71 citations,
June 2001 in “American Journal of Pathology” The p53 protein helps control hair follicle shrinking by promoting cell death in mice.
42 citations,
March 2006 in “Drug Discovery Today: Therapeutic Strategies” The conclusion is that we need more effective hair loss treatments than the current ones, and these could include new drugs, gene and stem cell therapy, hormones, and scalp cooling, but they all need thorough safety testing.
38 citations,
September 2019 in “Chinese Medical Journal” Using steroids can increase the risk of heart problems.
30 citations,
July 2017 in “BioEssays” Activating NRF2 might help treat hair disorders by improving antioxidant defenses.
30 citations,
December 2017 in “Medical Hypotheses” The model suggests that scalp tension could lead to hair loss, with factors like blood vessel hardening, enlarged oil glands, and poor microcirculation also playing a role. It also hints at a possible link between skull shape and baldness pattern.
13 citations,
January 2010 in “Advances in Biochemical Engineering / Biotechnology” Understanding hair biology is key to developing better treatments for hair and scalp issues.
2 citations,
August 2023 in “Marine drugs” Collagen from tilapia scales may improve hair and skin health by reducing stress and inflammation and encouraging hair growth.
FGF5 spliceosomes inhibit rabbit hair growth by affecting gene expression.
April 2022 in “Molecules” Teak leaf extract contains compounds that could help treat hair loss.
37 citations,
February 2013 in “Maturitas” Testosterone therapy is beneficial for women's health and does not cause masculinization or liver damage, and it protects the heart and breasts.
1 citations,
January 2022 in “Faculty reviews” The best long-lasting results in treating hair loss may be achieved through combination therapy, including treatments like finasteride, minoxidil, and platelet-rich plasma injections.
November 2014 in “John Wiley & Sons, Ltd eBooks” Eating high-glycemic and dairy foods can increase hormones that may cause acne and other health issues.
101 citations,
March 2019 in “Cell Stem Cell” Certain immune cells in the skin release a protein that stops hair growth by keeping hair stem cells inactive.
56 citations,
July 2014 in “PloS one” SARMs may be an effective treatment for a certain type of breast cancer by blocking cancer growth and spread.
9 citations,
August 2022 in “Frontiers in Pharmacology” Kangfuxin (KFX) extract speeds up wound healing and improves skin regeneration.
5 citations,
August 2021 in “Journal of biological chemistry/The Journal of biological chemistry” Retinoic acid affects male and female muscle energy use and function differently.
April 2016 in “Journal of Investigative Dermatology” Double-stranded RNA activates a pathway that causes a skin protein to be expressed in the wrong place.
64 citations,
March 2006 in “Food Chemistry” The triterpenoids from Ganoderma lucidum can block testosterone effects and may help treat enlarged prostate.
179 citations,
July 2016 in “Nature Reviews Molecular Cell Biology” Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.
70 citations,
July 2005 in “Journal of Ethnopharmacology” Ganoderma lucidum, a type of mushroom, may help treat enlarged prostate by blocking testosterone conversion.
66 citations,
January 2017 in “Acta dermato-venereologica” Isotretinoin's effects and side effects, like birth defects and depression, might be due to it causing cell death in various cells.
71 citations,
August 2019 in “The journal of sexual medicine” Testosterone treatment effectively causes male physical development in transgender male adolescents but may lead to side effects like acne, higher BMI and blood pressure, lower good cholesterol, and decreased bone density.
59 citations,
August 1998 in “International Journal of Dermatology” Genetics and hormones cause hair loss; finasteride treats it safely.
29 citations,
December 2012 in “Fibrogenesis & Tissue Repair” Adult stem cells are important for tissue repair and have therapeutic potential, but more research is needed to fully use them.
22 citations,
February 2013 in “Wound Repair and Regeneration” Mice genetically modified to produce more CD109 in their skin had less inflammation and better healing with less scarring.
11 citations,
August 2009 in “Expert Opinion on Drug Discovery” We need better ways to test and understand SARMs to make safer and more effective treatments.
176 citations,
June 2017 in “Sexual Medicine Reviews” Erectile dysfunction is increasingly common in men under 40, with many physical and psychological causes, and various treatment options available.
77 citations,
May 2012 in “Expert Opinion on Emerging Drugs” New treatments for male hypogonadism are effective and should be personalized.
22 citations,
March 2018 in “American Journal of Clinical Dermatology” New acne treatments show promise as alternatives to traditional therapies.
22 citations,
November 2011 in “Journal of Analytical Toxicology” Scientists have developed a new method to detect steroid abuse in athletes using cell-based tests, which could be the future of anti-doping methods.