4 citations
,
May 2014 in “Biochemical Society Transactions” This review discusses environmental reprogramming and the plasticity of epithelial cells, emphasizing their potential for new cell therapy approaches; it reports no new experimental results.
4 citations
,
January 2013 in “Advances in Experimental Medicine and Biology” This article reviews mammalian skin epidermis as a model for studying stem cell regulation, noting the utility of in vitro and ex vivo platforms, but it reports no new empirical findings.
1 citations
,
November 2023 in “iScience” In this study, researchers found that disrupting desmoglein 3 signaling in a mouse model of pemphigus vulgaris activates normally quiescent hair follicle stem cells, compromising their multipotency but prompting a regenerative response that restores stem cell function and structures.
June 2026 in “Research Square” This study identified a group of dermal fibroblasts near hair follicle stem cells in mice that facilitate hair regeneration by creating a biomechanically compliant extracellular matrix, enhancing stem cell activation and promoting a positive feedback loop for tissue regeneration.
April 2026 in “Research Square” E13 fetal mouse fibroblast vesicles may help reduce scarring.
March 2024 in “Drug development & registration” This review highlights the potential of mesenchymal stem cell secretome for developing topical treatments aimed at skin regeneration and treating various diseases, but notes a lack of studies on safety, efficacy, and standardization processes for its clinical use.
This review discusses the use of umbilical cord blood in regenerative medicine, focusing on collection, banking processes, and ethical considerations, without presenting new clinical results.
This review discusses the potential of extracellular vesicles from various sources for skin rejuvenation and cosmetic use, noting promising results, especially with mesenchymal stem cell-derived vesicles, but reports no new clinical results.
The study found that adipose-derived mesenchymal stem cells obtained via laser-assisted liposuction with selective photo-stimulation are comparable in differentiation potential and tumorigenic risk to those from conventional liposuction for cell therapy applications.
November 2019 in “Клітинна та органна трансплантологія” This review discusses the functional properties and clinical applications of adipose-derived stem cells in aesthetic medicine and dermatology, but it reports no new clinical results.
September 2013 in “Experimental Dermatology” The document concluded that stem cells are crucial for skin repair, regeneration, and may help in developing advanced skin substitutes.
April 2026 in “DiRROS repository (University of Maribor)” This review discusses the therapeutic potential and challenges of using extracellular vesicles derived from mesenchymal stem cells, concluding that they may have a comparable therapeutic potential to the original cells despite current challenges in their application and production.
143 citations
,
May 2017 in “Nature cell biology” This study found that the transcription factor Gata6 regulates the sebaceous duct lineage identity and plays a crucial role in epidermal wound healing by enabling dedifferentiation and broader lineage capabilities in post-mitotic cells.
131 citations
,
July 2009 in “Experimental Dermatology” This review discusses the development and advances in studying trichogenic dermal cells for hair follicle morphogenesis, summarizing methods, bioassays, and molecular markers, but reports no new research findings.
76 citations
,
January 2017 in “World Journal of Stem Cells” This review discusses the potential applications of adipose-derived stromal cells for treating conditions like colitis, liver failure, and more, without presenting new clinical results.
27 citations
,
September 2018 in “Nanomedicine: Nanotechnology, Biology and Medicine” This review discusses recent advances in hair regeneration therapies, highlighting the potential of nanotechnology and pluripotent stem cells, and reports no new results, emphasizing the need for further research.
9 citations
,
January 2015 in “Laboratory Animal Research” This study found that oral administration of Laminaria japonica and Cistanche tubulosa extracts may improve hair regrowth in mice, comparable to the effects of 3% Minoxidil, potentially due to their anti-inflammatory properties.
2 citations
,
April 2021 in “International Journal of Molecular Sciences” This study found that the culture conditions, not species-specific differences, determined whether sika deer dermal papilla cells adopted a 3D spheroidal or 2D monolayer growth pattern, influencing their hair-inducing ability.
January 2025 in “International Journal of Herbal Medicine” This review highlights that while dandruff affects over 50% of humans and cannot be fully eradicated, it can be controlled through chemical treatments that may cause side effects or herbal remedies such as Neem and Tea tree oil, which have longstanding use in hair care.
13 citations
,
March 2013 in “International Journal of Cosmetic Science” This study reports that the tetrapeptide AcSDKP significantly promotes skin and hair health in vitro and ex vivo, suggesting it could be used cosmetically to counteract skin aging and hair loss.
64 citations
,
August 2007 in “Artificial Organs” This study found that PHBV cocultured with epithelial and dermal cells might enhance early-stage wound healing by promoting wound closure and re-epithelization more effectively than PHBV/collagen.
18 citations
,
January 2019 in “Experimental Dermatology” This study suggests that damaged anagen hair follicles have the capability to repair themselves and resume growth by mobilizing extra-bulge epithelial cells, particularly after injuries like chemotherapy and radiotherapy.
11 citations
,
February 2019 in “Stem cells international” In this study, researchers found that while both hair follicles and skin dermis-derived neural crest stem cells are suitable for large-scale manufacturing, skin dermis cells grow faster and are easier to obtain.
3 citations
,
July 2020 in “International Journal of Molecular Sciences” This study reported that molecules from Zebrafish embryo cell differentiation can counteract neurodegeneration, regenerate tissues, and potentially reverse hair follicle damage in androgenetic alopecia.
3 citations
,
December 2016 in “Springer eBooks” This study found that activating Toll-like receptor 3 in periodontal ligament stem cells enhanced their stem cell and immunosuppressive properties, potentially supporting effective periodontal tissue regeneration.
May 2025 in “Science Advances” In this study, researchers reported that hair follicle stem cells maintain quiescence through a PIEZO1-dependent mechanism that senses mechanical forces and translates them into localized calcium influx, involving a transcriptional network that regulates cell adhesion and cytoskeleton-related genes.
41 citations
,
April 2019 in “PLOS genetics” This study found that CD34- melanocyte stem cells regenerated pigmentation more efficiently, while CD34+ cells showed potential for neuron myelination, suggesting different therapeutic applications for each population.
14 citations
,
April 2015 in “Stem Cell Research & Therapy” This study found that dermal stem cells from granulation tissue promoted wound healing and reduced fibrosis in a combined radiation and skin wound mouse model.
10 citations
,
August 2021 in “Frontiers in cell and developmental biology” This study suggests the possibility of regenerating hair follicle structures in vitro using hiPSC-derived cell composites, which might reduce reliance on human tissue-derived cells for hair bioengineering.
2 citations
,
April 2025 in “Cells” This study found that heat preconditioning of nanofat from mice did not improve tissue vascularization or integration in grafting, and actually reduced vascularization due to increased expression of anti-angiogenic factors, suggesting it is not beneficial for enhancing its vascularization properties.