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High mTORC1 activity slows hair growth and causes it to lose color.

The mTOR pathway may be involved in the development of hair follicle tumors, with higher activity in malignant tumors.

The document concludes that DNA methylation and the mTOR pathway are important for stem cell function and could impact disease treatment.

The April 2016 JEADV issue covered various dermatology topics, including psoriasis, psoriatic arthritis, mTOR inhibitors, autoimmune diseases, photodynamic therapy, viral DNA in skin diseases, chronic hand eczema, and female hair loss.

Phosphorylation controls TFEB's location in the cell, affecting cell metabolism and stress response.

Cancer treatments targeting specific cells and the immune system can cause skin, mouth, hair, and nail problems, affecting patients' quality of life and treatment adherence.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Copper-doxorubicin nanoparticles effectively treat tumors with less toxicity.

Eating a high-glycemic diet may worsen acne by increasing certain protein levels and expressions in the skin.

The protein folliculin, involved in a rare disease, works with another protein to control how cells stick together and their organization, and changes in this interaction can lead to disease symptoms.

Glutamine metabolism affects hair stem cell maintenance and their ability to change back to stem cells.

Targeted cancer therapies often cause skin problems that need careful management to improve patient quality of life and treatment success.

New therapies for Birt–Hogg–Dubé syndrome are being developed based on understanding the FLCN gene's role.

Cells from a skin condition can create new hair follicles and similar growths in mice, and a specific treatment can reduce these effects.

Studying premature aging syndromes helps understand human aging and suggests potential treatments.

Disrupting the Flcn gene in mice causes early kidney cysts and tumors, which can be treated with rapamycin.

The document concludes that hair curvature can be explained by the growth patterns caused by the shape and separation of cells in the hair follicle and is affected by specific molecular pathways.

Rapamycin treatment helps with mitochondrial disease by reducing PKC levels.

Dihydrotestosterone (DHT) doesn't affect rat skin cell growth, but it does change cell cycle, protein levels, and other cell functions, potentially shortening hair growth cycle.

Certain cells outside the hair follicle's bulge area can quickly regenerate damaged hair follicles, potentially helping to reduce hair loss from cancer treatments.

ADM scaffolds help skin heal by promoting a healing-type immune response.

The study found that analyzing certain cell signaling pathways is not a reliable method to tell apart two types of skin tumors.

Skin problems from transplant drugs are common and need careful management in organ transplant patients.

Heat stress reduced hair growth and affected related genes in rex rabbits.

Eclipta prostrata helps hair growth and maintains the growth phase by affecting certain growth factors.

Birt–Hogg–Dubé syndrome is a rare genetic condition causing skin lesions, lung cysts, and a higher chance of kidney cancer.

Eating fewer calories may slow skin aging and improve skin health through various biological changes.

Adenine helps delay aging in human hair follicle cells.

Rapamycin may help treat Leigh syndrome by targeting protein kinase C.

Eating fewer calories improves the ability of stem cells to repair and renew the body in various tissues.