6 citations
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June 2018 in “Journal of Stomatology, Oral and Maxillofacial Surgery” In this cadaveric study, lipofilling was found easier to perform on the face than the scalp, whereas nanofat grafting was particularly suited for precise injections in scalp areas, suggesting a combination of techniques could aid in treating alopecia.
3 citations
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October 2023 in “Plastic & Reconstructive Surgery Global Open” This study suggests that waiting for scarred tissue to mature and preparing the recipient area with nanofat can lead to better outcomes for hair transplantation in patients with eyebrow loss due to deep facial burns.
62 citations
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October 2017 in “JAMA facial plastic surgery” This study reported that using condensed nanofat combined with fat grafts significantly improved the aesthetic and functional aspects of atrophic facial scars in 20 patients, as assessed by both patients and plastic surgeons using the Patient and Observer Scar Assessment Scale.
1 citations
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November 2024 in “Journal of Cutaneous and Aesthetic Surgery” This study highlights fat grafting and nanofat as promising options for treating dark circles, offering benefits in improving both volume and skin quality through a single-stage procedure with long-lasting outcomes.
3 citations
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July 2023 in “Plastic and reconstructive surgery/PSEF CD journals” This systematic review found that sole nanofat grafting in plastic and reconstructive surgery shows potential benefits for scar improvement and anti-aging, with increases in skin thickness, collagen, and elastic fibers, but the evidence level remains low and further research is needed.
January 2025 in “Zagazig University Medical Journal” This study found that nanofat injection before hair transplant may improve the survival of hair grafts in patients with secondary cicatricial alopecia.
September 2018 in “Plastic and reconstructive surgery. Global open” This study found that using conchal cartilage grafts to reinforce split earlobe repairs provided satisfactory aesthetic and functional outcomes, with no recurrence of tears over a 4-year follow-up.
60 citations
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June 2019 in “Ageing Research Reviews” This review discusses the potential of adipose-derived tissue components like nanofat and stem cells for aesthetic rejuvenation, covering their use in hair growth, scar reduction, and more, without reporting new clinical results.
2 citations
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March 2019 in “Plastic and Reconstructive Surgery” This review discusses various mechanical isolation procedures for tissue-like stromal vascular fraction, such as the nanofat procedure, and highlights the need for controlled trials to assess their regenerative effectiveness.
March 2024 in “Cosmetics” This review outlines the principles of regenerative medicine as applied to cosmetic dermatology, highlighting the need for more data and in vivo trials to standardize methods in this emerging field, while also suggesting future research directions.
October 2023 in “Facial Plastic Surgery” This article describes the PHAT technique for lip and facial rejuvenation but reports no new clinical findings; the technique aims to improve skin quality and enhance surgical outcomes.
January 2022 in “Aesthetic surgery journal” This study found that injections of extracellular vesicles derived from mesenchymal stem cells improved hair growth in over 50% of female and nearly 80% of male patients after six months.
2 citations
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April 2025 in “Cells” This study found that heat preconditioning of nanofat from mice did not improve tissue vascularization or integration in grafting, and actually reduced vascularization due to increased expression of anti-angiogenic factors, suggesting it is not beneficial for enhancing its vascularization properties.
September 2018 in “Plastic and Reconstructive Surgery – Global Open” This study observed that gluteal augmentation via liposuction and fat grafting in 200 female patients achieved a desirable waist-hip ratio of around 0.7, reporting lower morbidity and lasting results, with patient satisfaction measured through questionnaires and photographs.
June 2022 in “Al-Azhar International Medical Journal /Al-Azhar International Medical Journal” This study found that autologous emulsified fat followed by hair transplantation using FUE was more effective than FUE alone in improving outcomes for patients with cicatricial alopecia after six months.
November 2023 in “Journal of cosmetic dermatology” This review article evaluates the effectiveness of autologous fat transplantation in regenerative medicine and rejuvenation, highlighting its biocompatibility and non-immunogenic properties as a facial filler, and notes the variable outcomes based on adipose tissue size.
1 citations
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September 2018 in “Plastic and reconstructive surgery. Global open” This study found that a single session of nanofat combined with platelet-rich plasma significantly increased hair density and thickness in male androgenic alopecia patients compared to platelet-rich plasma alone, with effects partially persisting at 12 months.
2 citations
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September 2017 in “Plastic and reconstructive surgery. Global open” This pilot study found that a single session of nanofat treatment may increase hair thickness and density in male patients with androgenic alopecia, with effects lasting up to 12 months in some cases, though results varied.
4 citations
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September 2020 in “Annals of Translational Medicine” This study found that concentrated nanofat, used alone or with decellularized nanofat, may enhance hair growth in mice by activating dermal papilla cells and the anagen phase.
September 2018 in “Plastic and Reconstructive Surgery – Global Open” This study found that real-time ultrasound-assisted gluteal fat grafting effectively allowed surgeons to verify subcutaneous fat injection, potentially reducing risks of major complications, though it involved increased costs, surgical time, and a learning curve.
28 citations
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January 2023 in “Cell Transplantation” This study found that the Hy-Tissue Nanofat product isolates a significant number of proliferative nucleated cells and shows potential for regenerative medicine due to its rich content of adipose-derived stem cells and pluripotent MUSE cells.
Nanofat injection is safe and effective for improving skin texture and patient satisfaction.
8 citations
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June 2023 in “Journal of clinical medicine” This study reviews the use of nanofat in facial rejuvenation and cosmetic surgery, highlighting its potential for improving skin appearance and treating conditions like wrinkles and acne scars, yet emphasizes the need for further research into its long-term efficacy and safety.
This study found that hypoxic preconditioning of nanofat from donor mice reduced its vascularization capacity in vivo, suggesting that this approach cannot currently enhance nanofat's regenerative potential.
36 citations
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July 2022 in “Stem Cell Research & Therapy” This study concluded that using adipose tissue-derived stromal vascular fraction significantly improved acne scars by increasing collagen content and skin thickness compared to nanofat alone.
7 citations
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June 2024 in “Skin Research and Technology” Combining treatments significantly reduces dark circles and wrinkles better than nanofat alone.
July 2019 in “Facial Plastic Surgery Clinics of North America” New techniques and technologies are improving facial plastic and reconstructive surgery.
43 citations
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June 2016 in “Clinics in Plastic Surgery” This article reviews technical aspects of using autologous fat transfer for facial rejuvenation and examines existing evidence for stem cell and platelet-rich plasma therapies in aesthetic practice, reporting no new results.
July 2024 in “Frontiers in Bioengineering and Biotechnology” In this mouse study, the researchers found that cryopreserving nanofat at -20°C maintained its viability and regenerative potential, comparable to freshly generated nanofat, supporting its potential for repeated use in regenerative applications.
October 2025 in “International Journal of Medical Science and Clinical Research Studies” In this systematic review, the researchers provide an overview of recent techniques and innovations in the surgical reconstruction of traumatic scalp injuries, highlighting various methods and factors influencing the choice of reconstructive strategy to improve patient outcomes.