June 2025 in “Medical academic journal” The study found that hybrid nanoparticles incorporating exosomes with cationic liposomes 2X3-DOPE significantly improved the delivery of both messenger RNA and small interfering RNA to rat cardiac mesenchymal stem cells in vitro, achieving up to 100% transfection efficiency for small interfering RNA.
18 citations
,
March 2015 in “Journal of Endocrinological Investigation” This study found that ZP4 expression was highest among PCOS patients with regular menstrual cycles, which may be linked to mature follicle presence, but no correlation with clinical indices was observed.
6 citations
,
January 2020 in “International journal of biological sciences” In this study, deletion of ROBO4 in mice ameliorated hair loss caused by elevated PAF levels, suggesting potential interplay with VLDLR-related pathways.
40 citations
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April 2008 in “European journal of endocrinology” In this study, treatment with insulin sensitizers significantly increased adipose tissue GLUT4 mRNA expression and improved insulin resistance, menstrual patterns, and androgen profiles in PCOS patients, with rosiglitazone being more effective than metformin.
February 2024 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that certain tandem repeats predict darker hair color across diverse ancestry groups and can contribute to a polygenic score for hair color, independent of SNP variation.
April 2018 in “bioRxiv (Cold Spring Harbor Laboratory)” This study identified a specific genetic variant in the CCHCR1 gene that may contribute to alopecia areata through impaired keratinization, suggesting an alternative mechanism beyond autoimmune causes.
35 citations
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May 2019 in “Frontiers in genetics” This study reported that specific non-coding RNAs may regulate the hair follicle cycle in Angora rabbits by acting as competitive endogenous RNAs, enhancing understanding of ncRNA roles in hair growth.
36 citations
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January 2021 in “Scientific Reports” This study identified key genes and signaling pathways involved in the growth phases of Pashmina goat hair follicles, highlighting the role of several gene families and transcription factors in fiber quality and growth regulation.
3 citations
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July 2011 in “Folia Histochemica et Cytobiologica” This study concluded that the inner root sheath inhibits the expression of certain differentiation markers in hair bulbs, with calcium-induced changes paralleling those seen in hair follicle mid-segments.
9 citations
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February 2022 in “Archives animal breeding/Archiv für Tierzucht” This study found that circRNA-0100 promotes differentiation of secondary hair follicle stem cells into hair lineage in cashmere goats by sequestering miR-153-3p, which enhances KLF5 expression.
7 citations
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January 2021 in “Evidence-based complementary and alternative medicine” This study suggests that porphyra-334 may have antiaging properties, promoting collagen synthesis, improving periorbital wrinkles, and supporting hair follicle growth through gene regulation.
1 citations
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October 2024 in “Journal of Clinical Immunology” This study observed that adult Netherton syndrome patients showed a range of normal to diminished immune responses to polysaccharide, conjugate, and mRNA-based vaccines, with responses generally overlapping those of healthy controls, suggesting no consistent B- or T-cell immunodeficiency in this population.
4 citations
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April 2021 in “Frontiers in Immunology” This study found that clusters of mRNAs and lncRNAs in the peripheral blood of PCOS patients were aberrantly expressed, and certain lncRNA-mRNA pairs in the chemokine signaling pathway may be genetically related to PCOS.
17 citations
,
May 2018 in “BMC genomics” This study found that miR-432 inhibits KRT83 expression, revealing potential molecular mechanisms for the formation of curly fleece in Tan sheep and suggesting implications for understanding curly hair formation in humans.
5 citations
,
October 2022 in “BMC genomics” In this study, researchers identified key miRNAs and target genes involved in hair follicle development in Merino sheep, providing insights that could aid in improving sheep breeding for wool quality.
62 citations
,
January 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified 16 novel high sulfur KAP genes and two KAP pseudogenes on chromosome 21q23, showing expression in a specific region of the hair fiber cuticle.
8 citations
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July 2023 in “Inflammation and Regeneration” This study found that ALKBH5 plays a critical role in wound re-epithelialization by enhancing the stability of PELI2 mRNA, and its absence delays wound healing. Supplementation with PELI2 can partially rescue this delay, pointing to potential new therapies for stubborn wounds.
4 citations
,
July 2022 in “The Journal of Clinical Endocrinology & Metabolism” This study identified a novel homozygous mutation in the 5'-UTR of the POMC gene, suggesting a new molecular mechanism for the syndrome of adrenal insufficiency, obesity, and red hair.
52 citations
,
October 1995 in “Experimental Cell Research” Human hair keratin genes hHa2 and hHb1 are located on chromosomes 17 and 12.
36 citations
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January 2018 in “Scientific reports” This study observed that dietary intake of glucoraphanin during juvenile and adolescent stages prevented cognitive deficits and abnormal gene expressions in the brain of adult offspring exposed to maternal immune activation, potentially implicating centrosome-related genes in the development of psychosis.
32 citations
,
December 2009 in “Archives of Dermatological Research” In this study, DHT was associated with increased production of proinflammatory cytokines IL-6 and TNF-α in cultured sebocytes, suggesting a role in acne pathophysiology beyond sebum production.
27 citations
,
April 1992 in “Biochemical Journal” Minoxidil reduces lysine hydroxylase in skin cells.
14 citations
,
July 2010 in “Experimental Dermatology” A new mutation in the HR gene causes hair loss in a specific family.
13 citations
,
June 2024 in “BMC Genomics” This study found distinct expression patterns of various transcription types during hair follicle morphogenesis, providing a foundation for understanding hair development mechanisms and aiding selective breeding for desirable wool traits in a specific breed.
12 citations
,
January 1991 in “Archives of dermatological research” Male hormones control a specific gene in hamster skin, with different hormones having varying effects.
9 citations
,
February 2023 in “Genes” This study reveals that long non-coding RNAs influence cashmere fiber traits in goats by interacting with target genes involved in pathways affecting fiber diameter and color.
9 citations
,
February 2022 in “BMC Genomics” This study examined gene expression in cashmere goats and identified key pathways and molecular regulators that influence hair follicle growth stages and melatonin's role in promoting cashmere growth.
2 citations
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April 2017 in “Journal of Investigative Dermatology” In this study, tofacitinib treatment led to significant hair regrowth in 60% of patients with moderate-to-severe alopecia areata, suggesting potential for JAK inhibitors in treating this condition.
2 citations
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September 2016 in “Journal of Dermatological Science” Reduced TRPS1 leads to increased STAT3 and SOX9 in hair follicles, affecting hair growth.
April 2026 in “BMC Genomics” This study identified key molecular differences between Long and Short hair type cashmere goats, suggesting hair type differentiation is linked to structural assembly and follicle remodeling.