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Estrogens and SERMs can help with skin aging, but their safety and effectiveness need more research.

Stress increases certain chemicals in the skin and nerves, which might worsen skin conditions.

Microneedle technology has improved drug delivery and patient comfort but needs more research for broader use.

Chemotherapy and bone marrow transplant can cause permanent hair loss.

There is no clear recommendation for using selenium in cancer patients; it may be beneficial to correct low selenium levels before treatment.

Citrullus colocynthis has pain-relieving, anti-inflammatory, antidiabetic, and hair growth benefits, but can cause side effects like colic and diarrhea.

CYP2B12 enzyme in skin cells converts arachidonic acid into specific bioactive lipids.

WNT10A helps esophageal cancer cells spread and keep renewing themselves.

Research on epidermal stem cells has advanced significantly, showing promise for improved clinical therapies.

Skin bacteria, specifically Staphylococcus aureus, help in wound healing and hair growth by using IL-1β signaling. Using antibiotics on skin wounds can slow down this natural healing process.

K16 can partially replace K14 but causes hair loss and skin issues.

Oral retinoids are effective for severe skin conditions but require careful use due to side effects.

Pregnant women often experience skin and hair changes, with over half getting stretch marks and pigment changes, and should be cautious with cosmetic procedures due to potential risks.

Finasteride increases hair density in female androgenetic alopecia, but individual results may vary.

RANK is a key target in breast cancer treatment due to its role in tumor growth and bone metastasis.

Botox increased hair count in men with baldness and might work by improving scalp blood flow.

The document concludes that more research is needed to understand how to treat muscle pain with drugs.

The protein StAR is found in 17 different organs and can affect hair loss and brain functions, but its full role is not yet fully understood.

Toxic epidermal necrolysis is a severe skin reaction often linked to drugs, requiring careful medication use and supportive care.

Improved hair loss treatment using special particles and surfactants.

Mood stabilizers can cause serious skin reactions; careful monitoring and immediate treatment are crucial.

Skin symptoms are important for diagnosing and managing juvenile-onset systemic lupus erythematosus and usually get better with treatment.

People with late-stage HIV-1 often experience a specific type of hair loss linked to multiple factors, including nutritional issues and immune responses.

Targeted cancer therapies often cause skin problems that need careful management to improve patient quality of life and treatment success.

The conclusion is that hirsutism should be diagnosed and treated because it affects quality of life and may signal other health problems.

New drug delivery methods can make natural compounds more effective and stable.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Common acne treatments can cause various side effects, like skin irritation and more serious issues, but combination therapies are often more effective and better tolerated.

Skin problems like acne, dry skin, and nail and hair changes are common in patients taking EGFR inhibitors.

Isotretinoin effectively reduces acne but causes dry skin, higher skin pH, more redness, and hair loss.