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This study observed that cutaneous microwounds created by fractional photothermolysis heal differently from typical wounds, displaying rapid re-epithelialization and limited inflammation, which may help reduce scar formation by delaying collagen remodeling and minimizing myofibroblast activation.

This study found that fibromodulin significantly reduces scar formation and boosts scar strength in rodent and porcine models, suggesting potential for FMOD-based therapies in cutaneous wound repair.

This study found that epidermal stem cell-specific Jag1 expression levels are crucial for effective wound healing and scar reduction, and porcine acellular dermal matrix treatment enhances this process in mice by boosting Notch/Jagged1 signaling.

This study found that implanting hair-follicle-associated pluripotent stem cell sheets in mice significantly accelerated wound closure and reduced scar formation compared to non-implanted controls.

This study in mice found that fractional photothermolysis can improve dermal scar formation by promoting slow, organized collagen regeneration with minimal myofibroblast activation.

This study investigated dermal fibroblasts in mouse skin using single-cell RNA sequencing and identified signaling pathways that influence adipogenesis, finding that IL-1-NF-κB promotes, while WNT-β-catenin inhibits, the adipogenic potential of these cells, with implications for wound healing and scar formation.

This study found that MRL/MpJ mice heal burn wounds with scar formation, experiencing delayed wound closure and impaired myofibroblast development, which contrasts with quicker contraction in BALB/c mice.

This study found that extracellular vesicles derived from mesenchymal stem cells and umbilical cord blood plasma enhanced wound healing and reduced scar formation in mice, suggesting their potential as therapeutic agents for skin repair.

Certain hairstyles can cause scalp diseases, smoking is linked to hair loss, 5% minoxidil foam is effective for hair loss treatment, and various factors influence wound healing and hair growth.

In this study, researchers used a mouse model to demonstrate that expression of MARCKSL1 in dendritic cells plays a crucial role in modulating fibrotic responses and scar formation during wound healing, suggesting that targeting this expression could offer new therapeutic strategies for scar prevention.

In this review, retinoids are highlighted as promising agents for promoting scarless skin regeneration by coordinating cellular and molecular processes that suppress fibrosis, enhance re-epithelialization, promote angiogenesis, and enable hair follicle formation, potentially advancing functional skin repair.

This review presents an overview of the integrated organ systems involved in wound healing and reports no new findings; the authors emphasize the roles of blood coagulation, immune response, and cellular mechanisms in tissue repair.

This review explores fibroblast heterogeneity in the mammalian dermis and suggests potential therapeutic applications by targeting fibroblast subtypes, but reports no new experimental results.

This narrative piece considers how epigenetic factors may influence the processes of skin wound healing, including hair follicle formation, but it presents no new experimental results.

This study found that dermal adipocytes contribute to efficient skin repair by releasing fatty acids that recruit macrophages and transforming into myofibroblasts that aid wound healing.

This study reported that Hedgehog signaling in papillary fibroblasts is crucial for hair follicle regeneration during wound healing, emphasizing its potential for developing regenerative therapies in scarring wounds.

This study found that hair follicles in mice and humans can convert wound-related myofibroblasts into adipocytes, suggesting a potential pathway to reduce scar formation by activating BMP signaling.

This review discusses dermal cell heterogeneity in wound healing and scar formation, highlighting the varied roles of different fibroblasts and the potential of skin substitutes without presenting new clinical results.

Fibroblasts are crucial in scar formation and wound healing, with potential therapies aiming for scarless healing.

This study reports that using a hydrogel-based therapy that dynamically regulates reactive oxygen species helps achieve skin regeneration in infected wounds, promoting organized dermal architecture with improved hair follicle and blood vessel formation, rather than scar formation.

This study found that in mice, dermal adipocytes initiate inflammation and aid repair after skin injury by releasing lipids, suggesting a role in managing inflammatory diseases and impaired wound healing.

This study found that applying a topical inhibitor of TGF-β1 may enhance scar maturation and improve the appearance of hypertrophic scars in a nude mouse model after two weeks.

Turning scar-forming cells into fat cells can reduce scarring.

This review updates the understanding of fibroblast heterogeneity in wound healing, discussing advancements in fibroblast roles and potential therapies, but it reports no new clinical results.

This study suggests that exosomal miRNAs from human amniotic fluid stem cells may inhibit myofibroblast differentiation and reduce fibrotic scarring in wound healing.

This review discusses recent advancements in scar reduction techniques, highlighting promising therapeutic targets and the role of Wnt/β-catenin signaling in promoting scarless wound healing, but reports no new clinical results.

This review discusses the developmental regulation of wound healing mechanisms in mammals, focusing on the role of the Wnt and TGF‐β signaling pathways, and reports no new clinical findings.

This study found that myofibroblasts can be reprogrammed to generate lipid-filled adipocytes in large skin wounds, potentially providing a new source of adipogenic progenitor cells for regeneration.

This study found that a hydrogel containing icariin enhanced wound healing and hair-follicle regeneration in vivo by promoting M2 macrophage polarization and modulating the BMP pathway, with treated skin defects showing improved recovery and new hair follicle development compared to untreated defects.

This study developed a composite hydrogel that delivered multiple proteins, enhancing skin wound healing by accelerating closure and promoting hair follicle regeneration.