Institution” This study observed that a course of micro needle mesotherapy improved hair and scalp condition in males with alopecia.
July 2003 in “Hair transplant forum international” This article discusses needle-stick injury risks in hair restoration practices and reports no new research findings; the authors emphasize the potential for disease transmission and safety concerns.
4 citations
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May 2020 in “Annals of palliative medicine” In this clinical study, plum blossom needle acupuncture and qi-invigorating therapy were reported to be more effective than conventional Western medicine for treating seborrheic alopecia, as they improved hormone levels, reduced hair loss, and stimulated hair growth among the 87 patients observed.
In this study, researchers aim to evaluate the effectiveness and safety of combining plum-blossom needle tapping with ginger juice rubbing to prevent hair loss in obese women after metabolic bariatric surgery, through a randomized controlled trial involving 96 participants.
January 2026 in “Dermatologic Therapy” This study found that Pinus massoniana needles extract may promote hair regrowth in a mouse model of androgenetic alopecia, potentially by reducing oxidative stress and affecting immune, metabolic, and apoptosis-related pathways.