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This study investigated the use of Minoxidil encapsulated in HA-PLGA nanoparticles for alopecia treatment and found that these nanoparticles efficiently delivered the drug to hair follicle cells without significant cytotoxicity, offering a potential transdermal delivery method for various diseases.

This study found that the nonionic surfactant Brij 78 stabilized cationic minoxidil microparticles against aggregation, maintaining their substantivity in the presence of excess anionic surfactant.

Chitosan-coated nanocapsules improve minoxidil delivery for better hair regrowth.

This study found that ethosome-loaded minoxidil and tocopherol acetate improved hair regeneration and regulated the microenvironment around hair follicles better than commercial minoxidil in androgenic alopecia model mice, showing promise as a treatment strategy.

This study found that Crataegi Fructus water extract may promote hair growth in mice by enhancing hair density, thickness, and length and activating the Wnt/β-catenin signaling pathway.

This study found that Chamaecyparis obtusa oil significantly increased hair growth in mice, comparable to minoxidil, based on morphological and histological observations.

The new formulation with minoxidil, chitosan, and Aloe vera improves hair growth and reduces side effects.

This study found that Saengbal-eum(Shengfa-yin) promoted hair regrowth in a mouse model similarly to 3% Minoxidil, with its effects potentially linked to EGF activity in hair roots.

This study found that neutral liposomes were most effective at delivering minoxidil into pilosebaceous units compared to other tested formulations.

This study found that only minoxidil encapsulated in cationic vesicles significantly promoted hair growth in mice, likely due to its higher retention on the skin.

This study found that minoxidil applied to a damp scalp may increase drug penetration in vitro, potentially improving treatment effectiveness.

This review critically analyzes recent literature on the use of nanotechnology in alopecia treatment, reporting promising results for improving drug delivery and hair growth, though challenges in maintaining physical stability may limit large-scale commercialization.

This study found that using monoolein cubic phase nanoparticles with an entrapped hydroxypropyl β-cyclodextrin/minoxidil complex increased minoxidil skin permeation, but minoxidil retention in the skin was higher with a traditional solution.

This study found that 3% peppermint oil significantly enhanced hair growth in C57BL/6 mice, showing increased dermal thickness, follicle number, and follicle depth compared to other treatments.

This research investigated aqueous alginate-based hydrogels for delivering minoxidil and reported that using hydroxypropyl-β-cyclodextrin (HP-β-CD) with molar substitution 0.65 significantly enhanced minoxidil's solubility and skin permeability without damaging the epidermis, suggesting potential as an alternative to commercial minoxidil solutions.

This study evaluated new aqueous gel formulations of minoxidil without irritants and found that the calcium alginate gel showed the best performance in terms of drug release and skin permeation.

This study found that lipid nanocarriers called squarticles, conjugated with an antibody, enhanced minoxidil uptake in dermal papilla cells, potentially improving alopecia treatments.

This study demonstrated that customized microneedle arrays can precisely induce targeted hair regeneration and improve hair quality in mice, potentially offering a personalized treatment approach for hair loss.

This study investigated a liposomal hydrogel system for delivering minoxidil and tretinoin to treat androgenic alopecia, finding that the system enhanced skin permeation of minoxidil while retaining tretinoin on the skin and was non-irritating in animal tests, suggesting its potential effectiveness.

This study found that KF19418 stimulated hair follicle growth in vitro and accelerated hair regrowth in a mouse alopecia model, with effects comparable to minoxidil.

This study investigated the effects of the herbal formulation DA-5512 on hair growth, finding that it significantly promotes dermal papilla cell proliferation and stimulates hair growth in mice while showing efficacy and safety in human trials compared to placebo and minoxidil (3%).

The study found that Sh-Polypeptide 9, a biomimetic peptide, enhances endothelial tubulogenesis and VEGF production more effectively than minoxidil, particularly at low concentrations, suggesting potential for hair follicle vascularization.

In laboratory settings, this study suggests that Serenoa repens and N-acetyl glucosamine with milk proteins may promote hair follicle vascularization through specific cellular interactions and actions.

This review discusses the hair growth mechanisms of minoxidil, suggesting both increased blood flow and a direct effect on hair follicles, but reports no new clinical results.

This study focused on developing a nanoemulsion-based gel for delivering minoxidil, aiming to enhance its contact time with the scalp and potentially improve skin absorption compared to conventional topical solutions.

This review analyzed randomized controlled trials on alopecia areata treatment and found that while several treatments showed effectiveness, most studies had limitations affecting their interpretability.

This review summarizes the application of microneedles in treating various skin diseases and highlights challenges like low drug loading, noting no new clinical results are reported.

This review examines complementary and alternative medicine for alopecia and finds limited support from robust clinical trials, highlighting the need for standardized studies to evaluate efficacy and safety.

This study found that GLI2 plays a key role in activating follistatin, an activin/BMP antagonist, in response to hedgehog signaling in human epidermal cells, with implications for hair follicle development and basal cell carcinoma.

In this study, Geranium sibiricum L. extract promoted hair growth in vitro with human dermal papilla cells and in vivo in mice, outperforming minoxidil by proliferating cells and stimulating growth factor expression, suggesting its potential as a hair growth treatment.