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The conclusion is that using drugs to block the TOR pathway might slow aging and prevent age-related diseases.

Air pollution worsens skin diseases and aging by causing inflammation and oxidative stress.

Chemicals and body size might change when puberty starts and progresses, but more research is needed to confirm this.

Treatments that reduce oxidative stress and fix mitochondrial problems may help heal chronic wounds.

Removing part of the vitamin D receptor stops vitamin D from working properly.

Chemotherapy can cause various skin reactions, with hair loss being the most common, and proper diagnosis and treatment of these reactions are important.

Women with PCOS often have more belly fat and higher insulin levels, but belly fat isn't the only cause of their insulin resistance.

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

Wnt1/βcatenin signaling is crucial for heart repair after injury.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.

Blocking the enzyme 5α-reductase can shrink the prostate and help treat enlarged prostate issues.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Stem cells are crucial for skin repair and new treatments for chronic wounds.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Telogen effluvium is a reversible hair loss condition that requires a detailed diagnosis and often resolves on its own.

The document provides a method to classify human hair growth stages using a model with human scalp on mice, aiming to standardize hair research.

Minoxidil and finasteride treat hair loss in men, while minoxidil treats hair loss in women.

Finasteride effectively treats BPH, but needs more trials to understand potential.

Hair color production in mice is closely linked to the hair growth phase and may also influence hair growth itself.

Interferon alfa-2a is effective for treating cutaneous T cell lymphoma but has significant side effects.

PGD2 stops hair growth and is higher in bald men with AGA.

Lactate production is important for activating hair growth stem cells.

High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.

The hedgehog signaling pathway is crucial for hair growth but not for the initial creation of hair follicles.

Fungi-produced compounds can change plant root growth.

Researchers found 19 genes important for root hair growth in a plant called Arabidopsis.