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Testosterone therapy improves physical function, strength, and body composition in older men with low testosterone levels.

The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Turning white fat into brown-like fat could help fight obesity and type 2 diabetes.

Improving artificial vascular grafts requires better materials and surface designs to reduce blood clotting and support blood vessel cell growth.

Targeting colon cancer stem cells might lead to better treatment results.

Some wound-healing cells can turn into fat cells around new hair growth in mice.

Obesity affects skin health, causing conditions like acanthosis nigricans and may require different treatment approaches.

Understanding phenotypic plasticity is crucial for developing effective cancer therapies.

The guidelines suggest lifestyle changes, diet adjustments, and personalized medication to manage dyslipidemia and reduce heart disease risk.

The Rotterdam Study updated findings on elderly health, focusing on heart disease, genetics, lifestyle effects, and disease understanding.

The nanofibers with two growth factors improved wound healing by supporting structure, preventing infection, and aiding tissue growth.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Calreticulin has roles in healing, immune response, and disease beyond its known functions in the endoplasmic reticulum.

The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

Stem cell niches are crucial for regulating stem cell behavior and tissue health, and their decline can impact aging and cancer.

Changing how mesenchymal stromal cells are grown can improve their healing abilities.

Increasing mir-302 turns human hair cells into stem cells by changing gene regulation and demethylation.

The document concludes that the understanding of scar formation is incomplete and current prevention and treatment for hypertrophic scars and keloids are not fully effective.

Chemicals and body size might change when puberty starts and progresses, but more research is needed to confirm this.

The article suggests managing interferon beta therapy side effects in MS with dose adjustments, medications, and patient education.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

The NAMS 2014 recommendations guide healthcare providers on treating health issues in midlife women, emphasizing individualized care and informed decision-making.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

The document concludes that the fast-growing direct-to-consumer genetic testing market lacks sufficient regulation, posing risks to consumers due to questionable test quality and accuracy.

Melanocyte stem cells in hair follicles are key for hair color and could help treat greying and pigment disorders.

The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.

The report recommends personalized treatment for women's sexual dysfunctions and more research on effective therapies.

Blocking the enzyme 5α-reductase can shrink the prostate and help treat enlarged prostate issues.