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The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.

PGD2 stops hair growth and is higher in bald men with AGA.

Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.

Different types of skin cells have unique genetic markers that affect how likely they are to spread cancer.

Wnt signaling controls whether hair follicle stem cells stay inactive or regenerate hair.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

Male hormones, particularly DHT, are linked to male pattern hair loss, and treatments like finasteride can help, but they don't work for postmenopausal women's hair loss, which may have different causes.

Stem cell niches support, regulate, and coordinate stem cell functions.

Chemotherapy-induced hair loss significantly affects patients' well-being, and nurses are key in helping them cope, but more research is needed to find effective treatments.

TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Laser hair removal effectiveness depends on targeting hair structures without harming the skin, and improvements require more research and expert collaboration.

Different types of stem cells with unique roles exist in blood, skin, and intestines, and this variety is important for tissue repair.

Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.

Different types of stem cells and their environments are key to skin repair and maintenance.

Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.

The document concludes that specific cells are essential for hair growth and more research is needed to understand how to maintain their hair-inducing properties.

Nanoparticles can improve skin drug delivery but have challenges like toxicity and stability that need more research.

Damage to skin releases dsRNA, which activates TLR3 and helps in skin and hair follicle regeneration.

Oxidative stress contributes to hair graying and loss as we age.

Stem cell plasticity is crucial for wound healing but can also contribute to cancer development.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

The telogen phase of hair growth is active and important for preparing hair follicles for regeneration, not just a resting stage.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.

Hair grows faster in the morning and is more vulnerable to damage from radiation due to the internal clock in hair follicle cells.

Tiny particles from stem cells help activate hair growth cells and encourage hair growth in mice without being toxic.

Minoxidil and finasteride can slow hair loss and stimulate regrowth, but won't restore all lost hair or reverse complete baldness.

Hair, teeth, and mammary glands develop similarly at first but use different genes later.

The document concludes that proper diagnosis and a combination of medical, hair-care, and surgical treatments are important for managing alopecia in black women.