89 citations
,
November 2017 in “Journal of Cellular Physiology” This review discusses the role of Wnt/β‐catenin signaling in stem and cancer stem cell maintenance and its involvement in the development and regeneration of various organs, but reports no new experimental results.
88 citations
,
July 2014 in “Journal of the American Academy of Dermatology” This review discusses common cutaneous reactions to targeted cancer drugs such as tyrosine kinase inhibitors and reports no new clinical results.
80 citations
,
September 2007 in “Cell Cycle” This study found that nestin-expressing cells in the hair follicle bulge exhibit multipotent stem cell-like properties and can generate neural cells both in vitro and in vivo.
67 citations
,
May 2016 in “Journal of Cosmetic Dermatology” This study describes commonly used peptides, proteins, and growth factors in cosmeceuticals and discusses their potential benefits in dermatology, though their long-term effects remain unconfirmed.
66 citations
,
January 2017 in “Acta dermato-venereologica” This review suggests that isotretinoin's effects on severe acne and various cancers may result from apoptosis, which might also explain its adverse effects through genetic variability.
64 citations
,
March 2021 in “Anaesthesia” This review discusses the history and impact of iron deficiency anemia in women, highlighting its prevalence and the need for better detection and care, especially for those undergoing anesthesia.
63 citations
,
January 2021 in “Adipocyte” This review discusses the physiological and pathological roles of adipose tissue-derived exosomes and highlights areas for future research, without presenting new experimental findings.
59 citations
,
November 2010 in “Circulation Research” This review discusses the potential role of Wnt signaling in aging-related heart diseases and reports no clinical results.
58 citations
,
January 2013 in “The Journal of Clinical Endocrinology and Metabolism” This study suggests that sexual dimorphism in adipose tissue functions may be linked to androgen levels, as women with PCOS demonstrated a more masculine adipokine expression pattern.
56 citations
,
November 1993 in “Journal of The American Academy of Dermatology” Capsaicin cream quickly relieved itching in two patients with brachioradial pruritus.
52 citations
,
February 2006 in “Current pharmaceutical design” This review discusses the use of 5α-reductase inhibitors in treating benign prostatic hyperplasia, highlighting their long-term effectiveness and benefits when combined with α1-adrenergic antagonists; it reports no new clinical results.
46 citations
,
December 2018 in “Genes & Development” This review discusses lung regeneration and highlights the role of facultative stem/progenitor cells, but it reports no new findings and calls for further exploration of underlying mechanisms.
41 citations
,
November 2003 in “Annals of the New York Academy of Sciences” This article discusses the complexities of androgen and antiandrogen therapies in women, detailing diagnostic measures, the effects on libido, and the potential benefits of new progestins with antiandrogenic properties, but presents no new empirical findings.
40 citations
,
July 2011 in “The journal of clinical hypertension” This article reviews the use of hydralazine, minoxidil, and sodium nitroprusside in managing hypertension and hypertensive crises, noting specific indications, adverse effects, and the adjunctive therapies needed to mitigate side effects.
37 citations
,
January 2009 in “The Journal of Dermatology” In this study, hair follicle stem cells from ND-GFP transgenic mice were observed to be pluripotent, effectively repairing peripheral nerve and spinal cord injuries in mouse models.
35 citations
,
May 2021 in “Nature communications” This study found that basement membrane components and structures in mouse hair follicles are highly specialized for specific inter-tissue interactions, with laminin α5 playing a crucial role in hair cycle regulation and anchoring.
32 citations
,
January 2006 in “Liver transplantation” This case report describes a 60-year-old male with vitamin A toxicity leading to severe liver disease and symptoms that resolved following liver transplantation, suggesting transplantation as a treatment option for noncirrhotic portal hypertension when symptoms do not improve after stopping vitamin A.
31 citations
,
May 2018 in “Seminars in Plastic Surgery” This article reviews lip reconstruction techniques after Mohs surgery, presenting an algorithm to aid decision-making based on defect location and tissue involvement, and reports no new clinical results.
29 citations
,
July 2008 in “British Journal of Dermatology” This case report examines a patient with myasthenia gravis, invasive thymoma, and paraneoplastic pemphigus associated with alopecia areata, notably without the usual mucosal involvement.
29 citations
,
November 1975 in “Clinics in endocrinology and metabolism” This article discusses the synthesis and action of testosterone and its interaction with specific receptors, reporting no new research findings.
27 citations
,
September 2015 in “PharmaNutrition” This article discusses various potential health benefits and increasing global interest in astaxanthin but presents no new clinical results, though ongoing trials are exploring its effects on chronic diseases and other conditions.
26 citations
,
December 2020 in “Cleveland Clinic Journal of Medicine” This review examines the roles of androgens in women's health and provides recommendations for androgen therapy but reports no new results.
26 citations
,
March 2001 in “PubMed” This article reviews the effect of aging on male hormone levels and fertility, highlighting the need for more research on the benefits and risks of androgen supplementation in older men.
25 citations
,
April 2021 in “The EMBO Journal” This review discusses the role of hair follicle stem cells as active signaling centers in skin homeostasis, highlighting recent advancements and reporting no new clinical results.
25 citations
,
December 2009 in “Developmental Neurobiology” In this study, the authors concluded that androgens, but not estrogens, strictly mediate the maintenance of neuromuscular morphology in the spinal nucleus of the bulbocavernosus in adult rats.
25 citations
,
November 2005 in “PubMed” This study found that finasteride altered androgen receptor expression in the rat epididymis without affecting the morphology of epididymal epithelium, suggesting a change in hormonal status.
23 citations
,
August 2005 in “Expert opinion on pharmacotherapy” This review examines the benefits and potential risks of androgen replacement therapy for male hypogonadism but reports no new clinical results; the authors highlight the need for careful risk assessment, especially in older men.
22 citations
,
November 2011 in “Journal of Analytical Toxicology” This review discusses the relevance of human androgen receptor action in sports doping and examines the potential of cell-based biological assays for detecting androgenic anabolic steroid use, without presenting new research findings.
21 citations
,
January 2020 in “General and Comparative Endocrinology” This review examines the diverse roles of SRD5α enzymes across species, focusing on their involvement in steroid synthesis, sexual development, and various physiological processes, but reports no new clinical results.
21 citations
,
February 2016 in “Reproductive Biomedicine Online” This review examines how genetic variants associated with polycystic ovary syndrome affect reproductive success differently in men and women, supporting the theory that intralocus sexual conflict may explain its persistence.