January 2012 in “Yearbook of Dermatology and Dermatologic Surgery” Alopecia areata is a hair loss condition that often starts before age 30 and can affect various body parts, with unpredictable hair regrowth chances.
This study found that activating BMP signaling in rodent and primate models significantly promotes nail and digit regeneration after amputation by enhancing the role of specific nail stem cells, though extreme proximal amputation only permitted partial regeneration without bone reconstruction.
January 2024 in “Case Reports in Dermatological Medicine” In this case report, a patient with alopecia areata-associated nail changes experienced normalization of nail appearance and texture after 11 months of treatment with baricitinib, suggesting that the drug may be an effective option for similar cases, although further research is needed.
This article reviews management strategies for nonscarring and scarring alopecias, noting insufficient evidence-based guidelines for scarring types due to their rarity.
July 2017 in “British Journal of Dermatology” The document concludes that scalp conditions have various causes and can present in many different ways.
1 citations
,
June 2022 in “PubMed” This article reviews the evaluation and management of scarring and nonscarring alopecias, emphasizing the importance of early treatment to prevent permanent hair loss in scarring forms, but reports no new clinical results.
March 2026 in “Communications Biology” This study identified nine compounds that activate Wnt signaling, with aminoacridine and proflavine especially promoting hair and nail regeneration in mouse models, highlighting new therapeutic candidates from existing FDA-approved and natural compounds.
2 citations
,
December 2023 in “Journal of clinical immunology” This study describes the positive effects of the JAK inhibitor ruxolitinib in treating autoimmune manifestations in three patients with autoimmune polyendocrine syndrome type-1 over a period of at least 30 months, with excellent tolerance and no adverse events observed.
87 citations
,
December 2016 in “British journal of dermatology/British journal of dermatology, Supplement” This study describes and characterizes four cases of alopecia areata induced by immune checkpoint inhibitor therapy in cancer patients, highlighting the importance of recognizing and managing these hair-related adverse events.
79 citations
,
April 1996 in “JAMA” This article describes a case of selenium poisoning in a 36-year-old man who experienced hair loss, nail changes, and paresthesias after taking selenium-containing vitamin tablets.
48 citations
,
May 1999 in “International Journal of Dermatology” This article reviews the diagnosis and management of alopecia areata but reports no new research findings.
35 citations
,
January 2013 in “Indian Journal of Dermatology, Venereology and Leprology” This study found that intralesional triamcinolone acetonide is effective for treating localized patchy alopecia areata, with dermoscopy aiding in early detection of clinical response and adverse effects.
September 2025 in “Clinical Toxicology” In this investigation, acute alopecia was linked to selenium-contaminated wheat in rural Maharashtra, India, following reports of sudden hair loss in 18 villages, with evaluations conducted in Machindrakhed and Bhondgaon.
February 2025 in “Gastroenterology” Corticosteroids improved symptoms in a man with Cronkhite-Canada Syndrome.
September 2022 in “Intisasi sains media” This case report describes a 22-month-old with alopecia universalis who showed improved hair growth after receiving combination therapy with minoxidil, corticosteroids, and excimer laser.
September 2017 in “Pediatric Dermatology” No results are reported in this correspondence published in Pediatric Dermatology, as it responds to prior communication about contact dermatitis related to alopecia and hyperpigmentation.
January 2003 in “Steinkopff eBooks” This review discusses the incidence, demographics, and associated conditions of alopecia areata and provides no new clinical findings.
June 1997 in “Australasian Journal of Dermatology” This article discusses hair and nail research contributions in dermatology but reports no new clinical findings.
9 citations
,
January 2020 in “Postepy Dermatologii I Alergologii” This review discusses the enigmatic nature of frontal fibrosing alopecia and reports no clinical results; the authors stress the need for further research.
2 citations
,
January 2019 in “Elsevier eBooks” This review discusses biotin's role in nutrition and suggests no benefit to supplementing it for hair, nails, and skin in healthy individuals; it reports preliminary findings that high dosages may help some multiple sclerosis patients.
March 2023 in “International journal of trichology” This review discusses genetic conditions linked to complete scalp alopecia in children, identifying six genetic causes, but reports no new clinical results.
2 citations
,
November 1955 in “Archives of dermatology” In this report of a pediatric alopecia case, cortisone and ACTH gel treatments did not result in significant nail improvement, but there was considerable scalp hair regrowth.
January 2025 in “International Journal of Dermatology” In this case report, a 14-year-old male with alopecia areata subtotalis and nail involvement showed significant improvement after 9 months of treatment with oral tofacitinib, including complete hair regrowth and nail texture improvement, though further studies are needed to confirm these findings.
May 2018 in “European Journal of Dermatology” Adjusting the medication tacrolimus resolved a boy's red nail beds after a stem cell transplant.
8 citations
,
September 2016 in “Journal of Investigative Dermatology” In this study, Flii overexpression in mice enhanced fingertip regeneration and nail formation after both distal and proximal amputations, suggesting a role in digit and hair follicle regeneration possibly involving Wnt signaling.
In this case series, Xiang Chen reported instances of nail damage and hair loss following herpes zoster, noting the need for further exploration into the mechanisms and potential risk factors such as tuberculosis infection and kidney transplantation.
4 citations
,
November 2009 in “Medical Clinics of North America” This article discusses how changes in hair and nails may indicate systemic diseases, but it provides no new results; the authors emphasize their usefulness in clinical diagnosis.
33 citations
,
April 1990 in “Dermatologic Clinics” Minoxidil effectively treats hair loss, with better results in women.
4 citations
,
March 2025 in “Pediatric Dermatology” This review examines the clinical presentation of alopecia areata in children and compares it to adult-onset cases, noting that data on pediatric cases is scarce and often varies, with reported onset typically between ages 6 and 12.
This review outlines the applications of intralesional steroid therapy, particularly triamcinolone acetonide, in several dermatological conditions and suggests further trials for certain uses but reports no new clinical findings.