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    Glossary MT-CO1

    encodes a key enzyme subunit for cellular energy production

    MT-CO1, also known as Mitochondrially Encoded Cytochrome C Oxidase I, is a gene found in mitochondrial DNA that encodes a key subunit of the enzyme cytochrome c oxidase. This enzyme is crucial for the electron transport chain, which is a series of reactions that produce energy in the form of ATP within cells. Mutations in MT-CO1 can affect cellular energy production and are associated with various mitochondrial disorders.

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    1. 1368 Does mitochondrial dysfunction drive immune privilege collapse in lichen planopilaris pathogenesis? 2018
    2. 811 Mitochondrial MPZL3 in the inner root sheath regulates human hair follicle cycling ex vivo Journal of Investigative Dermatology · 2024 · 1 citations
    3. 1433 Epithelially derived, mitochondrial MPZL3 negatively regulates murine and human hair follicle cycling Journal of Investigative Dermatology · 2023
    4. 558 The Bacterial Metabolite, Butyrate, Prolongs Anagen and Promotes Autophagy, Mitochondrial Activity, Melanogenesis and Antimicrobial Peptide Production in Human Scalp Hair Follicles Journal of Investigative Dermatology · 2022
    5. 581 Spontaneous, Intrinsic Aging in Organ-Cultured Human Skin as Novel Ex Vivo Assay to Test Candidate Anti-Aging Actives Journal of Investigative Dermatology · 2022
    6. LB1017 A novel link between human hair follicle neuroimmunology and mitochondrial biology: Substance P increases intrafollicular oxidative stress and mitochondrial biogenesis Journal of Investigative Dermatology · 2022
    7. Cutaneous lupus erythematosus. Diagnostic and therapeutic recommendations of the Polish Dermatological Society Przegla̧d dermatologiczny · 2018
    8. Effect of 5α-Dihydrotestosterone and Testosterone on Apoptosis in Human Dermal Papilla Cells Skin Pharmacology and Physiology · 2006 · 58 citations
    9. Genome wide association analysis of root hair traits in rice reveals novel genomic regions controlling epidermal cell differentiation BMC plant biology · 2023 · 2 citations
    10. Stem Cells and the Niche: A Dynamic Duo Cell Stem Cell · 2010 · 333 citations
    11. Thyroxine (T4) may promote re-epithelialisation and angiogenesis in wounded human skin ex vivo PLoS ONE · 2019 · 27 citations
    12. 1365 Interest of Biotrinine®, a mix of Nasturtium officinale and Tropaeolum majus extracts, for chronic hair loss treatment 2018
    13. Adipose tissue-derived stromal vascular fraction in regenerative medicine: a brief review on biology and translation Stem Cell Research & Therapy · 2017 · 316 citations
    14. Ubiquity and Diversity of Human-Associated Demodex Mites PLoS ONE · 2014 · 83 citations
    15. Patient Validation of Estimation of Health Utility Values in Alopecia Areata PharmacoEconomics - Open · 2025
    16. Molecular heterogeneity of quiescent melanocyte stem cells revealed by single-cell RNA-sequencing bioRxiv (Cold Spring Harbor Laboratory) · 2023
    17. The Thyroid Hormone Analogue KB2115 (Eprotirome) Prolongs Human Hair Growth (Anagen) Ex Vivo Journal of Investigative Dermatology · 2016 · 17 citations
    18. Topical L‐thyroxine: The Cinderella among hormones waiting to dance on the floor of dermatological therapy? Experimental Dermatology · 2020 · 9 citations
    19. Research progress on mechanisms of skin aging and anti-aging strategies Aging Research · 2026
    20. Comparative overview of phytoconstituents and pharmacological potential of Trigonella foenum-graecum leaves and seeds International Journal of Ayurvedic Medicine · 2025
    21. Hypothalamic–Pituitary–Thyroid Axis Hormones Stimulate Mitochondrial Function and Biogenesis in Human Hair Follicles Journal of Investigative Dermatology · 2013 · 95 citations
    22. Skin Microbiome, Metabolome and Skin Phenome, from the Perspectives of Skin as an Ecosystem Phenomics · 2022 · 5 citations
    23. 686 Topical melatonin unfolds differential anti-aging effects in human skin by inhibiting mTORC1 activity via TSC2 stimulation Journal of Investigative Dermatology · 2024
    24. Observations that suggest a contribution of altered dermal papilla mitochondrial function to androgenetic alopecia Experimental Dermatology · 2022 · 4 citations
    25. Periplaneta americana extract (L.) promotes hair regrowth in Alopecia areata mice by reducing inflammation and modulating skin microbiota Frontiers in Pharmacology · 2025
    26. COVID-19: The question of genetic diversity and therapeutic intervention approaches Genetics and Molecular Biology · 2021 · 4 citations
    27. Human Female Hair Follicles Are a Direct, Nonclassical Target for Thyroid-Stimulating Hormone Journal of Investigative Dermatology · 2008 · 90 citations
    28. Mitochondrial Function in Murine Skin Epithelium Is Crucial for Hair Follicle Morphogenesis and Epithelial–Mesenchymal Interactions Journal of Investigative Dermatology · 2015 · 56 citations
    29. Long-Term Bezafibrate Treatment Improves Skin and Spleen Phenotypes of the mtDNA Mutator Mouse PLoS ONE · 2012 · 42 citations
    30. PPAR‐γ signalling as a key mediator of human hair follicle physiology and pathology Experimental Dermatology · 2019 · 24 citations