June 2023 in “jurnal veteriner” In this study, Typhonium flagelliforme leaf-ethanolic extract combined with natural interferon was observed to stabilize body weight, inhibit tumor growth, and reduce mitosis, angiogenesis, and certain protein expressions in carcinogen-induced tumors in female mice, suggesting potential antitumor effects.
91 citations
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January 2010 in “Journal of Allergy and Clinical Immunology” This review explores the emerging roles of NK cells in various diseases, including allergies and skin conditions, and reports no new clinical results while indicating NK cell involvement in immune processes.
3 citations
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January 2023 in “JEADV Clinical Practice” This study suggests that IL-17 may play a more significant role than IFN-γ in the pathogenesis of chronic alopecia areata, with increasing severity linked to Th17 lymphocytes and cytotoxic T lymphocyte infiltration.
April 2023 in “Journal of Investigative Dermatology” This research explored the roles of various T cell types in chronic alopecia areata, finding that increased severity of lesions and hair loss may be linked to decreased lesional Foxp3+ Tregs, with a notable role for IL-17 and Th17 lymphocytes in the pathological process.
January 2016 in “Springer eBooks” New materials and methods could improve skin healing and reduce scarring.
125 citations
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August 2020 in “Frontiers in Immunology” This review discusses sex-based differences in immune responses, focusing on genetic, hormonal, and microbiome factors influencing infections like COVID-19, and reports no clinical results.
191 citations
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May 2018 in “British journal of dermatology/British journal of dermatology, Supplement” This study reviewed recent theories on alopecia areata's pathogenesis, highlighting its autoimmune nature due to immune privilege disruption in hair follicles, and noted current treatments have limited efficacy with high relapse rates, underscoring the need for further research into its mechanisms for better therapies.
134 citations
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July 2020 in “Experimental dermatology” This review discusses immune privilege in anagen hair follicles and its collapse in alopecia areata, emphasizing the importance of restoring this function for effective management and disease relapse prevention.
4 citations
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March 2018 in “Daehan han'yi hag'hoeji/Journal of Korean medicine” This study found that topical application of Astragalus membranaceus extract induced hair regrowth and reduced immune response markers in mice with natural hair loss.
June 2025 in “Academic Medical Journal” This review discusses the mechanisms underlying the collapse of hair follicle immune privilege in alopecia areata and emphasizes the importance of therapeutic strategies aimed at restoring immune tolerance.
November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, researchers found that ex vivo and in vivo administration of the TYK2 inhibitor BMS-986202 prevented immune privilege collapse and promoted hair regrowth in models of alopecia areata, suggesting this approach may offer a new therapeutic avenue deserving of clinical investigation.
June 2023 in “Research Square (Research Square)” This study identified shared gene expression changes and immune cell infiltration patterns that may contribute to hair loss in alopecia areata and cutaneous lupus erythematosus, but also highlighted factors that might preserve hair in psoriasis patients.
April 2021 in “Sohag Medical Journal” This review outlines the proposed theories behind the development of alopecia areata, emphasizing the autoimmune process involving lost immune privilege in hair follicles, and stresses the need to pinpoint specific pathogenic mechanisms for potential treatments.
34 citations
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August 2002 in “British Journal of Dermatology” This study observed that two patients treated with interferon α-2b and ribavirin for chronic hepatitis C experienced complete and reversible straightening of their natural curly hair, which recurred with treatment resumption.
13 citations
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October 2019 in “Journal of lasers in medical sciences” This study found that the cytokine-mediated signaling pathway is the primary pathway disrupted in skin after CO2 laser surgery.
1 citations
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May 2004 in “Journal der Deutschen Dermatologischen Gesellschaft” This article from the 4th Intercontinental Meeting of Hair Research Societies provides no abstract or new findings.
In this case report, interferon-alpha treatment for a man with hemophilia and hepatitis C was associated with unexpected diffuse hair growth, likely caused by the medication.
May 2026 in “International Journal of Versatile Research and Analysis” This study used air wedge interferometry to measure the thickness of human scalp hair from three individuals, finding average thicknesses of 66.482 µm, 59.355 µm, and 59.927 µm respectively, within the typical range for adults.
107 citations
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December 2003 in “Dermatologic Therapy” This paper reviews the use of interferons, particularly alfa interferon, in treating cutaneous T-cell lymphoma, noting its substantial efficacy both alone and in combination therapies with predictable, generally well-tolerated side effects.
3 citations
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June 2021 in “Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512)” This review highlights phytochemicals, particularly flavonoids and phenolics, as potential supportive treatments for SARS-CoV-2 by interfering with viral proteins and providing anti-inflammatory effects; it suggests a foundation for future therapeutic and vaccine development efforts.
September 2024 in “Journal of the Pakistan Medical Association” In this experimental study, laser irradiation significantly altered the gene expression of cytokines in cultured human T-cell lymphocytes, suggesting that such laser light may photobiomodulate cytokine production in vitro.
January 2019 in “Journal of cosmetology & trichology” In this study, researchers found that supplementation with L-cystine, either alone or with a keratin hydrolysate, significantly improved hair density, hair and nail brightness, and nail growth in women experiencing acute telogen effluvium and brittle nail syndrome over three months.
44 citations
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March 2016 in “Frontiers in cellular neuroscience” In this study using zebrafish, four bisbenzylisoquinoline derivatives were found to protect hair cells from aminoglycoside-induced damage without reducing antibiotic efficacy, potentially leading to therapies for patients undergoing such treatments.
36 citations
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May 2021 in “Nutrients” This review summarizes current knowledge on the efficacy of natural molecule supplementation, such as inositols and omega-3 fatty acids, in managing PCOS symptoms but reports no new clinical results.
28 citations
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January 2000 in “Medical Mycology” This article reviews the impact of natural fungal pathogens on laboratory animal research and reports no new results, calling attention to infection risks with dermatophytes, Candida, and pneumonia in immunocompromised rodents.
July 2021 in “International Journal of Research in Ayurveda and Pharmacy” This review discusses the potential of plant-synthesized secondary metabolites as natural therapeutics for COVID-19 and reports no new clinical results.
52 citations
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March 2010 in “British Journal of Dermatology” This study demonstrated the expression of type 1 interferon-related proteins in inflammatory lesions of alopecia areata, showing a distinct distribution pattern compared to cicatricial alopecia.
32 citations
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December 2018 in “Cytokine” This review discusses the involvement of type I interferons in skin autoimmune and inflammatory diseases but reports no new clinical results.
22 citations
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April 1998 in “Dermatologic Clinics” This article reviews the therapeutic use of interferons and other cytokines in various viral, tumorous, and inflammatory diseases, discussing their biological effects and potential future applications without presenting new experimental results.
34 citations
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April 2008 in “Journal of the European Academy of Dermatology and Venereology” This study reported that while lichen planus was not significantly linked to hepatitis C virus infection, pruritus, dry skin, and hair loss were more common in HCV patients post-interferon treatment.