This chapter reviews nanocarriers for acne therapy, highlighting their ability to reduce lesions and inflammation while improving the safety and effectiveness of treatment, though no new clinical results are reported.
January 2018 in “Refubium (Universitätsbibliothek der Freien Universität Berlin)” In this study, researchers tested various nanocarrier characteristics and found they could enhance drug delivery to specific skin areas and immune cells, potentially improving treatments for skin conditions by targeting drugs effectively.
January 2016 in “Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver” This study found that novel biodegradable nanocarriers with highly hydrophobic cores significantly increased the solubility and sustained release of hydrophobic drugs and dyes, showing promise for drug delivery applications.
January 2015 in “Elsevier eBooks” This chapter reviews the use of liposomes and cyclodextrins to improve the delivery and effectiveness of the peptide angiotensin-(1-7) in various therapeutic applications and reports no new experimental results.
January 2015 in “SciDok (Saarland University and State Library)” This study confirmed the porcine ear skin model's effectiveness for studying nanoparticle-based drug delivery in human hair follicles, noting particle-dependent uptake and enhancement by massage.
4 citations
,
January 2020 in “Elsevier eBooks” This review discusses the protective and reparative properties of chitin nanofibrils on hair structure and reports no clinical results; the authors suggest chitin-based products may aid in hair regrowth.
2 citations
,
September 2016 in “Journal of Dermatological Science” This study reported that squarticles, nanoparticle carriers made from sebum-derived lipids, significantly enhanced minoxidil delivery to hair follicles in vitro, increasing follicular uptake sevenfold and minimizing systemic absorption compared to a free control solution, while showing good skin tolerability.
21 citations
,
July 2017 in “Journal of Cosmetic and Laser Therapy” This review discusses the research and development of vesicular carriers to enhance the delivery and effectiveness of active ingredients in cosmetic products, reporting no new clinical results.
June 2026 in “Discover Nano” This review discusses current treatment strategies for alopecia and highlights the potential of lipid-based nanoparticles to improve drug delivery to the scalp and hair follicles, noting their ability to enhance skin penetration and drug stability while outlining associated challenges and the need for further research.
54 citations
,
June 2020 in “Pharmaceutics” This review discusses the advancements in using "soft" colloidal nanocarriers for delivering photosensitive agents and highlights their potential applications in treating diseases like cancer, but it reports no new clinical results.
February 2024 in “International journal of pharmaceutical sciences and nanotechnology” In this article, researchers explored the potential of lipidic nanocarriers to enhance the delivery and effectiveness of finasteride in a topical gel form for androgenic alopecia, aiming to improve treatment options and reduce systemic adverse effects.
This study found that finasteride-loaded nanostructured lipid carriers developed for topical application showed satisfactory size, stability, and prolonged drug release, suggesting potential for enhanced delivery in androgenic alopecia treatment.
52 citations
,
January 2020 in “Scientific Reports” This study found that nanostructured lipid carriers with clobetasol propionate significantly enhance follicular drug delivery compared to commercial cream, and manual massage further doubles follicular retention.
14 citations
,
February 2025 in “Pharmaceutics” This review highlights recent advancements in using niosomes as nanocarriers for improved delivery and sustained release of active cosmetic compounds, discussing their properties, applications, and future potential in cosmetic chemistry.
3 citations
,
May 2014 in “PubMed” This study used a newly developed RP-HPLC method to accurately measure finasteride distribution in human cadaver skin after applying different vesicular drug delivery systems.
20 citations
,
August 2023 in “Saudi Pharmaceutical Journal” This study found that cetirizine-loaded niosomal gels demonstrated superior skin deposition and retention compared to plain cetirizine gel, suggesting potential for improved topical management of alopecia.
9 citations
,
October 2013 in “Drug Delivery” This research found that ethosomes significantly enhanced finasteride delivery into the dermis of human cadaver skin compared to liposomes in an in vitro study.
8 citations
,
May 2024 in “Advanced NanoBiomed Research” This review examines advancements in lipid and inorganic nanocarriers, such as liposomes and inorganic nanoparticles, for transdermal drug delivery, noting enhanced absorption and stability but acknowledging that few have reached clinical use.
July 2026 in “Pharmacological Research - Modern Chinese Medicine” In this study, researchers developed and optimized a smartlipid nanocarrier gel formulation of berberine that significantly reduced hair loss and promoted faster hair regrowth in a testosterone-induced hair loss model, showing potential as an effective treatment for androgenetic alopecia.
5 citations
,
December 2023 in “Materials” This review paper highlights the development and application of organic and biogenic nanocarriers for delivering bioactives, focusing on eco-friendly and sustainable nanotechnology strategies while addressing challenges like toxicity and paving the way for future innovations in green solution approaches.
July 2024 in “ADMET & DMPK” This review discusses the potential for surface-modified nanostructured lipid carriers to enhance hair regrowth by improving drug absorption and stability, focusing on their use with agents like minoxidil and finasteride for hair loss treatment.
49 citations
,
February 2025 in “Science Advances” This review discusses the potential of biomimetic synthetic vesicles to advance precision diagnostics and medicine by combining the beneficial properties of naturally occurring extracellular vesicles and synthetic nanoparticles, although no new clinical results are reported.
28 citations
,
November 2020 in “Journal of Controlled Release” In this study, microneedles combined with finasteride nanostructured lipid carriers (FIN-NLC-MNs) were found to enhance skin penetration and specifically target hair follicles, promoting hair growth and gene regulation in androgenetic alopecia.
7 citations
,
May 2016 in “European Polymer Journal” This study found that biodegradable hyperbranched polyesters improved the solubility and loading capacity of hydrophobic drugs, with complete pyrene release achieved in 16 days under enzymatic conditions.
159 citations
,
July 2014 in “Molecular pharmaceutics” This study found that MPEG-dihexPLA micelles significantly improved the skin deposition of tacrolimus compared to a marketed ointment, suggesting better targeted delivery with reduced systemic absorption.
59 citations
,
January 2015 in “Nanoscale” In this study, polymeric micelles containing retinoic acid were found to improve targeted delivery to hair follicle structures in human skin more efficiently than a marketed retinoic acid gel, suggesting potentially safer and more effective acne treatment.
50 citations
,
December 2017 in “Nanoscale” This study found that polymeric micelle formulations significantly improved the targeted delivery of adapalene to hair follicles compared to standard Differin® products, which suggests potential advantages in treating hair follicle-related conditions and reducing side effects.
2 citations
,
September 2024 in “Asian Journal of Pharmaceutics” This research discusses advancements in niosomal drug delivery systems, highlighting their promising potential to improve targeted drug delivery due to their ability to encapsulate various drug types efficiently, offering advantages over traditional liposome systems in terms of chemical stability and therapeutic efficacy.
1 citations
,
July 2021 in “Current nanomedicine” This study found that nanostructured lipid carriers could serve as a promising vehicle for topical Acitretin delivery in psoriasis treatment, potentially reducing oral side effects and enhancing patient compliance.
February 2026 in “Journal of drug targeting” This study found that combining laser ablation with nanoparticulate drug formulations effectively enhanced the skin and follicular delivery of hydrophilic drugs like minoxidil and minocycline in preclinical models.