Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study reported that ELL is crucial for maintaining the proliferative capacity of the basal layer in human epidermal keratinocytes by stabilizing RNA polymerase II at the transcription start site.

PGD2 stops hair growth and is higher in bald men with AGA.

This study reports that miR-302 promotes pluripotency by inhibiting NR2F2 and indirectly regulating OCT4 in stem cells, enhancing reprogramming efficiency when added to traditional factors.

In this study, researchers found that in late pregnancy, the neuroactive progesterone metabolite allopregnanolone inhibits HPA axis responses to immune challenges via an opioid-mediated mechanism.

In this study, researchers found that TCDD exposure accelerated differentiation and altered gene expression in human epidermal cells, indicating the epidermal barrier as a target of TCDD-activated AHR.

The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.

This study reports that GLP-1 receptors and proglucagon are expressed in the skin of newborn mice, with GLP-1 potentially playing a role in skin development and hair follicle formation.

This study demonstrated that keratin derived from human hair can improve axon extension and alleviate motor deficits from sciatic nerve injuries, highlighting its potential as a promising biomaterial for peripheral nerve regeneration.

This study found that long non-coding RNAs are differentially expressed in androgenetic alopecia, suggesting potential roles in its development and novel targets for prevention and treatment.

In this study, researchers found significant links between specific metabolic reprogramming-related genes and alopecia areata risk, highlighting increased SQSTM1 expression in affected hair follicles compared to healthy ones.

This study developed a new human in vitro hair model that replicates in vivo hair characteristics and may be suitable for high throughput screening of hair growth treatments.

In this study, researchers developed a biodegradable microneedle made of hyaluronic acid, intended to enhance drug delivery through the skin's stratum corneum and potentially promote hair growth by overcoming the skin's barrier function in alopecia treatment.

This study found that VE-cadherin and Alk1, traditionally linked to vascular functions, also play crucial roles in maintaining nerve homeostasis in mice during hair growth cycles by modulating certain cell populations.

This study found that topical finasteride and flutamide both significantly reduced sebaceous gland growth and decreased prostatic weights in hamsters, indicating systemic effects despite local application.

This review outlines drug repurposing as an efficient, low-cost strategy to identify new uses for existing drugs, highlighting various computational and experimental approaches as well as publicly available databases to aid in personalized pharmacotherapy.

This study discovered nine human type I hair keratin genes, including a transcribed pseudogene, in a 190 kbp genomic region, revealing three gene subclusters based on sequence homologies.

This study suggests that the rs2075876 variant in the AIRE gene may significantly increase susceptibility to alopecia areata in the examined male population.

This study found that two microRNAs, oar-miR-23b and oar-miR-133, inhibit the development of hair follicles in superfine wool sheep by targeting genes involved in key signaling pathways, suggesting their potential use as molecular markers for breeding fine wool sheep.

Proteins like aPKC and PDGF-AA, substances like adenosine and ATP, and adipose-derived stem cells all play important roles in hair growth and health, and could potentially be used to treat hair loss and skin conditions.

This review discusses the potential regulation of signal transduction pathways by microRNAs in animal cells, aiming to identify biological processes that may be influenced by miRNA-mediated regulation, but it reports no new experimental outcomes.

This study found that abolishing H3K27me3 in mouse skin by targeting Ezh2 and Ezh1 affects hair follicle development and epidermal behavior, revealing functional differences between these tissues.

This study found that induced expression of mir-302 can reprogram human hair follicle cells into induced pluripotent stem cells through a novel epigenetic mechanism involving global demethylation.

This review explores how adipose-derived stem cells contribute to skin homeostasis and highlights recent advances in their clinical applications in dermatology, but it reports no new clinical results.

This study found several microRNA-related genetic variants linked to epithelial ovarian cancer risk, with a notable association at the 17q21.31 region, suggesting potential new susceptibility genes.

This study found that CRISPR/Cas9-mediated disruption of the FGF5 gene in goats increased hair follicle numbers and fiber length, suggesting more cashmere production could be achieved.

This study found that SARS-CoV-2 hijacks the host factor IGF2BP1 to stabilize its RNA and enhance translation, and identified Cepharanthine and Trifluoperazine as potential treatments against the virus.

This article discusses the role of human hair follicles in neuroendocrinology and suggests potential new therapeutic targets by examining how neuromediators influence hair growth, pigmentation, and stem cell biology in organ cultures.

This study found that mice with a mutant CDP/Cux protein lacking the homeodomain showed severely impaired growth, high postnatal mortality, and reduced fertility, highlighting CDP/Cux's role in developmental regulation.

This study found that the enzyme A20 helps regulate EDAR-induced NF-κB signaling in mice, preventing ectodermal abnormalities like disheveled hair and assuring proper skin and appendage development.

In this study, researchers reported that a keratinocyte growth factor-Ig fusion protein could specifically detect and localize KGFRs in epithelial tissues, suggesting a method for histochemical detection of growth factor receptors.