June 2023 in “Oriental Journal of Chemistry/Oriental journal of chemistry” This study demonstrated that derivatives of dehydroepiandrosterone (2a-b, 3a-f, and 4a-f) significantly reduced viable LNCaP prostate cancer cells, suggesting potential therapeutic use for metastatic prostate cancer, while finasteride did not alter cell viability.
March 2022 in “Journal of Clinical Case Studies Reviews & Reports” COVID-19 can cause or worsen skin conditions and might show early signs of infection.
53 citations
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June 1993 in “Proceedings of the National Academy of Sciences of the United States of America” This study identified LY191704 as a specific noncompetitive inhibitor of human 5 alpha-reductase type 1, which may be useful in treating endocrine disorders related to DHT overproduction.
6 citations
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March 2003 in “Archiv Der Pharmazie” This study reported that newly synthesized nonsteroidal compounds were effective at inhibiting prostatic 5 alpha reductase isozyme 2, especially the compound with an N, N-diisopropylcarbamoyl substituent, suggesting potential for treating benign prostatic hyperplasia.
2 citations
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October 2015 in “Human Gene Therapy” The congress highlighted new gene therapy techniques and cell transplantation methods for treating diseases.
March 2022 in “Journal of clinical case studies reviews & reports” COVID-19 can cause different skin issues, including rashes and hair loss.
26 citations
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March 2014 in “International journal of pharmaceutics” This study confirmed that the novel solid lipid microparticle formulation of adapalene demonstrated follicular penetration potential and targeted particle erosion in sebum in in vitro tests.
22 citations
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August 2011 in “Journal of Supercritical Fluids” In this study, fraction No. 3 of Oryza sativa bran extract demonstrated high unsaturated fatty acid content and significant 5α-reductase inhibition, suggesting potential for developing anti-androgenic alopecia products.
14 citations
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July 2021 in “Biomedicines” This review discusses the roles of platelets in hemostasis and wound repair, the preparation methods for platelet concentrates, and their therapeutic applications in medicine and dentistry, reporting no new clinical results.
9 citations
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February 2022 in “Archives animal breeding/Archiv für Tierzucht” This study found that circRNA-0100 promotes differentiation of secondary hair follicle stem cells into hair lineage in cashmere goats by sequestering miR-153-3p, which enhances KLF5 expression.
24 citations
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February 2022 in “Reviews in Endocrine and Metabolic Disorders” This review reports that women with polycystic ovary syndrome are at 28%–50% higher risk of SARS-CoV-2 infection, with increased rates of COVID-19-related hospitalization, morbidity, and mortality.
32 citations
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July 2012 in “Stem Cells Translational Medicine” In this study, VD(3) pretreatment increased hair follicle formation in a rat model by promoting dermal papilla cell differentiation, suggesting potential for hair regeneration therapy.
26 citations
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February 2009 in “Drug Development Research” This article reviews the potential neuroprotective effects of 17α‐estradiol in neurodegenerative diseases and highlights its possibly lower toxicity compared to more feminizing hormones, but it reports no new clinical findings.
16 citations
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November 2020 in “Research Square (Research Square)” In this study, early treatment with nitazoxanide, ivermectin, or hydroxychloroquine, combined with azithromycin, was associated with reduced hospitalizations, respiratory complications, and deaths in early-stage COVID-19 patients compared to untreated controls.
11 citations
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November 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study observed that early treatment with azithromycin and either nitazoxanide, ivermectin, or hydroxychloroquine in COVID-19 patients may reduce viral shedding, symptom duration, and respiratory complications compared to untreated patients.
7 citations
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January 2019 in “Australasian Journal of Dermatology” In this study, the CYP 21A2 gene p.V281L mutation was associated with an increased susceptibility to familial frontal fibrosing alopecia, suggesting an antigen-driven mechanism linked to certain human leukocyte antigen haplotypes.
4 citations
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January 2019 in “Annals of Dermatology” Higher levels of MiR-92a-1-5p and miR-328-3p found in female hair loss patients.
January 2026 in “Frontiers in Medicine” This study suggests that coexisting LSS and TSPEAR variants might contribute to a complex phenotype of congenital hypotrichosis and ectodermal abnormalities in a child, and highlights the need for cautious interpretation of genotype-phenotype links and the potential value of broader genetic testing.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that miR-486 may protect against alopecia areata by maintaining hair follicle immune privilege and modulating expression of immune-related genes.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” In a laboratory setting, this study found that Biotrinine® dry extract activated hair follicle growth pathways and increased certain growth factor secretions in human dermal papilla cells, suggesting potential benefits for treating chronic hair loss.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” This study observed that Ginseng and Albizia extracts, when used together, protected human dermal papilla cells from oxidative stress-induced senescence, and inhibited genes that suppress hair growth, indicating their potential in preventing age-related hair density reduction.
Surgeons should evaluate new technologies critically, offer a range of services including non-surgical options, and be aware of marketing influences to meet patient needs and maintain a successful practice.
April 2010 in “The Journal of Urology” Human prostate cells produce more WISP1/CCN4 when there's not enough oxygen.
April 2008 in “Medical & surgical dermatology” Certain hairstyles can cause scalp diseases, smoking is linked to hair loss, 5% minoxidil foam is effective for hair loss treatment, and various factors influence wound healing and hair growth.
February 1990 in “Journal of The American Academy of Dermatology” This review summarizes therapeutic advances reported in English-language literature from December 1987 to December 1988 and states no new clinical results.
70 citations
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December 2004 in “Differentiation” This study identifies six novel keratin genes from the chromosome 17q21.2 region, suggesting their association with hair follicles, while all 27 keratin genes in the domain have been characterized transcriptionally.
April 2024 in “Research Square (Research Square)” This study found that bioconjugating 16-methylheptadecanoic acid (16-MHA) to damaged hair can mimic the protective properties of 18-methyleicosanoic acid (18-MEA), restoring the hair's structural integrity and moisture homeostasis, even after washing.
June 2022 in “Organic communications” This study explores potential treatments for post COVID-19 complications using natural substances through molecular docking, but reports no new clinical results and existing treatments remain limited to prophylaxis and therapeutics.
2 citations
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January 2026 in “Frontiers in Endocrinology” This review discusses the impaired functionality of regulatory T cells in the pancreas during the development of Type 1 diabetes, highlighting their role in disease pathogenesis, potential of Treg-based therapies, and challenges in clinical applications.
373 citations
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September 2009 in “Obstetrics & Gynecology” This review examines the best available evidence for diagnosing and managing PCOS but reports no new clinical results.