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The April 2016 JEADV issue covered various dermatology topics, including psoriasis, psoriatic arthritis, mTOR inhibitors, autoimmune diseases, photodynamic therapy, viral DNA in skin diseases, chronic hand eczema, and female hair loss.

Apoptosis, not oxidative stress, is linked to aging in mice with mtDNA mutations.

Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.

Phosphorylation controls TFEB's location in the cell, affecting cell metabolism and stress response.

Melatonin in the skin helps protect against damage from stress and UV rays, and could be used to treat certain skin conditions.

Cancer treatments targeting specific cells and the immune system can cause skin, mouth, hair, and nail problems, affecting patients' quality of life and treatment adherence.

Memory regulatory T cells need IL-7, not IL-2, to stay in peripheral tissues.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Some HIV treatments can harm mitochondria, potentially causing side effects like lactic acidosis and nerve damage.

Early detection and intensive treatment of diseases caused by Staphylococcus aureus toxins are crucial for reducing severe health effects.

Hair follicles produce and respond to melatonin, affecting hair growth and sensitivity to estrogen.

Melatonin helps regulate hair growth and protects the hair follicle from stress.

Copper-doxorubicin nanoparticles effectively treat tumors with less toxicity.

Eating a high-glycemic diet may worsen acne by increasing certain protein levels and expressions in the skin.

Drugs penetrate scalp skin better than abdominal skin, with scalp hair follicles aiding in higher drug delivery.

Methotrexate reduced the need for steroids in asthma patients without worsening their condition.

Restoring mitochondrial function in mice reversed their skin wrinkling and hair loss.

The protein folliculin, involved in a rare disease, works with another protein to control how cells stick together and their organization, and changes in this interaction can lead to disease symptoms.

Methotrexate sometimes helps regrow hair in children with severe alopecia areata and is generally safe.

Minoxidil use increases facial hair growth in females, more in older users.

Epidermal stem cells could lead to new treatments for skin and hair disorders.

Ablative fractional resurfacing could improve how well topical drugs penetrate the skin, but more research is needed to fine-tune the method.

Glutamine metabolism affects hair stem cell maintenance and their ability to change back to stem cells.

Methotrexate is a promising and safe treatment for severe alopecia areata, with better results when combined with corticosteroids.

Damaging mitochondrial DNA in mice speeds up aging due to increased reactive oxygen species, not through the p53/p21 pathway.

Targeted cancer therapies often cause skin problems that need careful management to improve patient quality of life and treatment success.

New therapies for Birt–Hogg–Dubé syndrome are being developed based on understanding the FLCN gene's role.

The research found genetic differences in identical twins that could explain why one twin has a disease while the other does not.

Cells from a skin condition can create new hair follicles and similar growths in mice, and a specific treatment can reduce these effects.

Tissue-specific variation in mutant load complicates genetic counseling and prenatal diagnosis.